Evaluation of Manuka Honey Estrogen Activity Using the MCF-7 Cell Proliferation Assay

Henderson, Katheleen; Aldhirgham, Tahrir; Nigam, Poonam Singh Nee; Owusu‐Apenten, Richard

doi:10.9734/jabb/2016/29887

Cited by 8 publications

(7 citation statements)

References 37 publications

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“…A recent in vitro study involving MCF-7 cell cultures found that, at low concentrations, Manuka honey contributed oestrogenic effects by stimulating cell growth (oestrogen agonist). However, high concentrations of Manuka honey inhibited cell growth by exerting cytotoxic effects [62]. This finding was supported by a previous study, which claimed that phyto-oestrogens posed biphasic oestro-genic effects that are known as oestrogenic and antiestrogenic properties.…”

Section: Honeybeesupporting

confidence: 72%

“…Therefore, the potential oestrogenic effects of these compounds are comparable with those of other xeno-oestrogens, such as BPA [74]. A recent study by Henderson et al showed that Manuka honey exerted oestrogenic effects on MCF-7 breast cancer cells [62]. Notably, another study demonstrated that honey showed inhibitory effects on the breast cancer cell lines MCF-7 and MCF-10A by inducing cytotoxicity and genotoxicity [75].…”

Section: Role Of Honey Against Toxicity In the Reproductive Systemmentioning

confidence: 95%

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Protective Roles of Honey in Reproductive Health: A Review

2021

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Nowadays, most people who lead healthy lifestyles tend to use natural products as supplements, complementary medicine or alternative treatments. Honey is God’s precious gift to mankind. Honey has been highly appreciated and extensively used since ancient history due to its high nutritional and therapeutic values. It is also known to enhance fertility. In the last few decades, the important role of honey in modern medicine has been acknowledged due to the large body of convincing evidence derived from extensive laboratory studies and clinical investigations. Honey has a highly complex chemical and biological composition that consists of various essential bioactive compounds, enzymes, amino and organic acids, acid phosphorylase, phytochemicals, carotenoid-like substances, vitamins and minerals. Reproductive health and fertility rates have declined in the last 30 years. Therefore, this review aimed to highlight the protective role of honey as a potential therapeutic in maintaining reproductive health. The main role of honey is to enhance fertility and treat infertility problems by acting as an alternative to hormone replacement therapy for protecting the vagina and uterus from atrophy, protecting against the toxic effects of xeno-oestrogenic agents on female reproductive functions and helping in the treatment of gynaecological disorders, such as vulvovaginal candidiasis infection, that affect women’s lives.

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Section: Honeybeesupporting

confidence: 72%

Section: Role Of Honey Against Toxicity In the Reproductive Systemmentioning

confidence: 95%

Protective Roles of Honey in Reproductive Health: A Review

2021

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“…Further investigation to identify the constituents in the active honey samples revealed that phenolic compounds such as rosmarinic acid, tannic acid, caffeic acid, coumaric acid, gallic acid, ferulic acid, syringic acid, catechin, and pyrogallol were present [100]. Meanwhile, manuka honey is reported to actively inhibit the proliferation of MCF-7 at various concentrations [101][102][103][104]. Acacia honey also exhibited anticancer activity against MCF-7 at a concentration of 5.5% v/v [105].…”

Section: Anticancer Properties Of Bee Productsmentioning

confidence: 99%

Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties

et al. 2021

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Bee products have long been used in traditional healing practices to treat many types of disorders, including cancer and microbial-related diseases. Indeed, several chemical compounds found in bee products have been demonstrated to display anticancer, antibacterial, antiviral, and antiparasitic properties. With the improvement of research tools and in view of recent advances related to bee products, this review aims to provide broad yet detailed insight into the pharmaceutical prospects of bee products such as honey, propolis, bee pollen, royal jelly, bee bread, beeswax, and bee venom, in the domain of cancer and infectious disease management. Available literature confirms the efficacy of these bee products in the alleviation of cancer progression, inhibition of bacterial and viral proliferation, and mitigation of parasitic-related symptoms. With such potentials, bioactive components isolated from the bee products can be used as an alternative approach in the long-run effort to improve humans’ health at a personal and community level.

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“…Manuka honey shows antioxidant and anticancer properties, which are considered due to its constituents-phytochemicals working as active bio-compounds [18]–[20]. A detailed in vitro study reported that the total phenol content and the antioxidant activity of Manuka honey influences the cytotoxic effects on MCF-7 cells [13].…”

Section: Honey's Use In Alternative Therapymentioning

confidence: 99%

Antibacterial activity of Manuka honey and its components: An overview

et al. 2018

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The importance of honey for medicinal purposes is well documented in some of the world's oldest literature. Honey is well known and studied for its antimicrobial properties. The medicinal properties in honey originate from the floral source used by bees. Manuka honey is a dark monofloral honey rich in phenolic content, and currently it is gaining much attention for its antimicrobial activity. Researchers have found that honey is effective against a wide range of pathogens. The antibacterial potency of Manuka honey was found to be related to the Unique Manuka Factor (UMF) rating, which is correlated with the methylglyoxal and total phenols content. It is reported that different types of Manuka honey have differing effects and Gram-negative bacteria are more resistant than Gram-positive bacteria. Bacterial resistance to honey as antimicrobial agent has yet to be identified, possibly due to the presence of a complex mixture of methylglyoxal and other components. Honey is also reported to alter a bacterium's shape and size through septal ring alteration, which affects cell morphology and growth. Research has shown that Manuka honey of different UMF values has medicinal properties of interest and it can be beneficial when used as a combination treatment with other antimicrobial agents.

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Evaluation of Manuka Honey Estrogen Activity Using the MCF-7 Cell Proliferation Assay

Abstract: Aims: To assess the estrogenic activity of Manuka honey using the MCF7 cell proliferation assay. Study Design: In vitro cell based E-screen.

Cited by 8 publications

References 37 publications

Protective Roles of Honey in Reproductive Health: A Review

Protective Roles of Honey in Reproductive Health: A Review

Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties

Antibacterial activity of Manuka honey and its components: An overview

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