2018
DOI: 10.1016/j.seizure.2018.07.011
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Evaluation of long-term antiepileptic drug use in patients with temporal lobe epilepsy: Assessment of risk factors for drug resistance and polypharmacy

Abstract: A poor effect from initial pharmacotherapy is the only early risk factor for drug resistance found in this study. Long disease duration increases the risk of drug resistance and polypharmacy. Second-generation antiepileptic drugs provide no additional effect for poor responders to first-generation drugs.

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Cited by 21 publications
(10 citation statements)
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“…The AUC of predictive model is as high as 0.96, which suggests that this model is promising to be applicable in clinical practice. In the previous research, some seizure-related characteristics, including the prior number of seizures and disease course, were reported to be related with the risk of drug resistance 4,9. Another factor strongly linked to the increased risk of intractable epilepsy is HS, which is consistent with the findings in our study.…”
supporting
confidence: 92%
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“…The AUC of predictive model is as high as 0.96, which suggests that this model is promising to be applicable in clinical practice. In the previous research, some seizure-related characteristics, including the prior number of seizures and disease course, were reported to be related with the risk of drug resistance 4,9. Another factor strongly linked to the increased risk of intractable epilepsy is HS, which is consistent with the findings in our study.…”
supporting
confidence: 92%
“…2,3 Moreover, cognitive impairment and psychiatric comorbidities including depression and anxiety disorders, together with the longterm actual seizures and accompanying drug usage, often result in severe effects on the quality of life and individual health. 4,5 At present, the diagnosis of epilepsy mainly depends on clinical manifestation, neuroimaging, and electroencephalogram (EEG).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…There are many theories and hypotheses about the causes of drug resistance in TLE (9) . There have also been many studies to predict whether TLE can evolve into drug resistance through the effect of initial drug treatment (10) and seizure frequency (11) . Furthermore, several studies have speculated about the possible mechanism of drug resistance in TLE by detecting levels of some target proteins, genes, and molecules (12)(13)(14).…”
Section: The Interictal Discharge Neural Network Of Refractory Tle Mamentioning
confidence: 99%
“…As the duration of the disease increases, there is a risk of drug resistance and polypharmacy. Worse, second-generation antiepileptic drugs provide no additional effect for poor responders to first-generation drugs [117]. Studies have proposed using randomness in such cases to partially overcome tolerance to therapies and to improve the efficacy of therapies [118120].…”
Section: Introductionmentioning
confidence: 99%