Evaluation of Methylthio-, Methylsulfinyl-, and Methylsulfonyl-Analogs of Alkanes and Alkanoic Acids as Cardiac Inotropic and Antifungal Agents

Iqbal, Nadeem; McEwen, Carol-Anne; Sardari, Soroush; Daneshtalab, Mohsen; Knaus, Edward E.

doi:10.1002/1521-4184(20009)333:9<293::aid-ardp293>3.0.co;2-2

Cited by 7 publications

(1 citation statement)

References 18 publications

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“…Among them, chlorothiolation of alkenes is a topic of current interest because sulfur-containing compounds are valuable synthetic intermediates and important building blocks and the chloro moieties can be converted into a wide variety of functional groups . Moreover, the chlorothiolation of alkenes has been shown to possess insecticidal, antibacterial, and antifungal properties …”

Section: Introductionmentioning

confidence: 99%

Regioselective Chlorothiolation of Alkenes with Sulfonyl Chlorides

et al. 2019

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Newly developed sulfonyl chloride-based regioselective chlorothiolation of alkenes has been disclosed; the reaction is compatible with a variety of functional groups and can be scaled up to the gram scale with no loss in yield. The employment of readily available reactants, mild reaction conditions, and high regioselectivity makes this process very practical. Mechanistic studies revealed a possible free radical reaction pathway.

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Section: Introductionmentioning

confidence: 99%

Regioselective Chlorothiolation of Alkenes with Sulfonyl Chlorides

et al. 2019

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Site‐Selective Pd‐Catalysed Fujiwara‐Moritani type Reaction of N,S‐Heterocyclic Systems with Olefins

et al. 2020

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Dihydro‐1,4‐thiazine skeletons bearing olefin fragment at their α‐position were prepared through a Pd(OAc)2‐catalysed Fujiwara‐Moritani type reaction via C−H alkenylation with olefins. This approach is selective, generalizable to a wide range of olefins and requires only 1 eq. of Ag2CO3 without the need of co‐oxidant. The C−H bond activation proved to be strongly dependent on the olefin's substitution while unfused dihydro‐1,4‐thiazines seemed to be affected by the oxidation state of the sulfur atom. The utility of olefins obtained was demonstrated by their implication in the dipolar cycloaddition reaction with a non‐stabilized azomethine ylide.

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