Evaluation of myocardial function in neonatal sepsis using tissue Doppler imaging

Fahmey, Sameh Samir; Hodeib, Mahmoud; Refaat, Khaled; Mohammed, Walaa

doi:10.1080/14767058.2019.1583739

Cited by 10 publications

(9 citation statements)

References 25 publications

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“…Various observational studies have assessed the haemodynamic response to LOS but few provided descriptive evidence of the haemodynamic presentation, clinical course of EOS and the progression to septic shock in this vulnerable age group 5–10,13–15 . Our clinical and ultrasound observational data revealed that preterm infants with EOS presented with either normal clinical findings and haemodynamic cardiac ultrasound parameters within the reference range, or with hypotension and higher as expected blood flows suggestive of warm shock.…”

Section: Discussionmentioning

confidence: 74%

“…The cardiovascular transition from fetus to newborn is a complex haemodynamic situation where many changes in lung compliance, cardiac function and vascular tone are expected. There is limited data on the clinical and haemodynamic presentation of EOS in newborns, especially for preterm infants 5,6 . In studies of preterm neonates with late‐onset sepsis (LOS), the predominant haemodynamic presentation was high cardiac output and low systemic vascular resistance 7,8 .…”

Section: What Is Already Known On This Topicmentioning

confidence: 99%

“…There is limited data on the clinical and haemodynamic presentation of EOS in newborns, especially for preterm infants. 5 , 6 In studies of preterm neonates with late‐onset sepsis (LOS), the predominant haemodynamic presentation was high cardiac output and low systemic vascular resistance. 7 , 8 Our hypothesis was that preterm infants with EOS would behave similarly.…”

mentioning

confidence: 99%

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Clinical and haemodynamic characteristics of preterm infants with early onset sepsis

Johnston

Waal

2022

J Paediatrics Child Health

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Aim: Early onset sepsis (EOS) in preterm infants is associated with high morbidity and mortality. Improved characterisation of the haemodynamic presentation of EOS could lead to more effective and targeted treatments. Methods: We performed a retrospective observational study of preterm infants ≤32 week' gestation with EOS between 2010 and 2020 and gathered clinical, haemodynamic and echocardiographic data. Results: Of the 2198 admitted infants, 27 infants (median gestational age 28 weeks, median birthweight 1174 g) developed EOS with predominantly gram-negative pathogens and the overall mortality rate was 33.3%. Besides hypotension, clinical signs were non-specific, and over half of infants were normotensive in the first 72 h of life. Those with hypotension received more fluid resuscitation, inotropic support and had a higher mortality compared to the normotensive infants. Cardiac ultrasound was available in 18 infants and commonly revealed higher as expected cardiac output, pulmonary hypertension and diastolic dysfunction. Conclusion: Preterm infants with EOS had a high mortality rate, especially when they progressed from sepsis to septic shock. Echocardiography revealed a normal haemodynamic pattern, or one suggestive of vasodilatation and warm shock physiology. Targeting this pathophysiology earlier might improve outcomes.

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Section: Discussionmentioning

confidence: 74%

Section: What Is Already Known On This Topicmentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical and haemodynamic characteristics of preterm infants with early onset sepsis

Johnston

Waal

2022

J Paediatrics Child Health

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“…This is consistent with the Alazharani's stud (27) . On the other hand, Fahmey et al found no difference in FS% between the septic neonates and their control group (18) . Furthermore, the LV's ejection fraction EF% which measures its systolic function, was lower in septic than aseptic neonates.…”

Section: Regardingmentioning

confidence: 93%

“…and tricuspid valvular incompetence were detected to be present or not by using the Color Doppler Echocardiography (18) .…”

Section: Mitralmentioning

confidence: 99%

Role of Serum Copeptin and Ischemia-modified Albumin in Detection of Cardiac Affection in Neonatal Sepsis

El sayed,

Hegazy,

Habeed

et al. 2024

Ain Shams Medical Journal

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Background: Neonatal sepsis is a serious condition with increased morbidity and mortality. Cardiac complications are common sequalae for neonatal sepsis with poor prognosis. Utilization of biomarkers for early detection of these cardiac complications helps in improving the prognosis. Aim of the work: Detect the reliability of plasma copeptin and ischemia-modified albumin (IMA) as indicators of cardiac involvement in neonatal sepsis. Patients and methods:The current study included 70 late preterm neonates divided into 3 groups; 30 neonates diagnosed with sepsis and cardiac affection (group 1), 20 neonates diagnosed with sepsis without cardiac affection (group 2) and 20 matched neonates free of sepsis and cardiac affection (group 3). All included neonates had a full history taking, general and local examination. In addition to measuring serum copeptin and IMA levels. Cardiac functions were assessed by transthoracic echocardiography and tissue doppler imaging.Results: A significantly higher mean value of copeptin in group 1 (12.26 ± 4.06 ng/ml), followed by group 2 (4.25±1.56 ng/ml), then group 3 (2.17±0.79 ng/ml) (p<0.001). Also, IMA was significantly higher in group 1 (263.97±81.49 ng/ml), followed by group 2 (68.62±22.08 ng/ml), then group 3 (35.94±10.94 ng/ml) (p<0.001). There was a significant positive correlation between copeptin with IMA. Conclusion:Serum Copeptin and IMA levels are good predictors for detection of cardiac complications in neonatal sepsis besides their role in sepsis detection itself.

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Cardiovascular Compromise in the Newborn Infant

Noori¹,

Seri²

2024

Avery's Diseases of the Newborn

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Evaluation of myocardial function in neonatal sepsis using tissue Doppler imaging

Cited by 10 publications

References 25 publications

Clinical and haemodynamic characteristics of preterm infants with early onset sepsis

Clinical and haemodynamic characteristics of preterm infants with early onset sepsis

Role of Serum Copeptin and Ischemia-modified Albumin in Detection of Cardiac Affection in Neonatal Sepsis

Cardiovascular Compromise in the Newborn Infant

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