Evaluation of melatonin and bromocryptine administration in Spanish goats

Wuliji, T.; Litherland, A. J.; Goetsch, A.L.; Sahlu, T.; Puchała, R.; Dawson, L.J.; Gipson, T.A.

doi:10.1016/s0921-4488(03)00055-5

Cited by 18 publications

(1 citation statement)

References 36 publications

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“…Domestication has led to an almost complete loss of seasonality in cattle, but it is retained in most breeds of sheep or goats [1]. At temperate latitudes, the reproductive activity of sheep is controlled mainly by the photoperiod and nutritional status of the organisms.…”

Section: Introductionmentioning

confidence: 99%

Seasonal and Nutritional Fluctuations in the mRNA Levels of the Short Form of the Leptin Receptor (LRa) in the Hypothalamus and Anterior Pituitary in Resistin-Treated Sheep

Biernat

Szczęsna

Kirsz

et al. 2021

Animals

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The short form of the leptin receptor (LRa) plays a key role in the transport of leptin to the central nervous system (CNS). Here, the resistin (RSTN)-mediated expression of LRa in the preoptic area (POA), ventromedial and dorsomedial nuclei (VMH/DMH),arcuate nucleus (ARC) and the anterior pituitary gland (AP)was analyzed considering the photoperiodic (experiment 1) and nutritional status (experiment 2) of ewes. In experiment 1, 30 sheep were fed normally and received one injection of saline or two doses of RSTN one hour prior to euthanasia. RSTN increased LRa expression mainly in the ARC and AP during long days (LD) and only in the AP during short days (SD). In experiment 2, an altered diet for 5 months created lean or fat sheep. Twenty sheep were divided into four groups: the lean and fat groups were given saline, while the lean-R and fat-R groups received RSTN one hour prior to euthanasia. Changes in adiposity influenced the effect of RSTN on LRa mRNA transcript levels in the POA, ARC and AP and without detection of LRa in the VMH/DMH. Overall, both photoperiodic and nutritional signals influence the effects of RSTN on leptin transport to the CNS and are involved in the adaptive/pathological phenomenon of leptin resistance in sheep.

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Section: Introductionmentioning

confidence: 99%