Evaluation of Microorganisms Isolated from Endotracheal Aspirate Cultures in Patients with and without COVID-19 in the Intensive Care Unit: Single-Centre Retrospective Analysis

Rollas, Kazım; Ersan, Gürsel; Emgin, Ömer; Çalışkan, Taner; Yavuz, Tunzala; Sarac, Omurhan

doi:10.37678/dcybd.2022.3156

Cited by 3 publications

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“…In another study from Türkiye, Rollas et al. reported Acinetobacter baumanii as the leading cause of VAP ( 21 ). Gram-negatives appeared to be the most predominant agents in COVID-19 patients with VAP.…”

Section: Methodsmentioning

confidence: 99%

Ventilator associated pneumonia in COVID-19 patients: A retrospective cohort study

et al. 2023

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Ventilator associated pneumonia in COVID-19 patients: A retrospective cohort study Introduction We aimed to evaluate ventilator-associated pneumonia (VAP) incidence rate, risk factors, and isolated microorganisms in COVID-19 patients as the primary endpoint. Evaluation of VAP-associated intensive care unit (ICU) and hospital mortalities was the secondary endpoint. Materials and Methods Records of patients admitted between March 2020- June 2021 to our pandemic ICU were reviewed and COVID-19 patients with VAP and non-VAP were evaluated retrospectively. Comorbidities, management, length of ICU stay, and outcomes of VAP and non-VAP patients, as well as risk factors for VAP mortality, were identified. Results During the study period, 254 patients were admitted to the ICU. After the exclusion, the data of 208 patients were reviewed. In total, 121 patients required invasive mechanical ventilation, with 78 (64.5%) developing VAP. Length of ICU and hospital stays were longer in VAP patients (p< 0.01 and p< 0.01 respectively). Steroid use was higher in VAP patients, although it was not statistically significant (p= 0.06). APACHE II score (p< 0.01) was higher in non-VAP patients. ICU mortality was high in both groups (VAP 70%, non-VAP 77%). VAP mortality was higher in males (p= 0.03) and in patients who required renal replacement therapy (p= 0.01). Length of ICU stay (p= 0.04), and length of hospital stay (p< 0.01) were both high in VAP survivors. The most common isolated microorganisms were Acinetobacter spp. and Klebsiella spp. in VAP patients and most of them were extensively drug-resistant. Conclusion Critically ill COVID-19 patients who required invasive mechanical ventilation developed VAP frequently. The length of ICU stay was longer in patients who developed VAP and ICU mortality was high in both VAP and non-VAP patients. The length of hospital and ICU stays among VAP survivors were also considerably high which is probably related to the long recovery period of COVID-19. The most frequently isolated microorganisms were Acinetobacter spp. and Klebsiella spp. in VAP patients

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Section: Methodsmentioning

confidence: 99%

Ventilator associated pneumonia in COVID-19 patients: A retrospective cohort study

et al. 2023

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Evaluation of Ventilator-Associated Pneumonia Risk Factors and Pathogens in COVID-19 Patients: A Retrospective Study

Yarimoglu

Yarımoğlu²

2023

Ankara Eğitim Ve Araştırma Hastanesi Tıp Dergisi

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Objective: Many patients followed in intensive care units during the COVID-19 pandemic required mechanical ventilation. In the present study, the purpose was to examine the risk factors, frequency, and causative pathogens of ventilator-associated pneumonia in COVID-19 patients in intensive care units. Material and Method: The study had a retrospective study design and was conducted among COVID-19 patients followed in the tertiary intensive care units of a training and research hospital. COVID-19 patients, who were older than eighteen years, and intubated in the tertiary intensive care units between March 2020 and January 1, 2021, were included in the present study. Microbiological data such as reproductions in endotracheal aspirate cultures, infectious microorganisms, and antibiotic susceptibility were collected from the patient files. Univariate and Multivariate Binary Logistic Regression analysis were used to determine the risk factors effective in ventilator-associated pneumonia. Results: Ventilator-associated pneumonia was observed in 52.9% (108) of patients, which was confirmed by growth in endotracheal aspirate cultures. The hospitalization (17.56±14.09) and intubated follow-up times (14.55±11.66)(day) of the patients who had culture growth were significantly higher than the hospitalization (9.74±6.01) and intubated follow-up (7.12±4.32)(day) times of the patients without growth (P

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Ventilator-Associated Pneumonia Among Patients With Covid-19: A Systematic Review

Bartoszewicz,

Nadolny

et al. 2023

Emerg Med Serv

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The aim of this study is to investigate the characteristics, epidemiology, and the diagnostic criteria for VAP used most often among patients with COVID-19. PubMed, Embase, Scopus, and Google Scholar were searched between December 2019 and 1 July 2023 with the keywords ventilator-associated pneumonia, COVID-19, VAP, VAP in COVID-19, pneumonia, coronavirus, and SARS-CoV-2. Retrospective and prospective studies, case reports, and randomized controlled trial (RCT) of adults with conf i rmed cases of COVID-19 and VAP were selected for further analysis. Sixty-nine studies with 21,627 patients were included. The occurrence of VAP with COVID-19 ranged from 6%–91%; the mortality of patients with VAP with COVID-19 was 0%–100%. The dif f erence between the ranges is wide owing to dif f erences in study settings and VAP diagnostic criteria used. The bacterial strains responsible for infection were Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Enterobacter species, and Staphylococcus aureus. The percentage of pneumonia associated with multidrug-resistant bacteria varied from 4% to 76%. Most studies were conducted in Europe. The diagnostic criterion used for VAP most often was that of the European Centre for Disease Prevention and Control. CTo reduce the incidence and mortality of VAP, it is crucial to create new empiric antibiotic therapy guidelines and place a focus on adopting VAP prophylaxis in the intensive care unit.

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Evaluation of Microorganisms Isolated from Endotracheal Aspirate Cultures in Patients with and without COVID-19 in the Intensive Care Unit: Single-Centre Retrospective Analysis

Cited by 3 publications

References 0 publications

Ventilator associated pneumonia in COVID-19 patients: A retrospective cohort study

Ventilator associated pneumonia in COVID-19 patients: A retrospective cohort study

Evaluation of Ventilator-Associated Pneumonia Risk Factors and Pathogens in COVID-19 Patients: A Retrospective Study

Ventilator-Associated Pneumonia Among Patients With Covid-19: A Systematic Review

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