Evaluation of Medical Benefits of Coccinia Indica Through in-Silico Approach

Abstract

Coccinia indica is a vine that majorly grows in tropical climates. It is commonly used in south Asian cuisine and is known to show various medicinal properties. Various parts of the plant are used as a medicine such as roots, fruits and leaves. It is commonly known to cure disease such as liver disease, asthma, ulcer, urinary infection, allergy, bronchitis. In the current study, we try to understand the hepatoprotective and anti-arthritis of the plant via insilico docking methodologies. Firstly, the plant extract was subjected to GCMS analysis and the active components of the plant were obtained. The most reactive compounds amongst the result were chosen as ligands to conduct in-silico docking against the receptors of hepatoxicity and arthritis. Ligands like Pterin-6-carboxylic acid, 2r,3s-9-[[1,3-Dihydroxy-4-Fluoro-3-Butoxy]Methyl]Gu, D(17a)-Homo-C,18-dinorcard-20(22)-enolide, 14hydroxy-17a-methylene-3-oxo-, (5.beta.) -Showed potential interaction against chosen receptors. Coccinia indica active compound has shown better binding affinity between hepatotoxicity and arthritis receptors. The potential active compound of Coccinia indica can be further studied in animal models to demonstrate its beneficial activities.