Evaluation of monomer leaching from a dual cured resin cement

Abstract

In the case of resin cement, leaching of TEGDMA was the highest and the cumulative amount of leaching monomers from resin cement was influenced by the time.

Evaluation of residual monomer release and toxicity of self-adhesive resin cements

“…Resin-based materials are known to show toxic reactions in cell cultures and various studies have shown that toxicity is primarily induced by monomers released from the material 3,6,12,13,[18][19][20] . In this study, the elution of UDMA and TEGDMA from self-adhesive resin cements in artificial saliva with time is evaluated and biological effects of the cumulative monomer amounts are determined.…”

“…Ideally, a dental resin should have all monomers converted to polymers during the polymerization reaction. Dual-cure materials tend to be more effective in the early stages of polymerization because they contain both photo initiators and components for a chemically activated reaction 19) . Kawahara et al 7) used HPLC to investigate the elution of residual monomers at 1, 3, 6, 12, and 24 h and 3, 7, and 14 days.…”

“…Crosslinked dimethacrylate resins are virtually insoluble but are capable of swelling in good solvents 18,22) . The degradation of resins in the oral cavity depends on salivary enzymatic reactions, acidic conditions and erosive factors caused by food and drinks 23) ; therefore, organic solvents such as ethanol, methanol, or mixtures of these solvents with water are especially preferred when simulating oral conditions 18,22) .…”

“…The degradation of resins in the oral cavity depends on salivary enzymatic reactions, acidic conditions and erosive factors caused by food and drinks 23) ; therefore, organic solvents such as ethanol, methanol, or mixtures of these solvents with water are especially preferred when simulating oral conditions 18,22) . Organic solvents have the ability to penetrate and swell the polymer network, facilitating the liberation of unreacted and leachable monomers.…”

“…Penetration of the solvent into the matrix and the resultant expansion of the openings between polymer chains cause oligomers to diffuse out 22) . The intraoral fluids represent solvents with characteristics probably somewhere between the more aggressive organic solvents and water; the US FDA recommends using a 75% ethanol-water solution as a food/oral simulating liquid with clinical relevance 18,24) . However, the use of an ethanol/water immersion has been abandoned, as this would lead to the expansion of the polymer network and an excessive diffusion of residual monomers 24) .…”