Evaluation of metabolic endpoints of acute cytotoxicity in V79 fibroblasts

Andreoli, Tiziana; Degan, B. Dal; Angelis, De; Fortunati, Elisabetta; Reggiani, Daniela; Bianchi, Vera; Tiozzo, Roberta; Zucco, Flavia

doi:10.1016/0887-2333(91)90091-q

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…In the case of BHA, however, it can directly damage cell membranes and inhibit cellular uptake of oxygen, leading to increased cell membrane permeability and cell death. 64 SAL reduces the activity of intracellular antioxidant system enzymes, leading to damage to biomolecules, such as proteins on cell membranes. This occurs due to the diminished capacity to scavenge intracellular reactive oxygen species (ROS) promptly, which, in turn, can cause elevated membrane permeability and apoptosis.…”

Section: Resultsmentioning

confidence: 99%

The key constituents underlying the combined toxicity of eight cosmetic contaminants towards Vibrio qinghaiensis

Zeng,

Zhang,

Zhou

et al. 2023

Environ. Sci.: Processes Impacts

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Section: Resultsmentioning

confidence: 99%

The key constituents underlying the combined toxicity of eight cosmetic contaminants towards Vibrio qinghaiensis

Zeng,

Zhang,

Zhou

et al. 2023

Environ. Sci.: Processes Impacts

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“…The Cr (VI) oxidation state is more toxic and mutagenic in nature [1][2][3][4][5][6][7] . Chromium has widespread industrial applications such as leather tanning, electroplating, textile dyeing, wood preservatives, paints, and cement industry.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Cr (VI) Oxyanions onto Modified Wood Pulp

Abdel-Halim

Abou‐Okeil

Hashem

2006

Polymer-Plastics Technology and Engineering

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A new adsorbent was prepared from wood pulp (WP) after reaction with epichlorohydrin and dimethylamine in the presence of pyridine and N,N-dimethylformamide (DMF). The adsorption of Cr (VI) from aqueous solutions by the so-prepared wood pulp adsorbent (WP-A) was investigated. Various factors affecting adsorption, such as pH, adsorbent concentration (1-5 g=L), agitation time (5-60 min), and Cr (VI) concentration (50-700), were taken into consideration. The adsorption of Cr (VI) onto (WP-A) was found to be pH-dependent and maximum adsorption was obtained at pH 3. The adsorption data obeyed Langmuir and Freundlich adsorption isotherms. The Langmuir adsorption capacity (Q max ) was found to be 588.24 mg/g. Freundlich constants, K F and n, were found to be 55.03 and 2.835, respectively.

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Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer

et al. 2014

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Occupational exposure to hexavalent chromium [Cr(VI)] has been firmly associated with the development of several pathologies, notably lung cancer. According to the current paradigm, the evolution of normal cells to a neoplastic state is accompanied by extensive metabolic reprogramming, namely at the level of energy-transducing processes. Thus, a complete understanding of the molecular basis of Cr(VI)-induced lung cancer must encompass the elucidation of the impact of Cr(VI) on metabolism. Research in this area is still in its infancy. Nonetheless, Cr(VI)-induced metabolic phenotypes are beginning to emerge. Specifically, it is now well documented that Cr(VI) exposure inhibits respiration and negatively affects the cellular energy status. Furthermore, preliminary results suggest that it also upregulates glucose uptake and lactic acid fermentation. From a mechanistic point of view, there is evidence that Cr(VI) exposure can interfere with energy transducing pathways at different levels, namely gene expression, intracellular protein levels and/or protein function. Loss of thiol redox control likely plays a key role in these processes. The transcriptional networks that control energy transduction can likewise be affected. Data also suggest that Cr(VI) exposure might compromise energy transducing processes through changes in the intracellular pools of their substrates. This article reviews, for the first time, the information available on Cr(VI) impact on mammalian cell bioenergetics. It aims to provide a framework for the understanding of the role played by bioenergetics in Cr(VI)-induced carcinogenesis and is also intended as a guide for future research efforts in this area.

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Evaluation of metabolic endpoints of acute cytotoxicity in V79 fibroblasts

Cited by 6 publications

References 12 publications

The key constituents underlying the combined toxicity of eight cosmetic contaminants towards Vibrio qinghaiensis

The key constituents underlying the combined toxicity of eight cosmetic contaminants towards Vibrio qinghaiensis

Adsorption of Cr (VI) Oxyanions onto Modified Wood Pulp

Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer

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