Evaluation of Micronuclei in Oral Squamous Cell Carcinoma: A Cytological Study

Chaudhary, Monika; Ramesh, Vengalathur Ganesan; Oza, Nirima; Prashad, Karthikshree V; Malik, Sheetal

doi:10.5005/jp-journals-10051-0074

ijocrweb

2017

DOI: 10.5005/jp-journals-10051-0074

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Evaluation of Micronuclei in Oral Squamous Cell Carcinoma: A Cytological Study

Monika Chaudhary¹,

Vengalathur Ganesan Ramesh²,

Nirima Oza³

et al.

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2023

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Micronuclei detection in oral cytologic smear: does it add diagnostic value?

Elnaggar,

Madkour,

Tahoun

et al. 2023

J Egypt Natl Canc Inst

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Background Screening and early diagnosis of oral squamous cell carcinoma (OSCC) are directly associated with increased survival rate and improved prognosis. Noninvasive diagnostic tools have been implemented in the early detection as toluidine blue staining, optical imaging, and oral cytology. This study aimed to assess and compare the presence of micronuclei (MN) in oral exfoliative cytology of healthy controls, subjects exposed to high-risk factors for oral cancer, subjects with oral potentially malignant lesions (OPMLs), and those with malignant oral lesions. Subjects and methods A total number of 92 subjects were divided into 46 healthy controls with no oral mucosal lesions (23 with no evidence of cancer risk factors and 23 with cancer risk factors), 23 with OPMLs and 23 with oral malignant lesions. All the 92 participants were subjected to cytological sampling for detection of MN. The final diagnosis of the oral lesions was confirmed by the histopathological picture and compared to the cytological results. Results The results showed that the diagnostic accuracy of MN was higher in OPMLs group (95.2%). The sensitivity of MN test in malignant group was much lower (52.2%); however, all the cytological criteria of malignancy were markedly detected as compared to the OPMLs group. Conclusions Conventional oral cytology supported by MN is highly beneficial as adjunctive tool in the screening for early detection of dysplastic oral lesions.

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Micronuclei detection in oral cytologic smear: does it add diagnostic value?

Elnaggar,

Madkour,

Tahoun

et al. 2023

J Egypt Natl Canc Inst

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Evaluation of Micronuclei in Oral Squamous Cell Carcinoma: A Cytological Study

Cited by 1 publication

References 14 publications

Micronuclei detection in oral cytologic smear: does it add diagnostic value?

Micronuclei detection in oral cytologic smear: does it add diagnostic value?

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