Wheat (Triticum aestivum L.)–cotton (Gossypium hirsutum L.) relay strip intercropping involves cultivating wheat sown in autumn and cotton sown in spring, allowing the two crops to grow together for ∼2 months. Despite its prevalence in cotton‐growing regions globally, this agricultural practice remains untapped in Turkey, where the emphasis on resource use efficiency and the competition between staple and cash crops are paramount. To address this, we conducted a study comparing three cropping systems under both well‐watered and limited water conditions: sole wheat with a row spacing of 13.5 cm, sole cotton with a row spacing of 70 cm, and an intercropping system consisting of four rows of wheat and two rows of cotton, with row spacings of 13.5 cm and 40.5 cm, respectively. In intercropped wheat and cotton, the relative wheat yield was 0.68, while the relative cotton yield was 0.73, resulting in a combined relative yield of 1.41 when compared to monoculture. The land equivalent ratio (1.44) and area time equivalent ratio (1.08) consistently exceeded 1.0, particularly under limited watering conditions and concurrent heat stress observed in the second year of the experiment. Our findings indicate that wheat–cotton relay intercropping holds significant potential as a highly effective approach to enhance the production of both cotton and wheat in Turkey, particularly in stressful conditions such as limited water availability.