Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation

Taglauer, Elizabeth; Dhole, Yashoda; Boateng, Jeffery; Snyder‐Cappione, Jennifer; Parker, Samantha E.; Clarke, Katherine; Juttukonda, Lillian J.; Devera, Jean; Hunnewell, Jessica; Barnett, Elizabeth D.; Jia, Hongpeng; Yarrington, Christina; Sabharwal, Vishakha; Wachman, Elisha M.

doi:10.1101/2021.12.26.472655

Cited by 2 publications

(1 citation statement)

References 30 publications

(30 reference statements)

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“…A total of 146 women with COVID-19 who delivered at BMC were identified during the recruitment period as described above (11). COVID-19 dyads with paired maternal blood and cord blood samples (n=30) at the time of delivery were analyzed as part of this pilot study.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Anti-SARS-CoV-2-Specific Antibody Signatures in Maternal and Infant Blood after COVID-19 Infection versus COVID-19 Vaccination during Pregnancy

Sabharwal,

Taglauer,

Demos

et al. 2023

Am J Perinatol

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Objective: The Advisory Committee on Immunization Practices and The American College of Obstetricians and Gynecologists recommend COVID-19 vaccine for pregnant persons to prevent severe illness and death. The objective was to examine levels of SARS-CoV-2 IgG, IgM, and IgA against spike protein Receptor Binding Domain (RBD) and nucleocapsid protein (NCP) in maternal and infant / cord blood at delivery after COVID 19 vaccination compared with SARS-CoV-2 infection at in mother infant dyads at specified time points. Study Design: Mothers with SARS-CoV-2 infection (n=31) or COVID-19 vaccination (n=25) during pregnancy were enrolled between July 2020 and November 2021. Samples were collected at delivery and IgG, IgM, and IgA to RBD of spike and nucleocapsid proteins compared in the infected and vaccinated groups. Timing of infection / vaccination prior to delivery and correlation with antibody levels was performed. Results: The majority of participants received vaccination within 90 days of delivery and over half received the Pfizer BioNTech vaccine. There were no significant correlations between antibody levels and timing of infection or vaccination. Infant IgG levels to the RBD domain of spike protein were higher in the vaccinated group (n=25) as compared to the infants born to mothers with infection (n=31). Vaccination against COVID-19 during pregnancy was associated with detectable maternal and infant anti-RBD IgG levels at delivery irrespective of the timing of vaccination. Conclusions: Timing of vaccination had no correlation to the antibody levels suggesting that the timing of maternal vaccination in the cohort did not matter. There was no IgM detected in infants from vaccinated mothers. Infants from vaccinated mothers had robust IgG titers to RBD, which have a lasting protective effect in infants.

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Section: Resultsmentioning

confidence: 99%

Comparison of Anti-SARS-CoV-2-Specific Antibody Signatures in Maternal and Infant Blood after COVID-19 Infection versus COVID-19 Vaccination during Pregnancy

Sabharwal,

Taglauer,

Demos

et al. 2023

Am J Perinatol

Self Cite

View full text Add to dashboard Cite

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Immune Responses to SARS-CoV-2 in Pregnancy: Implications for the Health of the Next Generation

Shook

Fourman

Edlow

2022

The Journal of Immunology

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Widespread SARS-CoV-2 infection among pregnant individuals has led to a generation of fetuses exposed in utero, but the long-term impact of such exposure remains unknown. Although fetal infection is rare, children born to mothers with SARS-CoV-2 infection may be at increased risk for adverse neurodevelopmental and cardiometabolic outcomes. Fetal programming effects are likely to be mediated at least in part by maternal immune activation. In this review, we discuss recent evidence regarding the effects of prenatal SARS-CoV-2 infection on the maternal, placental, and fetal immune response, as well as the implications for the long-term health of offspring. Extrapolating from what is known about the impact of maternal immune activation in other contexts (e.g., obesity, HIV, influenza), we review the potential for neurodevelopmental and cardiometabolic morbidity in offspring. Based on available data suggesting potential increased neurodevelopmental risk, we highlight the importance of establishing large cohorts to monitor offspring born to SARS-CoV-2–positive mothers for neurodevelopmental and cardiometabolic sequelae.

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Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation

Cited by 2 publications

References 30 publications

Comparison of Anti-SARS-CoV-2-Specific Antibody Signatures in Maternal and Infant Blood after COVID-19 Infection versus COVID-19 Vaccination during Pregnancy

Comparison of Anti-SARS-CoV-2-Specific Antibody Signatures in Maternal and Infant Blood after COVID-19 Infection versus COVID-19 Vaccination during Pregnancy

Immune Responses to SARS-CoV-2 in Pregnancy: Implications for the Health of the Next Generation

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