Evaluation of natural products as therapeutic alternatives for bovine mastitis and implications for future research

Ucella-Filho, João Gilberto Meza; Ferreira, Nicolly Soares; Alves, Mateus Rodrigues; Ignacchiti, Mariana Drummond Costa; Dias Júnior, Ananias Francisco; Resende, Juliana Alves

doi:10.1016/j.sajb.2024.02.031

Cited by 1 publication

(1 citation statement)

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“…Hence, alternative EO treatment has been assessed in vitro on the major bacterial [21][22][23][24][25][26][27][28] and fungal mastitis pathogens [12,16,29]. Moreover, including Candida in studies investigating natural products for the treatment of bovine mastitis is important to assess their potential efficacy against this fungal pathogen and broaden understanding of therapeutic alternatives for managing mastitis cases caused by diverse microbial agents [30].…”

Section: Introductionmentioning

confidence: 99%

Clinical Evidence on Expansion of Essential Oil-Based Formulation’s Pharmacological Activity in Bovine Mastitis Treatment: Antifungal Potential as Added Value

Tomanić,

Božić,

Kladar

et al. 2024

Antibiotics

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Bovine mastitis, as a significant and prevalent health problem in dairy herds, is primarily attributed to bacterial infections. Yeasts, although considered relatively rare causative agents, have also been associated with mastitis in dairy cattle. Current mastitis treatment predominantly relies on antibiotics, with limited emphasis on antifungal treatment. However, mycotic mastitis is challenging to treat, since these fungi are often resistant to antibiotics and may even utilize them for energy. In the current research, the in vivo antimicrobial activity of the essential oil-based formulation (Phyto-Bomat), as a possible alternative mastitis treatment associated with yeasts, was studied. This study involved a total of 68 animals from two dairy farms with diagnosed mastitis, and three treatment groups were established: conventional antibiotic treatment, Phyto-Bomat treatment, and the combination of both. The findings suggest significant variations in the presence of Candida samples based on the treatment administered, and the most significant difference was noted in cows treated with the combination (Phyto-Bomat and antibiotics). Yet, it is important to note that the results reveal that, regardless of the treatment type, there are statistically significant differences in the presence of Candida samples across the examined time points. These results aim to provide valuable insights into the potential of EOs as an alternative therapy in bovine mastitis, specifically targeting yeasts. Such findings could offer new strategies in the mycotic mastitis control and reducing the occurrence of secondary infections following antibiotic treatment.

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