Evaluation of macular and peripapillary choroidal thickness, macular volume and retinal nerve fiber layer in acromegaly patients

Yazgan, Serpil; Arpacı, Dilek; Çelik, Hacı Uğur; Işik, İrem

doi:10.1007/s10792-017-0500-z

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…In ocular tissues, growth in extraocular muscles [3], increase in intraocular pressure (IOP) [4], and increase in corneal thickness [5] have been shown previously. Also retinal thickness increase [6], increase in choroidal thickness [7], ganglion cell complex (GCC) thickness reduction [8][9][10][11][12], retinal nerve fibre layer (RNFL) thickness increase [6]/ decrease [4,12], and increase in the incidence of proliferative retinopathy [13] have been shown previously by using optic coherence tomography (OCT) and fundus fluorescein angiography.…”

Section: Introductionmentioning

confidence: 80%

Evaluation of the retinal layers and microvasculature in patients with acromegaly: a case-control OCT angiography study

Akay

Akmaz

Işık

et al. 2020

Eye

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Background The aim of study was to evaluate the retinal layers and macular capillary network with OCTA in acromegaly patients, to compare with healthy population. Methods In this prospective, observational, and comparative study, 40 acromegaly patients and 40 healthy control participants were included. Serum IGF-1 levels and disease duration of all patients were noted. Macular layers and angiography scanning was performed with a Zeiss Cirrus 5000 OCTA system. Macular thickness, RNFL, and GC-IPL values were obtained. For central vessel and perfusion density, central 6 mm was obtained and was evaluated by dividing into three groups (inner, outer, full). FAZ parameters were evaluated dividing into three groups (area, perimeter, circularity index). Analysis of the data was performed with the SPSS for Windows. Results There was no significant difference between the patient group and the control group in terms of age, gender, best corrected visual acuity (BCVA), spherical equivalent (SE), intraocular pressure (IOP), and axial length (AL). The mean follow-up period after diagnosis was 11.0 ± 5.5 years. Central and mean macular thicknesses were also significantly higher in the acromegaly group (p < 0.05). Superior, inferior, and average RNFL thicknesses were also significantly thinner in the acromegaly group (p < 0.05). When OCTA parameters were compared between groups, there was a significant decrease in central vessel density (CVD) and central perfusion density (CPD) values in all regions in acromegaly group compared with controls (p < 0.05). Conclusion Our findings with OCTA show that acromegaly causes a significant capillary network decrease according to the healthy subjects.

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Section: Introductionmentioning

confidence: 80%

Evaluation of the retinal layers and microvasculature in patients with acromegaly: a case-control OCT angiography study

Akay

Akmaz

Işık

et al. 2020

Eye

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“… 24 On the other hand, subfoveal choroidal thickness and foveal thickness were increased in patients with controlled acromegaly. 49 Moreover, Yazgan et el 37 showed positive correlation between macular choroidal thickness and serum IGF1 level. In turn, Polat et al 50 revealed no significant difference in mean central retinal thickness between the patients with acromegaly and the control group.…”

Section: Discussionmentioning

confidence: 96%

“…Previous reports also disclosed that there is a correlation between systemic level of IGFs and the changes in eye structures. 36 , 37 The abovementioned studies suggested that the source of elevated level of IGF family in ocular diseases still needs explanation. Moreover, there was revealed a significant correlation between serum and vitreous level of VEGF in proliferative diabetic retinopathy patients.…”

Section: Discussionmentioning

confidence: 99%

Gene expression levels of the insulin-like growth factor family in patients with AMD before and after ranibizumab intravitreal injections

Strzałka‐Mrozik

Kimsa-Furdzik

Kabiesz

et al. 2017

CIA

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PurposeThe present study focused on the assessment of the mRNA levels of the insulin-like growth factor (IGF) family in patients with the exudative form of age-related macular degeneration (AMD) before and after ranibizumab intravitreal injections.Patients and methodsAn analysis of the expression profile of the IGF family of genes in patients with AMD was carried out using the oligonucleotide microarray and quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) methods.ResultsIn the peripheral blood mononuclear cells (PBMCs) obtained from AMD group receiving ranibizumab compared to the peripheral blood mononuclear cells from AMD group before ranibizumab treatment using oligonucleotide microarray technique, six statistically significant differentially expressed transcripts related to the IGF family were detected (unpaired t-test, p<0.05, fold change >1.5). Moreover, analysis using the real-time RT-qPCR technique revealed statistically significant differences in the IGF2 and IGF2R mRNA levels (Mann–Whitney U test, p<0.05) between the two groups that were studied. Statistical analyses of both oligonucleotide microarray and real-time RT-qPCR results demonstrated a significant decreased expression only for IGF2 mRNA.ConclusionOur results revealed a changed expression of IGF2 mRNA after ranibizumab treatment.

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“…However, the subfoveal and peripapillary CT did not differ significantly between shunted patients and healthy controls. Yazgan et al ( 103 ) reported that patients with acromegaly had significantly higher macular and peripapillary CT than healthy controls. Garcia-Martin et al ( 104 ) reported that the peripapillary choroid was significantly thicker in patients with Parkinson's disease than in age- and sex-matched controls.…”

Section: Choroidal Thickness Measurement Beyond the Maculamentioning

confidence: 99%

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

Kim

2021

Front. Med.

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Enhanced depth imaging optical coherence tomography (EDI-OCT) and swept-source OCT (SS-OCT) have emerged as essential diagnostic tools in the study and management of various chorioretinal diseases. Evidence from early clinical studies using EDI-OCT and SS-OCT indicates that choroidal dysfunction plays a major role in the pathogenesis of chorioretinal diseases. Measurement of choroidal thickness (CT) has already become a major research and clinical method, and CT is considered as an indicator of choroidal status in a variety of ophthalmic diseases. Recently, CT measurement has also been proposed as a non-invasive marker for the early detection and monitoring of various systemic diseases. Among the several possible CT measurement locations, subfoveal CT has rapidly become a reliable parameter for measuring CT in healthy and diseased eyes. Moreover, recent advancements in OCT technology have enabled faster and wider imaging of the posterior part of the eye, allowing the various changes in CT as measured outside the macula to be shown accordingly. In this review, we first provide an overview of the results of clinical studies that have analyzed the healthy macular choroid and that in various chorioretinal diseases, and then summarize the current understanding of the choroid outside the macula. We also examine the CT profile as an index that encompasses both within and outside of the macula. Furthermore, we describe the clinical applications of ultrawide OCT, which enables visualization of the far periphery, and discuss the prospects for the development of more reliable choroidal parameters that can better reflect the choroid's characteristics.

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Evaluation of macular and peripapillary choroidal thickness, macular volume and retinal nerve fiber layer in acromegaly patients

Cited by 11 publications

References 23 publications

Evaluation of the retinal layers and microvasculature in patients with acromegaly: a case-control OCT angiography study

Evaluation of the retinal layers and microvasculature in patients with acromegaly: a case-control OCT angiography study

Gene expression levels of the insulin-like growth factor family in patients with AMD before and after ranibizumab intravitreal injections

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

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