Evaluation of magnetic resonance angiography as a possible alternative to rotational angiography or computed tomography angiography for assessing cerebrovascular computational fluid dynamics

Yoneyama, Yuya; Isoda, Haruo; Ishiguro, Kenta; Tomita, Masaki; Kamiya, M.; Otsubo, K.; Perera, Roshani; Mizuno, Takashi; Fukuyama, Atsushi; Takiguchi, Kazuya; Watanabe, Tomoya; Kosugi, Tadayoshi; Komori, Yoshiaki; Naganawa, Shinji

doi:10.1007/s13246-020-00936-6

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Previous studies have demonstrated the variances in CFD simulation results of IAs among CTA, TOF-MRA, and 3DRA models, which might be due to unique geometric characteristics for different imaging modalities 24–26. In this study, hemodynamic differences were also detected between silent MRA and 3DRA models.…”

Section: Discussionsupporting

confidence: 48%

Non-contrast enhanced silent MR angiography to evaluate hemodynamics and morphology of unruptured intracranial aneurysms: a comparative computational fluid dynamics study

Leng²,

Zou³

et al. 2022

J NeuroIntervent Surg

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BackgroundSilent MR angiography (silent MRA) is a new generation of non-contrast enhanced angiography with outstanding advantages in visualizing cerebrovascular lesions and the follow-up after endovascular treatment for intracranial aneurysms (IAs). This study aims to investigate the reliability of silent MRA-based three-dimensional (3D) geometric description and hemodynamic calculation of IAs.Methods19 patients with 23 unruptured IAs, who underwent both silent MRA and 3D rotational angiography (3DRA), were included in this study. Computational fluid dynamics simulations were performed on all patient-specific 3D reconstruction images to compare the morphology and hemodynamics of the two different imaging models for IAs.ResultsSilent MRA models had smaller maximum and perpendicular height (mm), aneurysmal surface area (mm2), and aneurysmal volume (mm3) than 3DRA (p<0.05); the differences of the above parameters between the two models were 9.0±6.2%, 7.7±7.4%, 15.9±13.0%, and 21.4±17.5%, respectively. However, correlation analysis of morphological parameters in various dimensions and model comparison showed good overall consistency in geometrical characteristics between the two models. Moderate coherence was observed between models in time-averaged wall shear stress of aneurysm and parent vessel (TAWSS, PAWSS), aneurysm velocity (AV), parent vessel velocity, and oscillatory shear index (OSI). However, strong correlations were observed among normalized aneurysm wall shear stress (NWSS), low shear area (LSA), inflow concentration index (ICI), and normalized aneurysm velocity (NAV).ConclusionBoth morphological and hemodynamic assessments of IAs for silent MRA are comparable to 3DRA. Additionally, normalized indicators such as NWSS, LSA, ICI, and NAV were better than TAWSS, AV, and OSI in silent MRA-related hemodynamic evaluation.

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Section: Discussionsupporting

confidence: 48%

Non-contrast enhanced silent MR angiography to evaluate hemodynamics and morphology of unruptured intracranial aneurysms: a comparative computational fluid dynamics study

Leng²,

Zou³

et al. 2022

J NeuroIntervent Surg

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“…With the scalars from patient-specific computational fluid dynamics (CFD) simulation, the values of area under receiver-operating characteristic (ROC) curve (AUC) ranged from 0.820 to 0.967 (Fujimura et al, 2018;Misaki et al, 2021;Nambu et al, 2019;Umeda et al, 2017). The 3D information, however, was suppressed following averaging or maximizing, and its fidelity was strongly influenced by the accuracy of the geometry, boundary conditions, and parameters of the model in CFD simulation (Chnafa et al, 2018;Hoi et al, 2006;Lim et al, 2020;Steinman et al, 2019;Yoneyama et al, 2020) and the resolution in non-invasive measurement (Brindise et al, 2019;Roloff et al, 2019). This uncertainty resulted in "confounding factor dissemination" when quantifying clinical issues with hemodynamic parameters (Kallmes, 2012;Rayz et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Prediction of post-embolization recurrence in internal carotid-posterior communicating aneurysms with Vel-PointNet

Liao

Sakamoto

Misaki

et al. 2023

JBSE

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Prediction models for post-embolization recurrence with hemodynamic parameters from computational fluid dynamics (CFD) were widely studied to manage cerebral aneurysms. However, only spatiotemporally averaged or maximal scalars were used to develop the models. The hemodynamic information was suppressed from 3-dimensional (3D) to 0D after averaging or maximizing, and its fidelity was strongly dependent upon the accuracy of geometry, boundary conditions, and model parameters in CFD. We designed a deep learning network, Velocity-PointNet (Vel-PointNet), to predict the recurrence probability by extracting 3D morphological and hemodynamic features in aneurysm. Geometries of 52 internal carotid-posterior communicating (ICPC) aneurysms (eight recanalized and 44 stable) were acquired from our clinical study. The blood flow was simulated using CFD. Vel-PointNet was trained with 3D morphological-hemodynamic data from CFD results. Our Vel-PointNet model was compared to existing machine learning (ML) models using significant morphological-hemodynamic scalars to verify our assumption regarding the advantage of 3D features over 0D features. Furthermore, the performance of ML models trained with morphological scalars and conventional PointNet that extracted 3D morphological features was evaluated to verify importance of hemodynamic parameters in predictive models. The area under receiver-operating characteristic curve (AUC) and precision recall curve (AUPRC) of Vel-PointNet (1.000/1.000) was higher than the other models. As a result of extracting both morphological and hemodynamic features in 3D, Vel-PointNet was found to be more accurate than traditional approaches at predicting post-embolization recurrence of ICPC aneurysms.

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“…9 At the carotid bifurcation, 10 the unique geometric shape produces disordered hemodynamics, with a strong turbulence characteristic of disturbed flow, which plays a major role in the cause of intimal hyperplasia and atherosclerosis. 11 Currently, most research on carotid artery mechanics is based on computer model reconstruction, fluid dynamics analysis, image data post-processing, and in vitro material simulation techniques, [12][13][14][15] and so on. Nevertheless, not only are substantial individual differences found in the anatomical structure and course of carotid bifurcation, 16 but the establishment of an arterial wall model under physiological conditions still requires further exploration, while the blood flow belongs to non-Newtonian fluid, 17 which limits the accurate quantification of hemodynamics.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical characteristics in the carotid artery: Noninvasive assessment using subharmonic emissions from microbubbles

Zhang

Zheng

et al. 2023

Medical Physics

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BackgroundStroke is closely related to carotid atherosclerotic plaques, which tend to occur in specific parts of the arteries, especially at the bifurcations, and are considered to be caused by biomechanical factors. Quantitative analysis of hemodynamic stress characteristics of the carotid sinus in vivo provides a mechanical basis for the development of atherosclerotic plaque in the carotid sinus. Previous studies found that ultrasound (US) contrast agent microbubbles would vibrate nonlinearly under the excitation of sound pressure, generating subharmonics (transmission fundamental frequency, i.e., f0 and subharmonic frequency at f0/2), which have the highest sensitivity to pressure changes and exhibit an inverse linear relationship with environmental pressure.PurposeThis study employed subharmonic aided pressure estimation (SHAPE) technology to reflect carotid artery hydrodynamic characteristics in the carotid lumen.MethodsFrom May 2021 to December 2021, this prospective study reviewed a total of 26 normal carotid arteries of 13 participants, all of whom received bilateral carotid artery routine US and SHAPE US examinations. During this study, the lumen of the bilateral distal segment of the common carotid artery (Distal‐CCA), carotid artery bifurcation (CAB), and carotid bulb (CB) were scanned section by section from bottom to top in longitudinal and transverse sections. Subsequently, the subharmonic amplitudes in the lumen of normal carotid arteries were collected and analyzed.ResultsThis study found that the amplitude of subharmonic amplitude in the carotid was distributed unevenly, with the amplitudes of subharmonic at the CAB being higher. Specifically, the subharmonic gradient of the carotid artery bifurcation apex plane was maximum (9.72 ± 4.31 dB), while the average subharmonic amplitude of the outer lateral layer of the carotid artery was higher (‐56.40 ± 6.31 dB) (p < 0.001).ConclusionThe SHAPE technique is capable of indirectly reflecting the pressure changes of vascular system tissues, which may provide a new monitoring method for evaluating mechanical characteristics obviating invasion.

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Evaluation of magnetic resonance angiography as a possible alternative to rotational angiography or computed tomography angiography for assessing cerebrovascular computational fluid dynamics

Cited by 4 publications

References 15 publications

Non-contrast enhanced silent MR angiography to evaluate hemodynamics and morphology of unruptured intracranial aneurysms: a comparative computational fluid dynamics study

Non-contrast enhanced silent MR angiography to evaluate hemodynamics and morphology of unruptured intracranial aneurysms: a comparative computational fluid dynamics study

Prediction of post-embolization recurrence in internal carotid-posterior communicating aneurysms with Vel-PointNet

Biomechanical characteristics in the carotid artery: Noninvasive assessment using subharmonic emissions from microbubbles

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