Evaluation of mass transfer rate in aqueous two-phase systems: Effect of microchannel width for bovine serum albumin extraction

Raji, Farshad; Rahbar-Kelishami, Ahmad

doi:10.1016/j.cep.2021.108370

Cited by 25 publications

(9 citation statements)

References 36 publications

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“…It was also found that sulfur removal (i.e., extraction efficiency) is reduced by decreasing the microchannel length and increasing the RF/D. It should be noted that the residence time is defined by dividing the volume of the microchannel by the flow rates . The residence time is directly related to the microchannel length.…”

Section: Resultsmentioning

confidence: 99%

“…It should be noted that the residence time is defined by dividing the volume of the microchannel by the flow rates. 61 The residence time is directly related to the microchannel length. Therefore, an increase in the microchannel length results in an increase in the residence time and a subsequent increase in sulfur removal.…”

Section: Interaction Between Variables On the Responsementioning

confidence: 99%

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Extractive Desulfurization in Microchannel Contactors Using Deep Eutectic Solvents: Optimization Using Central Composite Design (CCD) and Flow Pattern Mapping

Mahdavi,

Sobati,

Movahedirad

2023

Energy Fuels

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In the present study, the optimization of extractive desulfurization in the microchannels was investigated using a deep eutectic solvent (DES). The influence of some operating and microchannel geometrical parameters, including the initial sulfur concentration of fuel, the length of the microchannel, the DES flow rate, and the ratio of fuel to DES flow rate (RF/D), on sulfur removal was investigated using response surface methodology (RSM). Moreover, the flow pattern map in the microchannels was investigated. In this regard, different flow patterns of slug, lengthy slug, smooth annular, throat annular, wavy annular, and droplet were observed in the microchannels applied in the extractive desulfurization (EDS) process. Besides, the effects of the inertial force, interfacial tension force, and viscosity force on the different flow patterns were discussed by analyzing the capillary number, the Weber number, and the Reynolds number. It was found that the most effective regime in the EDS process in the microchannel is the slug flow pattern in which the interfacial tension force (6 × 10 −5 < Weber number < 0.82767) is dominant. Based on the analysis of the RSM proposed model, it was also found that the RF/D is the main influential parameter on sulfur removal, and 73.2% sulfur removal was achieved in the microchannel under the optimum conditions in a very short residence time of 2.5 s. The results also confirmed the capability of this EDS process for sulfur removal from real diesel fuel.

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Section: Resultsmentioning

confidence: 99%

Section: Interaction Between Variables On the Responsementioning

confidence: 99%

Extractive Desulfurization in Microchannel Contactors Using Deep Eutectic Solvents: Optimization Using Central Composite Design (CCD) and Flow Pattern Mapping

Mahdavi,

Sobati,

Movahedirad

2023

Energy Fuels

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“…Moreover, this contact surface can be easily increased by simply carried out by changing the microchannel layout of the chip device. For example, Raji and Rahbar‐Kelishami [9] miniaturized a continuous aqueous two‐phase system into a chip device and constructed two interfaces between the BSA salt phase and polyethylene glycol polymer phase by one sample inlet channel and two sides polymer phase inlet channels. The doubled interfaces bring the advanced mass transfer of BSA from the salt phase to the polyethylene glycol phase, increasing the extraction rate.…”

Section: Microfluidic Sample Preparation Techniquesmentioning

confidence: 99%

Recent progress of microfluidic sample preparation techniques

Xia

2023

J of Separation Science

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Sample preparation turns out to be one of the important procedures in complex sample analysis by affecting the accuracy, selectivity, and sensitivity of analytical results. However, the majority of the conventional sample preparation techniques still suffer from time‐consuming and labor‐intensive operations. These shortcomings can be addressed by reforming the sample preparation process in a microfluidic manner. Inheriting the advantages of rapid, high efficiency, low consumption, and easy integration, microfluidic sample preparation techniques receive increasing attention, including microfluidic phases separation, microfluidic field‐assisted extraction, microfluidic membrane separation, and microfluidic chemical conversion. This review overviews the progress of microfluidic sample preparation techniques in the last 3 years based on more than 100 references, we highlight the implementation of typical sample preparation methods in the formats of microfluidics. Furthermore, the challenges and outlooks of the application of microfluidic sample preparation techniques are discussed.

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“…13 Nowadays, alcohol-based ATPS is more economically viable than IL-based ATPS because of the lower cost of alcohol and the ease of back-extraction of biomolecules from the alcohol-rich phase via evaporation. 14,15 This diversity of combinations allows the application of these systems in the partition and separation of various molecules, such as rutin, 16 caffeine, 17 flavones and sugars, 18 protein, 19 paracetamol, 20 lipase, 21 protease, 22 antibiotics 23 and Immunoglobulin G. 24 ATPSs usually have a neutral or slightly alkaline pH, 25 which is incompatible with a set of molecules that are soluble in aqueous solutions with a basic pH, such as humic acid, ibuprofen and paracetamol, 26 demonstrating the importance of constructing diagrams formed by hydroxides such as lithium (LiOH), sodium (NaOH) and potassium (KOH). Humic acids (HAs) belong to the family of humic substances (HS), produced by secondary reactions from the natural decomposition of plant and animal residues, resulting in a complex structure and relatively high molecular mass.…”

Section: Introductionmentioning

confidence: 99%

Partition of humic acids using alkaline aqueous two‐phase systems constituted of alcohol and hydroxides

Vieira,

Buarque,

Gomes

et al. 2024

J of Chemical Tech & Biotech

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BACKGROUNDHumic acids (HAs) are macromolecules classified within the group of humic substances that are mainly related to the agricultural and environmental sectors, but they have attracted interest from the medicine, pharmaceutical, and cosmetic industries. However, these latter sectors depend on developing extraction and purification technologies for adequate use. Thus, this paper aims to study the partitioning and recovery of HA using alkaline two‐phase aqueous systems (ATPSs) based on alkali metal‐based hydroxides and alcohols. Initially, the influence of alcohols (methanol, ethanol, 1‐propanol, and 2‐propanol) and hydroxides (NaOH, KOH, and LiOH) in the phase diagrams construction was addressed.RESULTSThe phase formation is correlated to an increase in the hydrophobicity of alcohols and hydroxides, which allows for the enlargement of the biphasic region. In the proposed systems, HA is always partitioned to the hydroxide‐rich phase. Increasing the hydrophobicity of the alcohol favors the migration of HA to the opposite phase, while increasing the hydrophilicity of the hydroxides leads to better partition and recovery values. It was observed that increasing TLL favors the recovery of HA. Furthermore, there was a decrease in alcohol concentration in the hydroxide‐rich phase with an increase in the alkyl chain and TLL, improving the recovery. Finally, the best reached‐recovery value was 98.18 ± 0.41% (KHA = 0.038 ± 0.02) for ATPS formed by 1‐propanol + NaOH with TLL ≈ 55 at 298 K.CONCLUSIONSThe alkaline systems can be a novel route for recovering humic substances from the environment.This article is protected by copyright. All rights reserved.

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Evaluation of mass transfer rate in aqueous two-phase systems: Effect of microchannel width for bovine serum albumin extraction

Cited by 25 publications

References 36 publications

Extractive Desulfurization in Microchannel Contactors Using Deep Eutectic Solvents: Optimization Using Central Composite Design (CCD) and Flow Pattern Mapping

Extractive Desulfurization in Microchannel Contactors Using Deep Eutectic Solvents: Optimization Using Central Composite Design (CCD) and Flow Pattern Mapping

Recent progress of microfluidic sample preparation techniques

Partition of humic acids using alkaline aqueous two‐phase systems constituted of alcohol and hydroxides

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