Evaluation of nephroprotective and nephrocurative activity of Solanum nigrum on gentamicin induced nephrotoxicity in experimental rats

Kushwaha, Vimlesh; Sharma, Monica; Vishwakarma, Pinki; Saini, Manish Kumar; Bhatt, Shaily; Saxena, Kuldeep K.

doi:10.18203/2319-2003.ijbcp20160104

Cited by 2 publications

(2 citation statements)

References 13 publications

(14 reference statements)

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“…Fruit extract of S. nigrum (200 mg/kg) shows nephroprotective action by showing significant reductions in blood urea nitrogen and serum creatinine. Results were compared with gentamicin-induced nephrotoxic rats [ 182 ]. A similar study performed by the same researcher, along with histopathology, proves the efficacy of plant fruits as a nephroprotective agent [ 183 ].…”

Section: Potential Role Of Solanum Nigrum In Post-...mentioning

confidence: 99%

Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate

et al. 2023

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COVID-19 is caused by severe acute respiratory syndrome coronavirus-2, SARS-CoV-2. COVID-19 has changed the world scenario and caused mortality around the globe. Patients who recovered from COVID-19 have shown neurological, psychological, renal, cardiovascular, pulmonary, and hematological complications. In some patients, complications lasted more than 6 months. However, significantly less attention has been given to post-COVID complications. Currently available drugs are used to tackle the complications, but new interventions must address the problem. Phytochemicals from natural sources have been evaluated in recent times to cure or alleviate COVID-19 symptoms. An edible plant, Solanum nigrum, could be therapeutic in treating COVID-19 as the AYUSH ministry of India prescribes it during the pandemic. S. nigrum demonstrates anti-inflammatory, immunomodulatory, and antiviral action to treat the SARS-CoV-2 infection and its post-complications. Different parts of the plant represent a reduction in proinflammatory cytokines and prevent multi-organ failure by protecting various organs (liver, kidney, heart, neuro, and lung). The review proposes the possible role of the plant S. nigrum in managing the symptoms of COVID-19 and its post-COVID complications based on in silico docking and pharmacological studies. Further systematic and experimental studies are required to validate our hypothesis.

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Section: Potential Role Of Solanum Nigrum In Post-...mentioning

confidence: 99%

Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate

et al. 2023

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“…D. metel is commonly known as thorn's apple, Indian apple or devil's trumpet which is distributed all over the world such as Nigeria, Central Asia, Bangladesh and Central Ame-rica (12,13). Similarly, it has reported that traditionally D. metel was remedy for renal toxicity (14,15). IT has been reported that the crude methanolic extracts of D. metel has the ability to exhibit antioxidant activity due to free radical scavenging activity (16,17).…”

Section: Introductionmentioning

confidence: 97%

Nephroprotective effects of Datura metel extract in gentamicin induced mice model: biochemical and histological evidences

Alam

Khan

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Datura metel is traditionally used as a remedy for renal toxicity. However, the nephroprotection has not been scientifically validated yet. To evaluate the nephroprotective like effect of methanolic extract of D. metel in gentamicin induced mice model, mice of either sex were divided into groups. One group received normal saline as negative control. The 2 nd group received gentamicin 100mg/kg for 8 days as positive control, 3 rd group received 50mg/kg silymarin as standard, while the reaming groups received 100, 200 and 300 mg/kg of MEDM and gentamicin 100mg/kg, for 8 days. The blood and urine samples were collected on 9 th day, animals were then dissected and whole kidneys were removed and preserved in formalin for later histological examinations. The level of serum creatinine, blood urea nitrogen, urine creatinine and urine urea were significantly (P<0.05) elevated and the renal MDA level was also elevated significantly (P<0.05) by gentamicin in mice. After the treatment of test animals with MEDM, the elevated level of serum and urine biomarkers by gentamicin were reversed by MEDM.The nephroprotective effect was found in dose dependent manner. As the MEDM significantly protected the nephrotoxicity via its antioxidant effect. The findings of our study thus proved the scientific background for the nephroprotective effect of MEDM.

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Evaluation of nephroprotective and nephrocurative activity of Solanum nigrum on gentamicin induced nephrotoxicity in experimental rats

Cited by 2 publications

References 13 publications

Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate

Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate

Nephroprotective effects of Datura metel extract in gentamicin induced mice model: biochemical and histological evidences

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