Evaluation of Magnetic Resonance Signal Intensity in Bone Marrow after Administration of Super Paramagnetic Iron Oxide (SPIO)

Kotoura, Noriko; Saito, Kiyoshi; Fukuda, Yuko; Ishikura, Reiichi; Enoki, Takuya; Yamashita, Tatsuya; Nakae, Yasuo

doi:10.6009/jjrt.67.212

Cited by 4 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lack of focal or diffuse signal loss signalizes an infiltration by malignant cells also in this case [84]. In addition, differences in the signal behavior of inflammatory medullary cavity lesions (os- teomyelitis) and irradiated, hematopoietic, or reconverted bone marrow compared to normal or metastatic bone marrow after SPIO application are described [85].…”

Section: Bone Marrow Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

125

101

View full text Add to dashboard Cite

Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based ?NMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy. Key Points: Citation Format:

show abstract

Section: Bone Marrow Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

125

101

View full text Add to dashboard Cite

show abstract

“…The passive uptake of SPIO in the mononuclear phagocyte system or reticuloendothelial system after intravenous application has been shown to increase the sensitivity of detecting metastasis in the liver (50), the spleen (51), lymph nodes (52), and bone marrow (53). …”

Section: Dynamic Contrast-enhanced Mri and Mr Contrast Agentsmentioning

confidence: 99%

Functional MR Imaging Techniques in Oncology in the Era of Personalized Medicine

Benz

Vargas

Sala

2016

Magnetic Resonance Imaging Clinics of North America

View full text Add to dashboard Cite

SYNOPSIS DW and DCE MRI already contribute significantly to several aspects of personalized cancer medicine, namely diagnosis, treatment planning, response assessment, and prognosis. Nevertheless, the need for further standardization of theses imaging techniques is beyond question, and needs to be addressed. Whole body DW MRI is an exciting field, however future studies need to investigate in more depth the biologic significance of the findings depicted, their prognostic relevance and cost effectiveness in comparison to MDCT and PET/CT. New MR imaging probes such as targeted or activatable contrast agents and dynamic nuclear hyperpolarization show great promise to further improve the care of cancer patients in the near future.

show abstract

“…This is usually suggestive of infection or severe inflammatory spondyloarthropathy [43]. However this is a research application and unlikely to come into routine practice soon or indeed ever [44–46]. …”

Section: Mrimentioning

confidence: 99%

Imaging in rheumatology: reconciling radiology and rheumatology

Tins

Butler

2013

Insights Imaging

View full text Add to dashboard Cite

Imaging in rheumatology was in the past largely confined to radiographs of the hands and sacroiliac joints (SIJs) helping to establish the diagnosis and then monitoring disease progression. Radiographs are not very sensitive for early inflammation in inflammatory rheumatic disorders and the demand on imaging services was therefore limited. However, over the last 10–15 years new drugs and new technologies have brought new challenges and opportunities to rheumatology and radiology as specialties. New drug treatments allow more effective treatment, preventing many complications. Early diagnosis and disease monitoring has become the challenge for the rheumatologist and radiologist alike. The best possible patient outcome is only achieved if the two specialties understand each other’s viewpoint. This article reviews the role of imaging—in particular radiography, magnet resonance imaging, computer tomography, ultrasound and nuclear medicine—for the diagnosis and monitoring of rheumatological disorders, concentrating on rheumatoid arthritis, inflammatory spondylarthropathies and gout.Teaching Points• New drugs for the treatment of inflammatory disorders has led to greatly improved outcomes.• Imaging often allows for earlier diagnosis of inflammatory disorders.• Early diagnosis and treatment can often prevent the development of crippling disease manifestations.• Tailored imaging examinations are best achieved by consultation of rheumatologist and radiologist.

show abstract

Evaluation of Magnetic Resonance Signal Intensity in Bone Marrow after Administration of Super Paramagnetic Iron Oxide (SPIO)

Cited by 4 publications

References 11 publications

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Functional MR Imaging Techniques in Oncology in the Era of Personalized Medicine

Imaging in rheumatology: reconciling radiology and rheumatology

Contact Info

Product

Resources

About