Evaluation of low dose ionizing radiation effect on some blood components in animal model

El-Shanshoury, H.; El-Shanshoury, G.; Abaza, A.

doi:10.1016/j.jrras.2016.01.001

Cited by 53 publications

(35 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Limited data are available about effects of varying in dose-rates and accumulated dose (Fritz, 2002). Sanzari et all suggests that a significant decline in blood cell counts after ionizing radiation depends on dose (Sanzari, Cengel, Wan, Rusek, & Kennedy, 2014) which is similar to findings in some studies that examined animals model after whole-body irradiation (El-Shanshoury, El-Shanshoury, & Abaza, 2016;Sanzari et al, 2013) or have been observed in human (Fliedner et al, 2012;Rozgaj et al, 1999). But disagreement of our results could be explained by the amount of radiation doses of participants which was too low to cause a statistically significant difference in examined parameters between two years.…”

Section: Discussionsupporting

confidence: 84%

“…Besides, some investigators have reported that, there is temporary hematopoietic recovery in healthy individuals after ionizing radiation exposures (Lushbaugh, Eisele, Burr Jr, Hubner, & Wachholz, 1990;Müller & Streffer, 1991). As shown by El-Shanshoury et al (El-Shanshoury et al, 2016) and some others studying on animal models, the blood cells recover within several days and weeks after low dose radiation exposure. Moreover as shown by Seed et al, hematopoietic repair was increased in canines under variable levels of chronic radiation (Seed, 1996).…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Hematological Findings in Medical Professionals Involved at Intraoperative Fluoroscopy

Shafiee¹,

Hoseinnezhad²,

Vafapour³

et al. 2016

GJHS

View full text Add to dashboard Cite

Medical professionals involved at intraoperative fluoroscopy are exposed to low doses of the occupational radiation exposures. The biological effects of chronic low-dose radiation on human health are complex and have not been well established. The aim of the present study is to follow up hematological parameter changes during 2 years in medical professionals exposed to ionization radiation in operating rooms.22 medical professionals (medical specialists and technicians), chronically exposed to ionizing radiation of mobile C-Arm X ray machine, were selected. The seven hematological parameters were examined each time. The statistical analyses were done by Student’s t test and one way ONOVA test.The data analysis led to the following observations: (1) the present study incorporated that the basic hematological parameters including the mean value of red blood cells (P=0.90), white blood cells (P=0.68), and platelets count (P=0.45) did not show a significant difference between two years. (2) The mean values corpuscular hemoglobin concentration, corpuscular hemoglobin, and hematocrit parameters were found disturbed low or high in some of medical professionals but their means were not significantly different between two measurements. (3)A statistically significant relation in mean value of RBCs with the duration of exposure and sex were observed.It seems that, hematological parameters survey could not be a reliable test as the biological indicator of long term exposure to very low dose of radiation exposure in medical professionals which their physical dosimetry values are lower than dose limits.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 97%

Hematological Findings in Medical Professionals Involved at Intraoperative Fluoroscopy

Shafiee¹,

Hoseinnezhad²,

Vafapour³

et al. 2016

GJHS

View full text Add to dashboard Cite

show abstract

“…Many studies have been done to find and analyze the evaluation of high and low dose ionizing radiation on hematological parameters. For instance, [2] analyze the blood variations resulting from both irradiation and time for animal rats. They found a significant reduction in WBC, platelet and RBC counts one day after irradiation increases with increasing the dose started from 0.3 to 1Gy [3] found the low dose rate on rat and dog effect the hemopoietic failure according to both total absorbed dose and on the dose-rate of multi exposures.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Low Dose Ionizing Radiation (X-ray) on Human Blood Components during Catheterization Process

Abdullah¹

2019

MACIJ

View full text Add to dashboard Cite

In a time being, ionizing radiation specifically X-ray is widely used in medicine for diagnosis and therapy. At the same time, such beneficial uses may cause potential hazardous situations for patient and the workers within the Cardiac catheterization laboratory. The present work was conducted to evaluate the changes in some components of blood cells after exposure to radiation during the Cardiac catheterization. A statistical comparative study was performed between pre (as control group) and in the early post-irradiation period of blood components on 33 patients. The mean of RBC counts, in post-irradiation are significantly lower than pre-irradiation values at 4.47±0.55 x10¹²/L and 4.84±0.59 x10¹²/L respectively, for plasma hemoglobin Hb, 11.95±1.55 g/dl and 12.71±1,62 g/dl respectively and for WBC are 6.87±1.581 and 7.58±1.577 respectively. There are no significant changes observed between pre and post-irradiated levels in RDW and MCV sizes. Even though the quantitative results of the mean percent-hemolysis level is still within the recommended acceptable levels for clinical significance. Further works are required to search other possible effects.

show abstract

“…A decrease in total white blood cell count; lymphocytes, monocytes, neutrophils, eosinophil was observed; however, basophils were not seen. This probably could be because basophils naturally are rarely encountered granulocytes in the peripheral blood, therefore, it is not unusual for basophils to be absent [29]. Previous studies have reported similar findings [6,17,30].…”

Section: Discussionmentioning

confidence: 59%

Effect of Low Dose (Diagnostic X-Rays) on Peripheral White Blood Cells Count in Guinea Pigs (Cavia porcellus)

Luntsi¹,

Daniel²,

Nwobi³

et al. 2019

Nuclear Medicine Physics

View full text Add to dashboard Cite

Exposure to ionizing radiation is known to affect some hematological parameters of biological sample. This study was aimed at evaluating the effect of ionizing radiation within the diagnostic range on some hematological parameters in guinea pigs. Thirty six (36) apparently healthy adult guinea pigs of both sexes weighing between 700 and 1200 g were used. The guinea pigs were categorized in to three groups, 12 per group; group A (control), group B, and C were exposed to X-rays within the diagnostic range, using 70 kV and 12.5mAs; using X-ray machine MS-185, serial no. 0904 GE at a source to skin distance (SSD) of 90 cm. Blood samples were collected from all the guinea pigs at intervals of 1, 24, 72, 168 and 336 hours post-irradiation, and subjected to standard hematological analysis. A continuous decline in the mean total white blood cell count and mean lymphocyte, monocyte, neutrophil and eosinophil count after 1 hour in both groups was observed, and more pronounced after 24 hours post-irradiation. However, stability was observed 72 hours post-irradiation in both groups. In conclusion, a depleting effect of low dose ionizing radiation on white blood cell count was found, with appreciable recovery occurring after 72 hours onward.

show abstract

Evaluation of low dose ionizing radiation effect on some blood components in animal model

Abstract: risk during exposure to irradiation. Much effort must be done and focused on establishment of protocols for medical management of radiation injuries based on hematopoietic changes for biodosimetry.

Cited by 53 publications

References 21 publications

Hematological Findings in Medical Professionals Involved at Intraoperative Fluoroscopy

Hematological Findings in Medical Professionals Involved at Intraoperative Fluoroscopy

Effects of the Low Dose Ionizing Radiation (X-ray) on Human Blood Components during Catheterization Process

Effect of Low Dose (Diagnostic X-Rays) on Peripheral White Blood Cells Count in Guinea Pigs (Cavia porcellus)

Contact Info

Product

Resources

About