Evaluation of Myocardial Strain in Patients With Amyloidosis Using Cardiac Magnetic Resonance Feature Tracking

Pandey, Tarun; Alapati, Sindhura; Wadhwa, Vibhor; Edupuganti, Mohan Mallikarjuna Rao; Gurram, Pooja; Lensing, Shelly; Jambhekar, Kedar

doi:10.1067/j.cpradiol.2016.11.008

Cited by 20 publications

(25 citation statements)

References 20 publications

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“…To our knowledge, this is the first study to show MRI FT strain provides prognostic information in AL amyloidosis. To date, MRI FT strain has been used in diagnosis of AL amyloid, by showing that patients with biopsy proven cardiac amyloidosis have decreased strain compared to normal controls [18,19]. However, our study is the first to show that MRI FT strain provides prognostic information in AL amyloidosis.…”

Section: Discussionmentioning

confidence: 72%

MRI feature tracking strain is prognostic for all-cause mortality in AL amyloidosis

Illman

Arunachalam

Arani

et al. 2018

Amyloid

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Section: Discussionmentioning

confidence: 72%

MRI feature tracking strain is prognostic for all-cause mortality in AL amyloidosis

Illman

Arunachalam

Arani

et al. 2018

Amyloid

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“…Basal RS was significantly reduced in patients with CA, resulting in higher basoapical RS gradients. Apical sparing might be preserved in early stage CA, with gradients diminishing with advanced disease (11). LS is impaired at the early stage of most diseases as an early marker of cardiac dysfunction (28).…”

Section: Discussionmentioning

confidence: 99%

“…Based on the characteristic apical sparing of CA, an STE strain gradient yielded a sensitivity of 83% for diagnosing both CA and HCM (7). CMR-tissue tracking (CMR-TT) is a technique comparable to STE and apical sparing of CA occurs on this method (10)(11)(12). Therefore, we hypothesized that CA could be distinguished from HCM using CMR-TT without gadolinium.…”

Section: Introductionmentioning

confidence: 99%

Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy

et al. 2019

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Background Administration of gadolinium-contrast can cause problems in cardiac amyloidosis (CA) patients with impaired renal function. Purpose To compare patterns of cardiovascular magnetic resonance tissue tracking (CMR-TT) for CA and hypertrophic cardiomyopathy (HCM) and to assess the feasibility of CMR-TT to distinguish between these diseases without administration of gadolinium-contrast. Material and Methods Included were 54 patients with biopsy-proven CA, 40 patients with HCM, and 30 healthy people. We calculated strain ratio of apex to base (SRAB) in the left ventricle (LV) using radial (R), circumferential (C), and longitudinal (L) strain from CMR-TT. The LV ejection fraction (LVEF) and the ratio of septal to posterior wall at basal level were also calculated. Late gadolinium enhancement (LGE) image analysis was performed for differential diagnosis. Area under the receiver operating characteristic curve (AUC) comparisons were used. Results All SRAB values were significantly different between CA and HCM (all P < 0.001). AUC values for parameters were 0.806 for LVEF, 0.815 for ratio of wall thickness, 0.944 for the LGE pattern, 0.898 for SRABR, 0.880 for SRABC, and 0.805 for SRABL. AUCs for the LGE pattern were significantly higher than for LVEF, ratio of wall thickness and SRABL (all P < 0.008). No significant differences were seen between AUCs for the LGE pattern, SRABR, and SRABC (all P > 0.109). Conclusion SRABR and SRABC were reliable parameters for distinguishing between CA and HCM.

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“…Cardiac magnetic resonance (CMR) imaging is the established reference standard for the quantification of LV size and function. CMR-derived strain measured by feature tracking has been used as a reference technique in several recent studies [12][13][14][15][16][17][18][19][20]. However, the availability of CMR is limited, and until recently, no commercial STE software has been able to measure strain from contrast-enhanced echocardiographic images.…”

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced echocardiographic measurement of longitudinal strain: accuracy and its relationship with image quality

Karagodin

Genovese

Kruse

et al. 2019

Int J Cardiovasc Imaging

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The importance of left ventricular (LV) global longitudinal strain (GLS) is increasingly recognized in multiple clinical scenarios. However, in patients with poor image quality, strain is difficult or impossible to measure without contrast enhancement. The feasibility of contrast-enhanced GLS measurement was recently demonstrated. We sought to determine: (1) whether contrast enhancement improves the accuracy of GLS measurements against cardiac magnetic resonance (CMR) reference, (2) their reproducibility compared to non-enhanced GLS, and (3) the dependence of accuracy and reproducibility on image quality. We prospectively enrolled 25 patients undergoing clinically indicated CMR imaging who subsequently underwent transthoracic echocardiography (TTE) with and without low-dose contrast injection (1-2 mL Optison/3-5 mL saline IV, GE Healthcare). GLS was measured from both non-contrast and contrast-enhanced images using speckle tracking (EchoInsight, Epsilon Imaging). These measurements were compared to each other and to CMR reference values obtained using feature tracking (SuiteHEART, NeoSoft). Inter-technique comparisons included linear regression and Bland-Altman analyses. A random subgroup of 15 patients was used to assess inter-and intra-observer variability using intra-class correlation (ICC). Contrast-enhanced GLS was in close agreement with non-enhanced GLS (r = 0.95; bias: − 0.2 ± 1.5%). Both inter-observer (ICC = 0.88 vs. 0.82) and intra-observer variability (ICC = 0.91 vs. 0.88) were improved by contrast enhancement. The agreement with CMR was better for contrast-enhanced GLS (r = 0.87; bias: 1.1 ± 2.2%) than for non-enhanced GLS (r = 0.80; bias: 1.3 ± 2.7%). In 12/25 patients with suboptimal TTE images that rendered GLS difficult to measure, contrast-enhanced GLS showed better agreement with CMR than non-enhanced GLS (r = 0.88 vs. 0.83) and also improved inter-observer (ICC = 0.83 vs. 0.76) and intra-observer variability (ICC = 0.88 vs. 0.82). In conclusion, contrast enhancement of

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Evaluation of Myocardial Strain in Patients With Amyloidosis Using Cardiac Magnetic Resonance Feature Tracking

Cited by 20 publications

References 20 publications

MRI feature tracking strain is prognostic for all-cause mortality in AL amyloidosis

MRI feature tracking strain is prognostic for all-cause mortality in AL amyloidosis

Comparison of tissue tracking assessment by cardiovascular magnetic resonance for cardiac amyloidosis and hypertrophic cardiomyopathy

Contrast-enhanced echocardiographic measurement of longitudinal strain: accuracy and its relationship with image quality

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