Evaluation of Methanolic Extract of Clitoria ternatea Hepatoprotective & Nephroprotective Activity in Rats

Abstract

Objective: The aim of the study was to investigate the nephroprotective & hepatoprotective activity of methanolic extract of Clitoria ternatea in Cisplatin & CCl4 induced in rats
 Methods: Methanolic extract of aerial part of Clitoria ternatea plant was studied for its Nephroprotective & Hepatoprotective activity in animal experiment models. Nephrotoxicity was induced by Cystone 16 mg/kg b.w . Standard drug was taken Silymarin .Test drug were given methanolic extract Clitoria ternatea 500 mg/kg , 1000 mg/kg . Hepatoxicity was induced by CCl4 .Standard drug was taken cisplatin 100 mg/kg . Test drugs were given extract of Clitoria ternatea 500 mg/kg & 1000 mg/kg as per b.w
 Results : In Hepatoprotective activity positive control group was provided with CCl4 and increased SGPT , SGOT , ALP level compare to negative control group whereas Test(2) group was provided with methanolic extract of Clitoria ternatea 1000 mg/kg decreased SGPT , SGOT , ALP level compare to standard group. In nephroprotective activity positive control group was provided with CCl4 increased Urea and creatinine level where as Test(2) group are provided with methanolic extract of Clitoria ternatea 1000 mg/kg decreased urea and creatinine level
 Conclusion: On evaluating biochemical parameters it was found that methanolic extract of Clitoria ternatea 1000 mg/kg showed hepatoprotective and nephroprotective activity in rats. 
 Keywords: SGPT, SGOT, ALP, Nephroprotective, Hepatoprotective

Mapping Molecular Networks within Clitoria ternatea Linn. against LPS-Induced Neuroinflammation in Microglial Cells, with Molecular Docking and In Vivo Toxicity Assessment in Zebrafish

“…Specifically, these fragment ions appeared at m/z 107 [ 0,4 A] − and 151 [ 1,3 A] − for isorhamnetin, while at m/z 121 [ 0,4 A] − and 165 [ 1,3 A] − for rhamnetin. A further loss of a 15 Da (CH 3 ), accompanied by CO (28 Da) and HCO (29 Da), indicated the presence of methoxy group in their parent structures [30][31][32]. The spectra show cross-ring cleavage of the mono-methoxyl sub-structure, which can be seen from the proposed fragmentation mechanism in Figure 13B,C.…”

“…In addition, the ability of CT to treat CNS disorders, by acting as an anti-stress treatment, antidepressant, and anti-sedative, has been reported [29]. Moreover, the flower extract of CT has shown high potential as an anti-neuroinflammatory agent [30] without acute toxicity and significant hepatoprotective and nephroprotective effects in mice in vivo models [31][32][33][34]. Several studies have been conducted on CT in the past, but little useful information was gathered on the specific metabolites responsible for its medicinal potential.…”

The Traditional Uses, Phytochemistry, and Pharmacological Effects of Clitoria ternatea: A Review

“…Another preliminary phytochemical screening study reported the presence of tannin and glycosides, as well as small amounts of alkaloids, terpenoids, and phenols, in the methanolic extract of the leaf of C. ternatea. 18 Chandra et al 27 also showed the presence of flavonoids, alkaloids, glycosides, terpenes, carbohydrates, saponins, and sterols in the methanolic leaves extract of C. ternatea. A previous study on hydroalcoholic (10:90) leaves extract by Kaur et al 28 identified and reported the presence of alkaloids, flavanol glycosides, steroids, saponins, tannins, volatile oils, and carbohydrates.…”

Lipid Nano-System Based Topical Drug Delivery for Management of Rheumatoid Arthritis: An Overview

“…A recent study conducted by Mitra et al 32 was based on the development of Bee venom nanoemulsion which was evaluated for its penetration and activity to modulate serum levels of endothelin-1 (which is a pro-inflammatory factor that participates in RA pathogenesis) in Collagen-induced rheumatoid arthritis model and found to have good skin permeation and showed a decrease in serum level of endothelin-1, because of anti-oxidant, anti-inflammatory and immunomodulatory effect of bee venom. Loading Herbal drug extract in nanoemulsion is also found to be beneficial, Rajeshwar et al, 40 to reduce the dose of ginger extract, a potent antiinflammatory agent and to promote its drug delivery through the skin, incorporated ginger extract into a nanoemulsion and formulated as nanoemulgel which has improved transdermal absorption of the ginger extract. 40…”

“…Loading Herbal drug extract in nanoemulsion is also found to be beneficial, Rajeshwar et al, 40 to reduce the dose of ginger extract, a potent antiinflammatory agent and to promote its drug delivery through the skin, incorporated ginger extract into a nanoemulsion and formulated as nanoemulgel which has improved transdermal absorption of the ginger extract. 40…”