Evaluation of metal release and local tissue response to indigenous stainless steel miniplates used in facial fractures

Dugal, Arun; Dadhe, Dattaprasad P

doi:10.1007/s12663-009-0083-y

Cited by 2 publications

(4 citation statements)

References 7 publications

(12 reference statements)

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“…Also; metal ion release into tissue around stainless steel has been noted earlier [5]. While the observations by Dugal et al [16] are contradictory stating that local tissue response to stainless steel mini plates with short term residence (up to one year) in human body does not have any local response and wear debri release in the peri-prosthetic tissue. In this context, there is a need for an investigation into the cellular and molecular events taking place at the interface of the metal plates and screws which are allowed to reside life time in the patient without clinical symptoms and would pave way to identify a potential indicator/biomarker to decide upon removal of long term resident fracture fixation plates.…”

Section: Resultsmentioning

confidence: 96%

TLR-4 expression in corrosion metal debri induced hypoxic milieu around stainless steel fracture plates

Vaishnavi

Joseph

Prasanth

et al. 2018

Biomed. Phys. Eng. Express

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The release of corrosion debris from metallic implants leading to adverse tissue reactions and pain has jeopardized the lives of patients. This study attempts to observe if this holds true for widely used cost efficient stainless steel fracture plates and screws by studying the microenvironment in the peri prosthetic tissue of the retrieved implants. Fracture plates and nails along with adjacent tissues were collected in 10% neutral buffered formalin. Cellular response was qualitatively evaluated using HE staining and debris distribution was semi-quantitatively graded. Elemental composition of metallic debris was analysed by ESEM-EDAX of the tissue sections. The presence of macrophages, endothelial cells, TLR-4 and HIF-1α were quantitated by Immunohistochemistry and histomorphometry. Analysis of TLR-4 gene expression was carried out by real time PCR and the presence of a hypoxic milieu was confirmed by PCR Array. This study demonstrates the corrosion debris initiated chronic inflammatory reaction to stainless steel fracture plates. Nickel and Chromium ions released from implants induce a hypoxic environment resulting in TLR-4 induction. These results emphasize the need for identification of potential biomarker that could serve as a deciding factor for removal of stainless steel fracture plates from patients prior to the onset of inflammation associated reaction and also suggest the use of better manufacturing techniques and newer bio resorbable implants.

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Section: Resultsmentioning

confidence: 96%

TLR-4 expression in corrosion metal debri induced hypoxic milieu around stainless steel fracture plates

Vaishnavi

Joseph

Prasanth

et al. 2018

Biomed. Phys. Eng. Express

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“…The screws analyzed in this study showed regular surfaces. Thus, one can expect better results in terms of cell adhesion in these materials 9 .However, it is worth noting that other factors also affect cell adhesion and the biocompatibility of a material, such as its chemical composition 7 .This fact points out that the surface regularity of data should not be analyzed in isolation. The mapping of the components allows us to reveal the elements distributed along the external surfaces of the materials, which can maintain direct contact and influence the characteristics of the tissues' biological responses.…”

Section: Chemical Elementsmentioning

confidence: 99%

“…Since its introduction in maxillofacial surgery and traumatology, internal fixation plates and screws have been the subject of numerous studies that have focused on the analysis of their physical-chemical and biological properties [7][8][9] . The interaction of the surgical material with the soft and hard tissues that surround it is strongly influenced by the characteristics of its surface and by its chemical composition 6 .…”

Section: Introductionmentioning

confidence: 99%

“…The chemical composition of the material used in the internal fixation, as distributed at the level of its surface structure, can characterize different properties since this surface allows interaction between the material and the tissues with it has contact 7 .Biocompatibility can be directly affected by the chemical composition of the material, since the presence of compounds that irritate the tissues reduces the tissue tolerance tothe material 7 .In this way, knowledge of the chemical composition of the internal fixation materials can favor understanding of their biological and physical-chemical properties 13 .A limited amount of information is available about the chemical constitution and the characteristics of the external surfaces of plates and screws before their surgical use. Thus, the present study aimed to evaluate the morphology of the external surface and the chemical constitution of plates and screws used to fix facial fractures.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical and Structural Evaluation of Internal Fixation Materials for Facial Fractures

Tomáz¹,

Oliveira²,

Aranha³

et al. 2020

IJAERS

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Oral and maxillofacial injuries often result in fractures tofacial bones. The treatment of facial fractures involves the use of plates and screws for internal fixation. This study was aimedatanalyzing the surface morphology and chemical constitution of internal fixation materials used to treatfacial fractures through scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis. Twenty-seven plates and 21 screws were distributed in six experimental groups: Group 1-Toride ® ; Group 2-Engimplan ® ; Group 3-MDT ® ; Group 4-Promm ® ; Group 5-Osteomed ® andGroup 6-Stryker ® . The samples underwent SEM, andthe external surface morphology was analyzed qualitatively in images obtained with a magnification of 30-1000X. The surface was described according to its regularity (regular or irregular) and concerning the presence of defects (scratches, corrosion, metal fragments, metal deformation or protuberance [burrs]). Constitutive analysis was made through EDX. The chemical elements were quantified and presented asatomic weight percentages (%p). All the plates presented external surfaces with irregular aspects. Defects were not observed only in Osteomed ® and Stryker ® plates. The main components found in the plates were titanium (Ti), silicon (Si) and aluminum (Al). The element phosphorous (P) was found only in Stryker ® plates. The screws presented regular surfaces and defects onthe head and threads. Most of the screws presented Ti and Al peaks. Traces of vanadium (V) were identified in the Stryker ® and Toride ® screws. The Promm ® screws were made of Ti. The analyzed plates and screws presented surfaces with different aspects and defects. Some of the chemical elements found in the plates and screws were not described by their manufactures.

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Evaluation of metal release and local tissue response to indigenous stainless steel miniplates used in facial fractures

Cited by 2 publications

References 7 publications

TLR-4 expression in corrosion metal debri induced hypoxic milieu around stainless steel fracture plates

TLR-4 expression in corrosion metal debri induced hypoxic milieu around stainless steel fracture plates

Chemical and Structural Evaluation of Internal Fixation Materials for Facial Fractures

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