Evaluation of N-Butyl 2-Cyanoacrylate for the Fixation of Osteochondral Fractures

Abstract

SummaryUnstable osteochondral fractures were created on one medial femoral condyle of 39 adult rabbits. The fractures were repaired with n-butyl cyanoacrylate adhesive in 21 rabbits. The remaining fractures were not repaired. Radiographs were made at frequent intervals. The rabbits were euthanatized at 4, 6, 8, 12, and 16 weeks after surgery. The alignment and stability of the osteochondral fragments were assessed, followed by collection of sections of the medial femoral condyles for histological evaluation. Radiologically, the adhesive repaired fractures healed by primary bone union. The adhesive repaired fractures were significantly (p <0.05) better aligned and more stable than the non-repaired fractures at necropsy. Histologically, there was healing of the subchondral fracture lines of adhesive repaired fractures. The articular cartilage overlying the healing fragments was normal or had only minor surface irregularities.

Avian Fracture Healing Following Stabilization with Intramedullary Polyglycolic Acid Rods and Cyanoacrylate Adhesive vs. Polypropylene Rods and Polymethylmethacrylate

“…In addition, the presence of longer side chain cyanoacrylates does not appear to interfere with adjacent fracture healing (50,53,54,56,57). Cyanoacrylate stabilization of traumatically induced and osteochondritis dissecans osteochondral fragments from the canine talus and humeral head has been performed with good results (45). Our findings are in good accord with these studies.…”

“…The use of cyanoacrylates to stabilize osteochondral fragments, and osteotomies has also been reported (45,50,53,54,56,57,66). Bone-cyanoacrylate bond strengths increase with increasing side chain length (48,59,67).…”

Uso da cola n-butil cianoacrilato na sulcoplastia de recessão em coelhos: avaliação histológica

“…A boa estabilização da cunha óssea cartilaginosa no grupo controle, em todos os períodos de observação, indicou que a pressão exercida pela patela, como citado por outros autores (ROUSH, 1993;SLOCUM & SLOCUM, 1993;VASSEUR, 1993;SEGUIN & HARARI, 1994), foi suficiente para mantê-la em seu leito. Desta forma, neste modelo experimental não foi possível avaliar o poder de adesão da cola, sendo o mesmo um tanto controverso na dependência da composição do produto e tipo de lesão induzida (LIGHTERMAN & FARRELL, 1962;WEBER & CHAPMAN, 1984;HARPER, 1988;ARON & GORSE, 1991;CAROLI et al, 1997;ARUN, 2002).…”

“…ARON & GORSE (1991) estabilizaram, em seis cães, fragmentos osteocondrais e condrais com n-butil-2-cianocrilato. Exames radiográficos não foram adequados para visibilizar a cicatrização dos fragmentos.…”

Osteochondrosis dissecans of the tarsus in Labrador Retrievers: Clinical signs, radiological data and force plate gait evaluation after surgical treatment

“…Two types of OCD lesions can be identified in the tarsus: a thin flap of cartilage and a sub-stantial piece of cartilage attached to subchondral bone. These large fragments are probably a result of subchondral fractures or bone formation in cartilaginous flaps, which were invaded by a capillary bed originating from synovium, allowing for continued endochondral ossification (3,(6)(7)(8)(9)(10)(11). Removing large osteochondral fragments sometimes leads to severe incongruity and instability of the tarsocrural joint, particularly when the lesion is curetted (1,4,6,(12)(13)(14)(15).…”