Evaluation of Mucosal Healing of Ulcerative Colitis by a Quantitative Fecal Immunochemical Test

Fecal Hemoglobin and Calprotectin Are Equally Effective in Identifying Patients with Inflammatory Bowel Disease with Active Endoscopic Inflammation

“…One previous study investigated fecal hemoglobin as a marker for inflammation in 152 patients with UC. 8 Fecal hemoglobin was assessed using a quantitative fecal immunochemical test, which is commonly used in sporadic colorectal cancer screening programs. 18 The authors found that levels above a cutoff of 100 ng/mL indicated endoscopic inflammation ).…”

“…One previous study in patients with UC indeed showed that the concentration of fecal hemoglobin correlated well with the endoscopic severity of inflammation. 8 Whether fecal hemoglobin is inferior or superior to calprotectin in identifying patients with mucosal inflammation is currently unknown. Therefore, the aim of this study was to compare the performance of fecal hemoglobin and calprotectin as markers for the presence of endoscopic inflammation in patients with CD and UC.…”

Biomarkers of Inflammatory Bowel Disease

“…A study consists of 152 UC demonstrates that the sensitivity and specificity of FIT could reach up to 92% and 71% when cutoff <100 ng/mL; FIT also correlated with Mayo scores [106]. …”

Role of Biomarkers in the Study and Management of Inflammatory Bowel Disease

“…69 Much more recently, Japanese investigators have studied fecal immunochemical testing as an assay of mucosal healing in UC. 70 Canadian researchers this year have also reviewed in considerable detail the clinical utility of a range of fecal biomarkers, including calprotectin, lactoferrin, S100A12, pyruvate kinase, and matrix metalloproteinases. 71 By far the 2 most widely studied fecal markers of inflammation, however, are calprotectin and lactoferrin.…”