Background: Musculoskeletal conditions are a frequent reason for seeking medical attention. In the United States and Canada, orthopedic injuries constitute about 15-30% of primary care visits. Physicians from various specialties encounter musculoskeletal conditions and manage both, acute and chronic problems, on a daily basis. Considering this, mastery of the fundamentals of musculoskeletal medicine is required for all medical school graduates. In this study, we aim to evaluate the attitudes and knowledge of musculoskeletal medicine among medical students at King Faisal University. Methodology: A cross-sectional study with one-stage sampling technique was conducted among medical students at King Faisal University from February 2021 to May 2021. Results: Our study demonstrated that students possess a lower level of clinical confidence in their ability to perform musculoskeletal clinical examinations compared to pulmonary clinical examinations. Further, they displayed a lower level of clinical confidence in their ability to make musculoskeletal differential diagnoses compared to pulmonary differential diagnoses. Also, their average scores on the basic competency exam did not reach 73.1. Conclusion: The current study evaluated the attitudes and knowledge of musculoskeletal medicine among medical students at King Faisal University. The findings in our study are consistent with the results of other research that indicate medical students are not getting sufficient education in musculoskeletal medicine.