Evaluation of Multiple Organ Dysfunction Score (MODS) and the Sequential Organ Failure Assessment (SOFA) score as in-hospital outcome predictors among cases of hydrogen cyanamide exposure: a cross-sectional study

Sharif, Asmaa F; Fayed, Manar Maher

doi:10.1007/s11356-021-13655-6

Cited by 14 publications

(10 citation statements)

References 32 publications

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“…This increase in urea and creatinine induced by dormex comes in accordance with results of El Masry et al, (2000) . In previous clinical research on patients acutely intoxicated with dormex, evident nephrotoxicity was reported manifested by increase serum creatinine and blood urea level (Gamaluddin et al, 2012;Sharif and Fayed, 2021). Makris and Spanou, (2016) allocated that increased serum creatinine indicates renal injury and even at certain levels renal failure.…”

Section: Discussionmentioning

confidence: 99%

“…Group III: 10 rats received a single oral administration of dormex (100 mg/kg body weight suspended in 1 mL saline) (1/3 LD50) (Meister, 1994;El Masry et al, 2000) via an oral cannula at the end of the 4th day. Dormex is well known to cause local corrosive effect on tissues it comes in contact with (Sharif and Fayed, 2021). Rats were treated by intra-peritoneal injection of 25mg/kg of acetaminophen in a volume of 10 mg/ml (Acetaminophen, Perfalgan®, BMS Pharmaceutical, Italy) to overcome pain (Im et al, 2012).…”

Section: Experimental Designmentioning

confidence: 99%

“…Dormex is reported to cause serious clinical manifestations as headache, hypotension, palpitation, respiratory distress, vomiting, disulfiram-like reaction in addition to skin and ocular irritation (Sharif and Fayed, 2021). Marked hepatotoxic effect of acute dormex exposure has been reported in many patients with noticeable elevation of liver enzymes together with affection of other liver function as PT and bilirubin level.…”

mentioning

confidence: 99%

“…Marked hepatotoxic effect of acute dormex exposure has been reported in many patients with noticeable elevation of liver enzymes together with affection of other liver function as PT and bilirubin level. Considerable elevation of serum creatinine has been recorded in some patients with acute hydrogen cyanamide poisoning (Gamaluddin et al, 2012;El Mahdy and Kharoub, 2020;Sharif and Fayed, 2021). The main mechanism of nephrotoxicity of dormex is not yet known.…”

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confidence: 99%

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Nephrotoxic effect of Hydrogen Cyanamide (Dormex) and possible protective role of N-acetyl cysteine in male albino rats

Elbastawesy

Ibrahim

Safia

et al. 2022

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background: Dormex is a highly toxic fertilizer that causes local tissue irritation in addition to multiple organ toxicity mainly through oxidative stress. Aim of the study: This study aimed to investigate nephrotoxic effect of dormex and to evaluate potential protective role of N-acetyl cysteine (NAC) on kidney of male albino rats. Methods: This study was conducted on forty mature male albino rats were distributed to; Group I, II: rats were given normal saline and NAC, respectively. Group III: rats received single dose of dormex. Group IV: rats were given the same dose of dormex plus NAC. Blood urea and serum creatinine were assessed. Oxidative stress markers as malondialdehyde (MDA), catalase, reduced glutathione and superoxide dismutase (SOD ) were measured. Renal specimens were studied with hematoxylin and eosin. Results: Renal indices, urea and creatinine, MDA were significantly increased, while glutathione reductase, catalase and glutathione peroxidase were lowered significantly in experimental rats received dormex. Kidney tissue of dormex administered rat's revealed tubulointerstitial nephritis, tubular necrosis and obstruction. Treatment with NAC markedly improved oxidative stress parameters but did not show marked effect on dormex induced histopathological changes. Conclusions: It can be concluded that dormex triggers oxidative stress causing affection of the renal function. Although NAC could decrease oxidative stress, it was not able to protect against cellular toxicity of dormex.

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Section: Discussionmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Nephrotoxic effect of Hydrogen Cyanamide (Dormex) and possible protective role of N-acetyl cysteine in male albino rats

Elbastawesy

Ibrahim

Safia

et al. 2022

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…Additionally, HC reagents are highly phytotoxic and can cause bud damage ( Or et al., 1999 ). High temperatures can also exacerbate its harmful effects on buds, and toxic exposure is particularly concerning when HC is applied during summer practices ( Sharif and Fayed, 2021 ). Therefore, studying the mechanism of paradormancy release induced by HC can be beneficial for facilitating the search for low-toxicity and high-efficiency alternatives and improving cultivation techniques.…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptome analysis of genes involved in paradormant bud release response in ‘Summer Black’ grape

Fan,

Luo,

Wang

et al. 2023

Front. Plant Sci.

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Grapevines possess a hierarchy of buds, and the fruitful winter bud forms the foundation of the two-crop-a-year cultivation system, yielding biannual harvests. Throughout its developmental stages, the winter bud sequentially undergoes paradormancy, endodormancy, and ecodormancy to ensure survival in challenging environmental conditions. Releasing the endodormancy of winter bud results in the first crop yield, while breaking the paradormancy of winter bud allows for the second crop harvest. Hydrogen cyanamide serves as an agent to break endodormancy, which counteracting the inhibitory effects of ABA, while H2O2 and ethylene function as signaling molecules in the process of endodormancy release. In the context of breaking paradormancy, common agronomic practices include short pruning and hydrogen cyanamide treatment. However, the mechanism of hydrogen cyanamide contributes to this process remains unknown. This study confirms that hydrogen cyanamide treatment significantly improved both the speed and uniformity of bud sprouting, while short pruning proved to be an effective method for releasing paradormancy until August. This observation highlights the role of apical dominance as a primary inhibitory factor in suppressing the sprouting of paradormant winter bud. Comparative transcriptome analysis revealed that the sixth node winter bud convert to apical tissue following short pruning and established a polar auxin transport canal through the upregulated expression of VvPIN3 and VvTIR1. Moreover, short pruning induced the generation of reactive oxygen species, and wounding, ethylene, and H2O2 collectively acted as stimulating signals and amplified effects through the MAPK cascade. In contrast, hydrogen cyanamide treatment directly disrupted mitochondrial function, resulting in ROS production and an extended efficacy of the growth hormone signaling pathway induction.

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Comparison between various scoring systems in predicting the need for intensive care unit admission of acute pesticide-poisoned patients

El-Sarnagawy

Abdelnoor

Abuelfadl

et al. 2022

Environ Sci Pollut Res

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Evaluation of Multiple Organ Dysfunction Score (MODS) and the Sequential Organ Failure Assessment (SOFA) score as in-hospital outcome predictors among cases of hydrogen cyanamide exposure: a cross-sectional study

Cited by 14 publications

References 32 publications

Nephrotoxic effect of Hydrogen Cyanamide (Dormex) and possible protective role of N-acetyl cysteine in male albino rats

Nephrotoxic effect of Hydrogen Cyanamide (Dormex) and possible protective role of N-acetyl cysteine in male albino rats

Comparative transcriptome analysis of genes involved in paradormant bud release response in ‘Summer Black’ grape

Comparison between various scoring systems in predicting the need for intensive care unit admission of acute pesticide-poisoned patients

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