Evaluation of midkine expression in dentigerous cysts, odontogenic keratocysts and different types of ameloblastoma

Can, Nuray; Tastekin, Ebru; Yalta, Tülin; Süt, Necdet; Korkmaz, Selma; Usta, Ufuk; Puyan, Fulya Öz; Cezik, Mert; Tutuğ, Busem Binboğa; Köstek, Osman; Tozkır, Hilmi

doi:10.5146/tjpath.2017.01421

Cited by 3 publications

(1 citation statement)

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“…Normal samples were stained with the same amount of antibody used for staining the tumoral tissues. Omission of the primary antibody was employed as negative control, while gastric epithelium was used as positive control for GPC3 11 stages collected by the American Joint Committee on Cancer (AJCC) TNM stage. 12 Tumor grade in ADCC, grade I is referred to as a tubular growth pattern, grade II as a cribriform growth pattern, and grade III as a solid growth pattern.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Glypican-3 expression in benign and malignant salivary gland tumors

Andisheh-Tadbir

Ashraf

Gudarzi

et al. 2019

Journal of Oral Biology and Craniofacial Research

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Introduction: Glypican-3 (GPC3) is involved in regulation of cell proliferation and morphogenesis. It is abundant in embryonic tissue, but limited in most adult tissues. GPC3 deletion or mutation can disturb the balance between cell apoptosis and proliferation, which may result in tumorigenesis. This study aimed to investigate the GPC3 expression in salivary gland tumors (SGTs) and the adjacent non-neoplastic tissues. Methods: This study reviewed 50 samples of salivary tumors from the archive of Khalili Hospital, Shiraz, Iran, including 17 cases of pleomorphic adenoma (PA), 16 cases of mucoepidermoid carcinoma (MEC), and 17 cases of adenoid cystic carcinoma (ACC); as well as a control group of 23 cases of normal salivary gland tissues. GPC3 expression was investigated through immunohistochemistry. Results: GPC3 expression was significantly higher in malignant tumors (MEC and ACC) than in PA, and higher in PA than in the normal salivary glands (P < 0.001). The expression intensity was moderate to strong in malignant tumors and weak to moderate in benign tumors. No strong positivity was observed in normal salivary gland tissues (P < 0.001). Nor was any association detected between the GPC3 expression and intensity with the clinicopathologic parameters. Conclusion: Although GPC3 overexpression was observed at the protein level in SGTs, and its expression was not related with the clinicopathologic factors, the potential use of GPC3 for diagnostic, therapeutic, and prognostic purposes requires further investigations.

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Section: Methodsmentioning

confidence: 99%

Evaluation of Glypican-3 expression in benign and malignant salivary gland tumors

Andisheh-Tadbir

Ashraf

Gudarzi

et al. 2019

Journal of Oral Biology and Craniofacial Research

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Evaluation of serum midkine and carcinoembryonic antigen as diagnostic biomarkers for rectal cancer and synchronous metastasis

Ji¹,

Gu²,

Wang³

2020

Transl Cancer Res TCR

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Methods S-MK and CEA, related to cancer status, were measured in 106 patients and 30 controls by ELISAs. Diagnostic and Prognostic values of S-MK and CEA for rectal cancer were conducted by receiver operating characteristic (ROC) curves with the analysis of sensitivity, specificity, diagnostic accuracy, positive predictive value (PPV) and negative predictive value (NPV) for differential diagnosis. Results Pre-surgical S-MK was elevated in cancer patients than the normal and benign subjects. In term of phases, S-MK and CEA of T3/T4 were both significantly higher than those in T1/T2, with further up-regulation of S-MK. The diagnostic capability of S-MK was higher than CEA and increased in integrating S-MK with CEA when differentiated rectal cancer, benign rectal polyps and normal subjects. Moreover, when evaluating metastasis predictive efficacies, the combination of S-MK and CEA showed higher accuracy than any individual parameter. Conclusions Pre-surgical S-MK is a rectal cancer indicator which is superior to CEA. It can potentially be used to monitor the prognosis of rectal cancer, and predict synchronous metastases, providing assistance to clinicians.

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Current Controversies and Challenges on BRAF V600K-Mutant Cutaneous Melanoma

Nepote

Avallone

Ribero

et al. 2022

JCM

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About 50% of melanomas harbour a BRAF mutation. Of these 50%, 10% have a V600K mutation. Although it is the second most common driver mutation after V600E, no specific studies have been conducted to identify a clinical and therapeutic gold standard for this patient subgroup. We analysed articles, including registrative clinical trials, to identify common clinical and biological traits of the V600K melanoma population, including different adopted therapeutic strategies. Melanoma V600K seems to be more frequent in Caucasian, male and elderly populations with a history of chronic sun damage and exposure. Prognosis is poor and no specific prognostic factor has been identified. Recent findings have underlined how melanoma V600K seems to be less dependent on the ERK/MAPK pathway, with a higher expression of PI3KB and a strong inhibition of multiple antiapoptotic pathways. Both target therapy with BRAF inhibitors + MEK inhibitors and immunotherapy with anti-checkpoint blockades are effective in melanoma V600K, although no sufficient evidence can currently support a formal recommendation for first line treatment choice in IIIC unresectable/IV stage patients. Still, melanoma V600K represents an unmet medical need and a marker of poor prognosis for cutaneous melanoma.

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Evaluation of midkine expression in dentigerous cysts, odontogenic keratocysts and different types of ameloblastoma

Cited by 3 publications

References 20 publications

Evaluation of Glypican-3 expression in benign and malignant salivary gland tumors

Evaluation of Glypican-3 expression in benign and malignant salivary gland tumors

Evaluation of serum midkine and carcinoembryonic antigen as diagnostic biomarkers for rectal cancer and synchronous metastasis

Current Controversies and Challenges on BRAF V600K-Mutant Cutaneous Melanoma

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