Evaluation of Mutagenic Profile of Shrimp Paste Extracts by Using Ames Test

Mohammad, Nur Hafiza; Yusoff, Nurlaily Ezzaty Moha; Zulfakar, Siti Shahara; Sharif, Razinah

doi:10.3923/pjn.2016.170.175

Cited by 2 publications

(1 citation statement)

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“…It was postulated that salt can help in the nitrosation process and may produce dangerous oncometabolites, as well as being involved in promoting Epstein Barr virus, which is a common feature in those with NPC. In an in vitro toxicity model, salt and nitroso compounds were identified as inducers of mutagenicity and genome damage [ 60 – 61 ]. The cancer incidence also may be related to the genetic polymorphism, Epstein-Barr virus and many other confounding factors that should be included in the risk factors by using the exposome model framework which warrants further investigation in this area of research.…”

Section: Main Textmentioning

confidence: 99%

Understanding exposomes and its relation with cancer risk in Malaysia based on epidemiological evidence: a narrative review

Sharif,

Ooi

2024

Genes and Environ

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The prevalence of cancer is increasing globally, and Malaysia is no exception. The exposome represents a paradigm shift in cancer research, emphasizing the importance of a holistic approach that considers the cumulative effect of diverse exposures encountered throughout life. The exposures include dietary factors, air and water pollutants, occupational hazards, lifestyle choices, infectious agents and social determinants of health. The exposome concept acknowledges that each individual’s cancer risk is shaped by not only their genetic makeup but also their unique life experiences and environmental interactions. This comprehensive review was conducted by systematically searching scientific databases such as PubMed, Scopus and Google Scholar, by using the keywords “exposomes (environmental exposures AND/OR physical exposures AND/OR chemical exposures) AND cancer risk AND Malaysia”, for relevant articles published between 2010 and 2023. Articles addressing the relationship between exposomes and cancer risk in the Malaysian population were critically evaluated and summarized. This review aims to provide an update on the epidemiological evidence linking exposomes with cancer risk in Malaysia. This review will provide an update for current findings and research in Malaysia related to identified exposomes-omics interaction and gap in research area related to the subject matter. Understanding the interplay between complex exposomes and carcinogenesis holds the potential to unveil novel preventive strategies that may be beneficial for public health.

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Section: Main Textmentioning

confidence: 99%