Evaluation of maternal serum ischemia modified albumin and total antioxidant status in ectopic pregnancy

Bozkaya, Giray; Karaca, İbrahim; Fenercioglu, Ozge; Karaca, Suna Yıldırım; Bilgili, Sibel; Uzuncan, Nuriye

doi:10.1080/14767058.2017.1422718

Cited by 9 publications

(4 citation statements)

References 30 publications

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“…Recently, the evaluation of AAIMA and its use to calculate the index of oxidation (IOS) was proposed as a marker of ectopic pregnancy. According to Bozkaya et al, a cut-off value of 0.545 for IOS has 81.6% sensitivity and 59.5% specificity for the prognosis of ectopic pregnancy [144]. This indicator can be especially important during an artificial insemination, as the frequency of ectopic pregnancy and spontaneous abortions in such patients remain high [152].…”

Section: Obstetrics and Gynecologymentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.

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Section: Obstetrics and Gynecologymentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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“…53 While there was no significant effect at the TAS level with propofol in the present study, the results suggest a specific effect of the anesthetic at the level of MDA mechanism in pregnant women who underwent CS. However, TAS is the result of overall contributions of several antioxidant mechanisms such as albumin, iron, bilirubin, uric acid; 54,55 and it is possible that all these variables were not affected considerably enough by the present CS/anesthetic paradigm.…”

Section: Discussionmentioning

confidence: 92%

Changes in blood oxidative stress biomarker and cholinesterase activity after general vs spinal anesthesia for elective cesarean sections

Karam,

Mohammad

2023

Anaesth. pain intensive care

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Background & Objective: There is an increased ratio of cesarean sections (CS) compared to normal deliveries the world over. Both general and regional anesthetic techniques are in practice for CS. Limited information is available on the determination of blood cholinesterase (ChE) activity in conjunction with oxidative stress biomarkers after the CS. The purpose of the present study was to determine and compare the plasma and erythrocyte ChE activity as well as malondialdehyde (MDA) level and total antioxidant status in pregnant women before anesthesia and after the use of general anesthesia (GA) or spinal anesthesia (SA) for elective CS. Methodology: A pre-post study was conducted on 102 full-term pregnant women, who underwent elective CS in four hospitals at Duhok (Iraq) from January 2022 to July 2022. GA with propofol and SA with bupivacaine 0.5% were administered to 52 and 50 women, respectively. Maternal blood samples before anesthesia and after the completion of operation were assayed for the ChE activity in the plasma and erythrocytes, and plasma oxidative stress biomarkers malondialdehyde and total antioxidant status. Results: Plasma ChE activity significantly decreased in the GA and SA groups after the cesarean-deliveries compared to the corresponding pre-anesthetic values. The plasma MDA level in both GA and SA groups, but not the total antioxidant status, was significantly reduced. Estimation of the odds ratio and the relative risk indicated that a risk factor is associated with the reduced plasma ChE activity in women after the CS when the general anesthetic propofol is used. Conclusion: Both general anesthesia with propofol and spinal anesthesia with bupivacaine inhibited plasma cholinesterase activity and reduced oxidative stress biomarker malondialdehyde after the cesarean sections. Abbreviations: CS - Cesarean section; ChE: Cholinesterase; EChE: Erythrocyte Cholinesterase; MDA: Malondialdehyde; OS: Oxidative Stress; PChE: Plasma ChE; TAS: Total Antioxidant Status. Key words: Anesthesia, Spinal; Cesarean section; General anesthesia; Malondialdehyde; Oxidative stress Citation: Karam RS, Mohammad FK. Changes in blood oxidative stress biomarker and cholinesterase activity after general vs spinal anesthesia for elective cesarean sections. Anaesth. pain intensive care 2023;27(3):396−404; DOI: 10.35975/apic.v27i3.2244 Received: March 23, 2023; Reviewed: May 06, 2023; Accepted: May 09, 2023

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“…Elevated levels of IMA have been observed in systemic sclerosis, diabetic ketoacidosis, acute ischemic stroke, and ectopic pregnancy. Therefore, its use as a biomarker is suitable [14][15][16][17][18]. The role of oxidative stress in endometriosis pathophysiology has already been established.…”

Section: Introductionmentioning

confidence: 99%

The role of dynamic thiol/disulfide homeostasis for the evaluation of oxidative stress in endometriosis patients

Selçuki¹,

Bahat²,

Kaya³

et al. 2022

Marmara Medical Journal

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Evaluation of maternal serum ischemia modified albumin and total antioxidant status in ectopic pregnancy

Abstract: According to our study, oxidative stress plays an important role in ectopic pregnancy and either A-IMA or IOS can be evaluated as a marker of ectopic pregnancy after further studies.

Cited by 9 publications

References 30 publications

Ischemia-Modified Albumin: Origins and Clinical Implications

Ischemia-Modified Albumin: Origins and Clinical Implications

Changes in blood oxidative stress biomarker and cholinesterase activity after general vs spinal anesthesia for elective cesarean sections

The role of dynamic thiol/disulfide homeostasis for the evaluation of oxidative stress in endometriosis patients

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