Evaluation of mesenchymal tumors of gastrointestinal tract with special reference to gastrointestinal stromal tumors – A tertiary care center experience

Patnayak, Rashmi; Jena, Amitabh; Prasad, PallaDurga; Rukhamangadha, Nandyala; Chowhan, Amit Kumar; Parthasarathy, Sriram; Reddy, Kumaraswamy

doi:10.5530/ogh.2013.1.16

Cited by 2 publications

(6 citation statements)

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“…3 In our study, male predominance was observed with a male-to-female ratio of 2:1, which was similar to the study done by Varsha et al, which had male to female ratio of 1.5:1. 7 Our finding was also comparable with other Indian studies by Patnayak et al and Rajappa et al 8,11 Global data showed equal distribution between males and females. 3 Gastrointestinal stromal tumors have varied clinical presentations like pain abdomen, mass per abdomen, and gastrointestinal bleeding.…”

Section: Clinical Presentationsupporting

confidence: 92%

“…The most common site was not similar to other Indian and global studies. 3,8,11 In our study, tumor size varied from 2.5 to 22 cm. Most GISTs had a size of more than 10 cm (57.1%), similar to the study done by Varsha et al and similar to data obtained from both Indian studies and global epidemiological data.…”

Section: Clinical Presentationmentioning

confidence: 69%

“…Of 28 cases of GIST, 25 cases showed both KIT and DOG 1 positivity (89.28%), 1 case showed only KIT positivity (3.57%), 1 case showed only DOG 1 positivity (3.57%), and 1 case was both c-KIT and DOG 1-negative (3.57%) (Table 4). [8][9][10] Global data had a higher median age of presentation of around 60 years. 3 In our study, male predominance was observed with a male-to-female ratio of 2:1, which was similar to the study done by Varsha et al, which had male to female ratio of 1.5:1.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Most GISTs had a size of more than 10 cm (57.1%), similar to the study done by Varsha et al and similar to data obtained from both Indian studies and global epidemiological data. 3,[7][8][9]11 Histologically maximum gastrointestinal stromal tumors commonly show spindle cell morphology. Spindle cell pattern was the most common histological pattern observed in this study and was present in 20 cases (71.4%) which was in concordance with studies by Varsha et al, Vij et al, Kim et al, and Lakshmi et al 7,[12][13][14] The epithelioid pattern was observed in 2 cases (7.1%), and mixed epithelioid and spindle cell pattern was observed in 6 cases (21.4%) which, in comparison to other studies, showed more cases of epithelioid morphology than mixed morphology.…”

Section: Clinical Presentationmentioning

confidence: 99%

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Histomorphological spectrum of gastrointestinal stromal tumors: an institutional experience

Nagaraju

Doddagowda²,

Anantharamiah³

et al. 2022

Int J Res Med Sci

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Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the abdominal area. They can involve any portion of the gastrointestinal (GI) tract, omentum, mesentery, retroperitoneum, and other sites. They form 1-2% of the histologic types of gastrointestinal tract tumors. Aims and objectives were to analyze and correlate morphological, clinical and histomorphology features of gastrointestinal tumors presenting at different sites.Methods: This was a retrospective observational study for six years. Medical records of the histopathologically diagnosed GIST cases were reviewed for patient demographics and clinical presentation, and tumor findings were noted.Results: Of the 28 patients, ages ranged from 28 to 80 years. Symptoms ranged from abdominal pain, epigastric discomfort, mass, upper/lower gastrointestinal bleeding, rectal bleeding, anemia, weight loss, and small bowel obstruction. Sites involved were the small bowel, stomach, mesentery, rectum, duodenum, greater omentum, and retroperitoneum. Of 28 cases of GIST, 25 cases showed both c-KIT and DOG-1 positivity, 1 case showed only c-KIT positivity, 1 case showed only DOG-1 positivity, and 1 case was both c-KIT and DOG-1 negative.Conclusions: GISTS are unpredictable mesenchymal tumors. Common sites are the stomach and small gut. Mesenteric and omental GIST are rare. Spindle cell morphology was more commonly present.

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Section: Clinical Presentationsupporting

confidence: 92%

Section: Clinical Presentationmentioning

confidence: 69%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

See 2 more Smart Citations

Histomorphological spectrum of gastrointestinal stromal tumors: an institutional experience

Nagaraju

Doddagowda²,

Anantharamiah³

et al. 2022

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…In a study conducted in our department, we have also encountered stomach as the most common site, followed by small intestine. [2] Majority of the patients belonged to fourth to the fifth decade of life. In our patients, gastrointestinal bleeding was a predominant finding.…”

Section: Sirmentioning

confidence: 99%