Evaluation of mycotoxins and their metabolites in human breast milk using liquid chromatography coupled to high resolution mass spectrometry

Rubert, Josep; León, Núria; Sáez, Carmen Martínez; Martins, Cláudia P.B.; Godula, Michal; Yusà, Vicent; Mañes, Jordi; Castillo, José Miguel Soriano del; Soler, Carla

doi:10.1016/j.aca.2014.02.009

Cited by 91 publications

(69 citation statements)

References 35 publications

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“…Multi-mycotoxin analysis in beer-based drinks by a modified QuEChERS method and UHPLC-MS/MS was conducted by Tamura et al [78]. Evaluation of mycotoxins and their metabolites in human breast milk by a newly developed method based on QuEChERS extraction and UHPLC-HRMS detection was carried out by Rubert et al [79]. Frenich et al described a QuEChERS-based extraction procedure for multi-mycotoxin analysis in eggs [80].…”

Section: Mycotoxins Analysismentioning

confidence: 99%

A review of recent developments and trends in the QuEChERS sample preparation approach

2015

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Abstract:A comprehensive review is presented on the recent developments and trends in the QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample preparation approach. This technique involves liquidliquid partitioning using acetonitrile and purifying the extract using dispersive solid-phase extraction (d-SPE). Originally, the QuEChERS was introduced for pesticides residues analysis in high moisture fruits and vegetables, but more recently it is gaining significant popularity in the analysis of broad spectrum of analytes in huge variety of samples. The wide range of the technique applications is possible due to introducing various modifications based on the use of different extraction solvent and salt formulation and buffer additions for salting-out partitioning step and the application of various d-SPE sorbents for clean-up step. Therefore, the QuEChERS approach is useful for analysis of, among others pesticides, veterinary drugs and other pharmaceuticals, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), dyes, acrylamide, synthetic musks and UV filters, bisphenols, polybrominated diphenyl ethers and other flame retardants, endocrine disruptors, and other chemical compounds. Thanks to the QuEChERS approach, high-throughput multiresidue methods operate in a routine contaminant control of food products, feedstuff, and environmental samples.

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Section: Mycotoxins Analysismentioning

confidence: 99%

A review of recent developments and trends in the QuEChERS sample preparation approach

2015

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“…The evaporation process was timeconsuming because a yellow viscous pellet, containing undetermined components 13 extracted from milk, appeared in the tube preventing complete dryness and adequate resuspension. In order to obtain a clean dry extract, and based on reference literature [38], the addition of certain salts during the extraction procedure, such as NaCl and …”

Section: Extraction Proceduresmentioning

confidence: 99%

Development and validation of a high performance liquid chromatographic–mass spectrometry method for the simultaneous quantification of 10 trichothecenes in ultra-high temperature processed cow milk

Flores-Flores

González-Peñas

2015

Journal of Chromatography A

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“…In the GI tract they included abdominal pain, diarrhoea, blood in the stool, and vomiting), but the most frequent were irritated throat and secondary infections of the upper respiratory tract. Except for the study by Rubert et al (97) there are no other reports of NIV and HT-2 toxin contamination of breast milk.…”

Section: Nd-not Detectedmentioning

confidence: 77%

“…In a recent Spanish study (97), ZEA was found in 13 out of 35 samples of human breast milk (37 %) and its metabolites α-ZAL and β-ZAL in only one sample (2 %).…”

Section: Zearalenonementioning

confidence: 99%

Mycotoxicoses in children

Peraica

Richter

Rašić

2014

Archives of Industrial Hygiene and Toxicology

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Mycotoxicoses are acute and chronic poisonings caused by mould toxins called mycotoxins. Although acute mycotoxicoses, caused by high mycotoxin levels in food are rare nowadays, they need to be described in order to inform physicians and other health care workers about their symptoms. Children are more sensitive to mycotoxins because of their lower body mass, higher metabolic rate, and underdeveloped organ functions and detoxication mechanisms. Some mycotoxicoses appear only in children, and some are more pronounced in children than in adults. Acute mycotoxicoses in children are reported poorly, mostly because they occur in the tropical regions with poor healthcare coverage. In developed countries healthcare authorities are more concerned about child exposure to low levels of mycotoxins with immunotoxic, genotoxic or carcinogenic properties.

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Evaluation of mycotoxins and their metabolites in human breast milk using liquid chromatography coupled to high resolution mass spectrometry

Cited by 91 publications

References 35 publications

A review of recent developments and trends in the QuEChERS sample preparation approach

A review of recent developments and trends in the QuEChERS sample preparation approach

Development and validation of a high performance liquid chromatographic–mass spectrometry method for the simultaneous quantification of 10 trichothecenes in ultra-high temperature processed cow milk

Mycotoxicoses in children

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