Evaluation of microorganisms isolated from blood cultures and their susceptibility profiles to antibiotics in five years period

Arabacı, Çiğdem; Kutlu, Orkide

doi:10.28982/josam.626480

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…The most common causative agent after CA was C.parapsilosis with 17.2%. This result was consistent with other studies conducted in Turkey [14][15][16][17]. In our study, the third most common strain was C. glabrata (13.4%).…”

Section: Discussionsupporting

confidence: 93%

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Risk factors, clinical characteristics and mortality of candidemia in non-neutropenic, critically ill patients in a tertiary care hospital

Tümtürk¹

2020

Journal of Surgery and Medicine

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Aim: In recent years candida species have emerged as important nosocomial pathogens leading to increased mortality and prolonged hospitalization. In this study, we aimed to determine the distribution of Candida species in the intensive care unit (ICU) and to investigate the risk factors and mortality rates in Candida albicans (CA) and non-albicans Candida infections (NAC). Methods: This retrospective cohort study was conducted between January 2018 and January 2019. 134 patients hospitalized in the intensive care units with Candida reproduction in their blood cultures were included in the study. Blood cultures were processed, and strain distribution was performed according to routine practice using the automated blood culture system BACTEC 9240 (Becton Dickinson, Maryland, USA). Results: Candida growth was detected in the blood culture of 134 patients, among which 54.5% consisted of CA and 45.5% of NAC. NAC was most commonly followed by C. parapsilosis (17.2%), and C. glabrata (13.4%). Mortality rate of patients aged ≥60 years was significantly higher in all three candida species (P=0.003). NAC was seen at an insignificantly higher rate in patients with solid-organ malignancy (P=0.09). Although mortality was higher in CA than NAC strain (53.6% and 43.4%, respectively), this was not statistically significant (P=0.83). Conclusion: Although CA is still the most common strain in ICU patients, the incidence of NAC is increasing. Candidemia has high mortality rates in ICU patients. Especially elderly patients with underlying diseases should be followed carefully.

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Section: Discussionsupporting

confidence: 93%

“…There was no significant correlation between the distribution of candida species among surgical and non-surgical patients. Aliskan et al reported similar results in their study [14]. Candidemia has been reported to be the cause of mortality at a rate of 30-60% [25,10].…”

Section: Discussionsupporting

confidence: 69%

Risk factors, clinical characteristics and mortality of candidemia in non-neutropenic, critically ill patients in a tertiary care hospital

Tümtürk¹

2020

Journal of Surgery and Medicine

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“…In study conducted at academic medical centers in the United States between 2015 and 2019 showed most CRE were K. pneumoniae (63.2%), followed by E. coli (14.5%) concurrent to our study [18]. Similarly, Porwall et al identified the most common carbapenem resistant Gram negative isolate was CRKP (44%) followed by CREC (26%) [19].…”

Section: Discussionsupporting

confidence: 80%

Multidrug resistant pathogens and their antibiotic susceptibility profile isolated from blood stream infections in a tertiary care hospital

Pramodhini

2023

Microbes and Infectious Diseases

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Background: Increasing burden of hospital-acquired BSI caused by multidrug-resistant (MDR) pathogens are associated with poor patient outcome compared to susceptible bacteria. Objectives: The aim is to isolate and identify multidrug resistant (MDR) pathogens from positive blood cultures and to study their antibiotic resistant pattern. Methods: A cross sectional study was done on blood samples sent for culture and sensitivity. Identification and antibiotic susceptibility of isolated pathogens were done as per guidelines and Gram-negative bacteria resistance to at least one antibiotic in three or more antimicrobial classes was taken as MDR pathogen and further studied. Results: Out of 4770 blood samples were cultured, 78.3% were sterile and 7.2% were proven culture positive for pathogen. Among 342 positive blood culture, 88(25.7%) were MDR, 146 (42.7%) were ESBL producers and 76(22.2%) were carbapenem resistant isolates. Gram negative bacteria was predominantly isolated (83%) of which 67% of Klebsiella pneumoniae (K. pneumoniae), 57% of Acinetobacter baumanni (A. baumannii) were MDR pathogens. 75% of Klebsiella pneumoniae, 69% of Escherichia coli (E. coli), 50% of A. baumanni were screened positive for ESBL producers. Resistance to carbapenems were 64%, 50%, 31% and 6% for K. pneumoniae, A. baumannii, Pseudomonas aeruginosa and E. coli respectively. Conclusion: In our study, among 342 positive blood culture, 25.7% were MDR, 42.7% were ESBL producers and 22.2% were carbapenem resistant isolates. Measures to curtail the spread of MDR pathogen in the community settings and policies to adopt appropriate use of antibiotics in the hospital as well in the community need to be emphasized.

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“…In the national ARMOR surveillance study conducted in the USA, ciprofloxacin susceptibility was 94.9 % in 389 ocular P. aeruginosa strains [21]. Turkey-based studies have reported that susceptibility to ciprofloxacin was 51%-70% [12,22,23]. In this study, ciprofloxacin resistance (18.5%) was close to the empirical treatment limit (20%).…”

Section: Discussionsupporting

confidence: 53%

Bacterial profiles and antibiotic susceptibility pattern in patients with chronic dacryocystitis

Aşgın¹,

Çakmaklioğullari²

2020

Journal of Surgery and Medicine

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Evaluation of microorganisms isolated from blood cultures and their susceptibility profiles to antibiotics in five years period

Abstract: How to cite / Atıf için: Arabacı Ç, Kutlu O. Evaluation of microorganisms isolated from blood cultures and their susceptibility profiles to antibiotics in five years period.

Cited by 5 publications

References 30 publications

Risk factors, clinical characteristics and mortality of candidemia in non-neutropenic, critically ill patients in a tertiary care hospital

Risk factors, clinical characteristics and mortality of candidemia in non-neutropenic, critically ill patients in a tertiary care hospital

Multidrug resistant pathogens and their antibiotic susceptibility profile isolated from blood stream infections in a tertiary care hospital

Bacterial profiles and antibiotic susceptibility pattern in patients with chronic dacryocystitis

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