Evaluation of neopterin levels in patients undergoing hemodialysis

Aşçı, Ali; Baydar, Terken; Çetinkaya, Ramazan; Dolgun, Anıl; Şahin, Gönül

doi:10.1111/j.1542-4758.2010.00439.x

Cited by 10 publications

(6 citation statements)

References 33 publications

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“…GTPCH I is activated with proinflammatory cytokines, which can also activate monocyte/ macrophages and lead to increased neopterin levels in parallel to biopterin. Increasing neopterin levels can be confirmed by previous studies on hemodialysis patients [22]. Okumura et al [23] found that renal BH 4 levels decreased in the type II diabetic rat model and that treatment with benidipine as an antihypertensive agent was effective in maintaining renal GTPCH I activity and BH 4 levels [23].…”

Section: Discussionmentioning

confidence: 67%

Evaluation of dihydropteridine reductase activities in patients with kidney failure

Palabıyık¹,

Aşçı²,

Girgin

et al. 2013

Pteridines

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End-stage renal disease (ESRD) is the inability of the kidneys to remove waste products from the blood. The most important factors causing ESRD that require hemodialysis are diabetes and hypertension. There are limited numbers of studies to evaluate tetrahydrobiopterin pathway in these patients. The aim of the study was to evaluate tetrahydrobiopterin pathway by measuring its important components, biopterin to creatinine concentrations and dihydropteridine reductase activities in diabetes and hypertension patients treated with/without hemodialysis. The patients undergoing hemodialysis were classified as diabetic nephropathy (n=21), hypertensive nephropathy (n=20) and others (n=30), while the controls consisted of healthy subjects (n=21), diabetic subjects (n=23) and hypertensive subjects (n=22) without any renal disorder. It was found that urinary biopterin to creatinine concentrations significantly increased in kidney failure patients undergoing hemodialysis compared to the healthy control group (p<0.05). Additionally, there were significant differences in urinary biopterin to creatinine concentrations between diabetes or hypertension patients and their hypertensive or diabetic control counterparts (both p<0.05). Our results indicated an alteration in tetrahydrobiopterin pathway in ESRD, and in the presence of secondary pathologies such as diabetes and hypertension in the patients undergoing hemodialysis, more considerable changes are observed in the pathway.

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Section: Discussionmentioning

confidence: 67%

Evaluation of dihydropteridine reductase activities in patients with kidney failure

Palabıyık¹,

Aşçı²,

Girgin

et al. 2013

Pteridines

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“…During dialysis, the immunulogiacal disturbances increase, so the relationship between HD vintage and serum neopterin seems to be quite obvious. However, the results obtained form other studies are inconclusive (see Godai et al, 1991, Asci et al, 2010.…”

Section: Discussionmentioning

confidence: 96%

“…The increased level of serum neopterin in ESRD can be explained by the impaired excretion as well as increased production of the compound due to systemic inflammatory processes. Our results have verified the knowledge received from other studies in which both serum and urinary neopterin levels were used as a diagnostic or as a prognostic marker in several pathologies including renal diseases (Berdowska, and Zwirska-Korczala, 2001, Lhee at al., 2006, Asci et al, 2010.…”

Section: Discussionmentioning

confidence: 99%

“…Regression coefficients and standard errors of the multiple linear regression with changes in the serum concentration of neopterin as dependent variables and urea, CA-IMT, peripheral systolic blood pressure, ferritin, hsCRP, HD vintage, BMI and eGFR as independent variables R = 97.9 %, R square = 95.89%, standard error of the estimate 65.868, P < 0.05. Asci et al, 2010). There is a growing interest towards the non-erythropoietic, tissue-protective and restorative actions of erythropoietin (EPO) (Ghezzi and Mengozzi, 2007).…”

Section: Discussionmentioning

confidence: 99%

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RESEARCH PAPER Neopterin in patients with chronic kidney disease and patients with coronary artery disease

Formanowicz¹

2012

bta

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Neopterin, a marker of stimulated cellular immune response, levels increase during many disorders. A number of different features of neopterin prompted us to study its serum concentration in patients with all stages of chronic kidney disease (CKD) and patients with coronary artery disease (CARD). To the best of our knowledge this is the first study that evaluates and compares the serum neopterin concentration in those diseases taken together as one study. One hundred and twenty five subjects, divided into five groups, were included in the study. The first three groups consisted of patients with different stages of CKD. CARD patients without CKD and healthy volunteers as controls were also studied. Serum neopterin concentration was measured by an enzyme-linked immunosorbent assay (ELISA, BRAHMS, Hennigsdorf/Berlin, Germany) according to the manufacturers' instructions. We have found that patients with the most advanced stage of CKD had fifteen times higher serum neopterin than patients from other studied groups. Interestingly, in the CKD1-2, CKD3-4 and CARD patients without CKD, serum neopterin concentrations were similar to those obtained from healthy volunteers. Serum urea and serum ferritin appeared to be significant independent predictors of serum neopterin concentration after adjustment for urea, CA-IMT, peripheral systolic blood pressure, ferritin, hsCRP, HD vintage, BMI and eGFR, explaining 95.89% of serum neopterin variations. In conclusion, it seems that despite the existence of many factors that may influence serum neopterin, those derived from impaired renal function and immunological disturbances coming from hemodialysis treatment are crucial. In this study, we observed that the more impaired the renal function, higher is the increase in serum neopterin concentration.

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“…Neopterin concentrations were determined by highperformance liquid chromatography (HPLC) using a fluorescence detector (HP, Agilent1100) at a wavelength of 353 nm for excitation and 438 nm for emission, as described before (21)(22)(23)(24). Creatinine concentrations were detected simultaneously by HPLC using an ultraviolet detector (HP, Agilent1100) at the wavelength of 235 nm.…”

Section: Methodsmentioning

confidence: 99%

Effects of Inhalation Anesthetics on the Profile of Urinary Neopterin as an Immune Marker in Patients who Underwent Laparoscopic Cholecystectomy

Capan

Baydar²,

Girgin³

et al. 2011

Pteridines

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It has been claimed that inhalational anesthetics affect many phases of immune response. Although, there are a lot of studies on the effects of widely used anaesthetic agents and methods on the immune system, there are only a few studies to show the effects by evaluation of neopterin concentrations as an important marker of cellular immunity. This study was done to evaluate possible effects of inhalation anesthetics, such as desflurane, isoflurane, and sevoflurane on the immune system by measuring urinary neopterin concentrations in patients who underwent laparoscopic cholecystectomy. The study is randomized, prospective and double blind. Urinary neopterin was measured in patients submitted to general anesthesia with either desflurane (n = 20) or isoflurane (n = 11), or sevoflurane (n = 13) in laparoscopic cholecystectomy. Urine samples were collected preoperatively, at 2nd and 24th hours post-operatively and the neopterin per creatinine concentrations were measured by using high-performance liquid chromatography.The preoperative neopterin levels were similar across the study groups. Variance analysis of repeated measures showed an effect of time (p <0.05): Neopterin concentrations increased over time, but the effect of different anesthetics on neopterin was similar. The mean increases in neopterin concentrations were similar among all the applied anesthetics. In conclusion, this report shows changes of immune response by investigation of neopterin in urine samples during 24 hours in patients exposed to three different inhalational anesthetic agents sevoflurane, desflurane and isoflurane in laparoscopic cholecystectomy.

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Evaluation of neopterin levels in patients undergoing hemodialysis

Cited by 10 publications

References 33 publications

Evaluation of dihydropteridine reductase activities in patients with kidney failure

Evaluation of dihydropteridine reductase activities in patients with kidney failure

RESEARCH PAPER Neopterin in patients with chronic kidney disease and patients with coronary artery disease

Effects of Inhalation Anesthetics on the Profile of Urinary Neopterin as an Immune Marker in Patients who Underwent Laparoscopic Cholecystectomy

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