Evaluation of microhaemagglutination assay to determine treponemal antibodies in CSF.

Birry, A; Kasatiya, S. S.

doi:10.1136/sti.55.4.239

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Total protein concen tration in CSF was measured by the method of Lowry et al [1], Albumin and IgG in serum and CSF were analyzed nephelometrically. CSF/serum albumin ratio and CSF IgG index (CSF-IgG/ S-IgG)/(CSF-alb/S-alb) were calculated [2], CSF TPHA was deter mined with microhemagglutination assay [3]. IgG index and TPHA were determined in 98 cases, cell count and total protein in all patients.…”

Section: Methodsmentioning

confidence: 99%

Is Lumbar Puncture Indicated in Examination of Dizzy Patients?

Ojala¹

1989

Eur Neurol

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Routine cerebrospinal fluid (CSF) analysis was performed in 109 dizzy patients, who also had been examined by comprehensive neurological and otological methods. Altogether 31 patients (28%) had some abnormality in the CSF. These CSF findings, however, gave no clues as to the etiology of the symptom which could not be obtained by noninvasive methods as well. Hence, lumbar puncture is not recommended for the examination of dizzy patients.

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Section: Methodsmentioning

confidence: 99%

Is Lumbar Puncture Indicated in Examination of Dizzy Patients?

Ojala¹

1989

Eur Neurol

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“…In studies of definitive neurosyphilis, sensitivity of CSF FTA-ABS was 90.9%–100% ( 155 – 157 ). In the two largest studies of presumptive neurosyphilis (n = 60 and n = 156), CSF FTA-ABS demonstrated 100% sensitivity ( 158 , 159 ).…”

Section: Recommendations For Syphilis Testing In the United Statesmentioning

confidence: 99%

CDC Laboratory Recommendations for Syphilis Testing, United States, 2024

Papp,

Park,

Fakile

et al. 2024

MMWR Recomm. Rep.

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Summary This report provides new CDC recommendations for tests that can support a diagnosis of syphilis, including serologic testing and methods for the identification of the causative agent Treponema pallidum . These comprehensive recommendations are the first published by CDC on laboratory testing for syphilis, which has traditionally been based on serologic algorithms to detect a humoral immune response to T. pallidum . These tests can be divided into nontreponemal and treponemal tests depending on whether they detect antibodies that are broadly reactive to lipoidal antigens shared by both host and T. pallidum or antibodies specific to T. pallidum , respectively. Both types of tests must be used in conjunction to help distinguish between an untreated infection or a past infection that has been successfully treated. Newer serologic tests allow for laboratory automation but must be used in an algorithm, which also can involve older manual serologic tests. Direct detection of T. pallidum continues to evolve from microscopic examination of material from lesions for visualization of T. pallidum to molecular detection of the organism. Limited point-of-care tests for syphilis are available in the United States; increased availability of point-of-care tests that are sensitive and specific could facilitate expansion of screening programs and reduce the time from test result to treatment. These recommendations are intended for use by clinical laboratory directors, laboratory staff, clinicians, and disease control personnel who must choose among the multiple available testing methods, establish standard operating procedures for collecting and processing specimens, interpret test results for laboratory reporting, and counsel and treat patients. Future revisions to these recommendations will be based on new research or technologic advancements for syphilis clinical laboratory science.

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The significance of cerebrospinal fluid routine screening for neurosyphilis

Kinnunen

Hillbom

1986

Journal of the Neurological Sciences

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Evaluation of microhaemagglutination assay to determine treponemal antibodies in CSF.

Cited by 5 publications

References 15 publications

Is Lumbar Puncture Indicated in Examination of Dizzy Patients?

Is Lumbar Puncture Indicated in Examination of Dizzy Patients?

CDC Laboratory Recommendations for Syphilis Testing, United States, 2024

The significance of cerebrospinal fluid routine screening for neurosyphilis

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