Evaluation of material properties and design requirements for biodegradable magnesium stents

Farè, S.; Ge, Qiang; Vedani, Maurizio; Vimercati, G.; Gastaldi, Dario; Migliavacca, Francesco; Petrini, Lorenza; Trasatti, Stefano P.

doi:10.1590/s1517-70762010000200002

Cited by 20 publications

(9 citation statements)

References 15 publications

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“…In fact, it has been suggested that there is a Hall-Petch-type relationship between corrosion rate and d M [85]. However, some results are inconsistent with this suggestion; for example, 1) for six alloys (WE43, AZ80, AZ61, AZ31, ZK60, and ZM21), the order of their corrosion rates in a static medium is different from the order of their corrosion rates in a hydrodynamic medium [86]; and 2) for an AZ31 components manufactured using equal channel angular pressing [85], which has a lower d M (∼2.5 μm) than its rolled counterpart, has a higher corrosion rate [63]. Two other phenomena that have been suggested for the decreased corrosion rate of an extruded specimen are high grain boundary density and high dislocation density [63].…”

Section: Manufacturing Processesmentioning

confidence: 99%

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Lewis¹

2016

WJET

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The most popular treatment/management modality for coronary artery disease, which is one of the leading causes of death, is percutaneous transluminal coronary intervention (popularly known as "plain old balloon angioplasty") followed by implantation of a stent ("stenting"). Stent types have evolved from bare metal stents through first-generation drug-eluting stents to fully bioresorbable stents (FBRSs). Two examples of FBRSs are 1) Mg scaffold with no coating; and 2) Mg alloy scaffold coated with a bioresorbable polymer in which an anti-proliferative drug is embedded. In the case of Mg/Mg alloy FBRSs, one of the reported clinical results is that the resorption time of the stent is too short (<∼4 mo to ∼12 mo), a consequence of the high corrosion rate of the metal/alloy. The present review article contains 1) a summarized but comprehensive comparison and contrast of all the types of stents, with special reference to Mg/Mg alloy FBRSs; 2) a critical review of the body of literature on methods to reduce the corrosion rate of Mg/Mg alloy specimens in various aqueous biosimulating media that may have implications for plain Mg/Mg alloy FBRSs, examples of such methods being alloy chemistry modification and fabrication using a nanocomposite; and 3) directions for future work on Mg/Mg alloy FBRSs that draw upon the findings highlighted in item (2) above as well as on other ideas, such as utilization of a Mg matrix composite and fabrication using a metal additive manufacturing method. Thus, information given in this review may find use in work on decreasing the in vivo resorption time (and, hence, improving the clinical efficacy) of the current generation of fully-bioresorbable Mg/Mg-alloy stents as well as guide the development of the next generation of these stents.

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Section: Manufacturing Processesmentioning

confidence: 99%

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Lewis¹

2016

WJET

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“…The main beneit of this class of materials is related to the fact that after the tissue has appropriately restored and they are no longer useful, the removal of follow-up surgery is avoided allowing higher protection since physical irritation and chronic inlammatory local reactions are totally excluded [45][46][47].…”

Section: Outlinementioning

confidence: 99%

Up-to-Date Knowledge and Outlooks for the Use of Metallic Biomaterials: Review Paper

Peter¹,

Matekovits²,

Rosso³

2018

Biomaterials in Regenerative Medicine

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In all cases, when a material has to be used in medical applications, the knowledge of its physical, chemical and biological properties is of fundamental signiicance, since the direct contact between the biological system and the considered device could generate reactions whose long-term efects must be clearly quantiied. The class of materials that exhibits characteristics that allow their use for the considered applications are commonly called biomaterials. Patients sufering from diferent diseases generate a great demand for real therapies, where the use of biomaterials are mandatory. Commonly, metallic biomaterials are used because their structural functions; the high strength and resistance to fracture they can ofer, provide reliable performance primarily in the ields of orthopedics and dentistry.In metals, because of their particular structure, plastic deformation takes place easier, inducing good formability in manufacturing. The present paper is not encyclopaedic, but reports in the irst part some current literature data and perspectives about the possibility of use diferent class of metallic materials for medical applications, while the second part recalls some results of the current research in this ield carried out by the authors.

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“…hardening model is, here we compare the best fit to experimentally obtained data (Association (nd); Fare et al (2010)). For this, the difference between the data and the model was treated as error to facilitate curve fitting.…”

Section: Hyperbolic Hardening Modelmentioning

confidence: 99%

Response and residual curvature of bent-stretched circular rods with applications to metal forming: Closed-form solutions for elastic-perfectly plastic and hyperbolic hardening materials

Bonfanti

Syngellakis

Bhaskar

2017

International Journal of Mechanical Sciences

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Response and residual curvature of bent-stretched circular rods with applications to metal forming: closed-form solutions for elastic-perfectly plastic and hyperbolic hardening materials, International Journal of Mechanical Sciences, http://dx.doi.org/10.1016Sciences, http://dx.doi.org/10. /j.ijmecsci.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractHere we develop an analytical expression for the curvature of rods of circular cross-section, when subjected to combined bending and axial force. Small deformations are assumed here so that the deflections are small compared to the cross-sectional dimensions. An enhanced material constitutive law having a linear elastic part followed by smoothly matched hyperbolic hardening is proposed. Analysis for two material models are presented which includes elastic-perfectly plastic material as well as hardening. The effects of the axial force on the response and springback are analytically assessed. The analysis is then applied to the bending of rods of circular cross-section. The analytical results are in excellent agreement with numerical calculations.

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Evaluation of material properties and design requirements for biodegradable magnesium stents

Cited by 20 publications

References 15 publications

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Up-to-Date Knowledge and Outlooks for the Use of Metallic Biomaterials: Review Paper

Response and residual curvature of bent-stretched circular rods with applications to metal forming: Closed-form solutions for elastic-perfectly plastic and hyperbolic hardening materials

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