Evaluation of Loratadine Liposomal Gels for Transdermal Treatment

Abstract

Loratadine is a medication that is indicated for treating allergies. It is taken through the mouth. Side effects include dry mouth, drowsiness, and headache. Liposomes are an advanced formulation to deliver the loratadine and enhance its effectiveness to the target site through the skin while minimizing side effects. Loratadine liposomes were prepared from cholesterol, and lecithin, which are the main components in building liposomes. Different concentrations of both cholesterol and tween 80 have been used. The slow release of loratadine outside the body of the in vitro was studied in the neutral medium within the physiological range (pH = 7.2) and using the ultraviolet spectra at a constant temperature (37 ° C). The effects of cholesterol and Tween 80 concentrations in the form of particles and the release of the drug outside the Vivo were studied. It was observed that increasing the concentration of them results in a decrease in the release of the drug. Chitosan was employed as a gel base and three different gel formulations, including loratadine, loratadine liposomal gel (L3G), loratadine liposomal gel with tween 80 (LT3G), and blank chitosan gel plus loratadine (G) were prepared. The results of the cytotoxicity test showed that the studied models were non-toxic.