Evaluation of neuroendocrine tumors with 99mTc-EDDA/HYNIC TOC

Artiko, Vera; Afgan, Aida; Petrović, Jelena; Radović, Branislava; Petrović, Nikola; Vlajković, Marina; Šobić-Šaranović, Dragana; Obradović, Vladimir

doi:10.5603/nmr.2016.0020

Cited by 34 publications

(25 citation statements)

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“…Bearing in mind that still the ideal radiopharmaceutical for scintigraphic diagnosis of NETs has not been discovered, there are a lot of them under investigation[ 30 - 32 ] such as: 99m Tc-EDDA--tricine-HYNIC-NATE, 99m Tc-EDDA/HYNIC-Tyrosine3-octreotate, 99m Tc-6-hydrazinopyridine-3-carboxylic acid (0)-octreotide or indium-111 (tetraxetan- tyrosine3-octreotate), 99m Tc-demotate or 99m Tc-P829. Wider application of hybrid systems (SPECT/CT, SPECT/MRI) as well as new cadmium-zinc-telluride SPECT and SPECT/CT cameras increased and widened application and increased the accuracy of somatostatin receptor scintigraphy[ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Saponjski

Macut

Šobić-Šaranović

et al. 2020

WJCC

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BACKGROUND Neuroendocrine tumors of appendix (ANETs) known as carcinoids, are rare endocrine neoplasms originated from enterochromaffin cells of gastrointestinal tract. ANETs are the third most frequent (16.7%) gastrointestinal neuroendocrine tumors, with the incidence of 0.08-0.2 cases/100000 during one year. Incidental ANETs occur in 0.2%-0.7% of emergency surgical resections because of suspected appendicitis which is usually the first manifestation of ANET. Although there are a lot of papers about application of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumors, there are very rare sporadic cases described about ANETs particularly. AIM To establish the role of somatostatin receptor scintigraphy (SRS) in the management of patients with neuroendocrine tumors of appendix (ANET). METHODS The total of 35 patients was investigated, 23 females and 12 males, average age (43.7 ± 17.3 years). All patients had histological diagnosis of ANET (34 carcinoids of appendix and one tubular carcinoid). Majority of tumors have been found incidentally during surgery of: Acute appendicitis ( n = 15), perforated appendicitis ( n = 2), ileus ( n = 3), hysterectomy ( n = 3), ruptured ovarian cyst ( n = 2), caecal volvulus ( n = 1), while 9 patients had diagnosis of appendiceal tumor before the surgery. Seventeen patients had tumor grade (G) G1, 12 G2 and 6 G3. The right hemicolectomy was performed in 13, while the rest of the patients had appendectomy only. SRS was done early (2 h) and late (24 h) after i.v . application of 740 MBq technetium-99m ethylenediamine-N, N'-diacetic acid Hydrazinonicotinyl-Tyr3-Octreotide (technetium-99m-Tektrotyd, Polatom, Poland). SRS was performed for restaging in all the patients after surgery. RESULTS There were 12 true positive (TP), 19 true negative, 3 false positive and 1 false negative SRS result. Sensitivity of the method was 92.31%, specificity was 86.36%, positive predictive value was 80.00%, negative predictive value was 95.00% and accuracy 88.57%. Receiver operating characteristics analysis showed that SRS scintigraphy is a good test for detection TP cases [area under the curve of 0.850, 95% confidence interval (CI): 0.710-0.990, P < 001]. Single photon emission computed tomography contributed diagnosis in 7 TP findings. In 10 patients Krenning score was 4 and in 2 was 3. In 8 patients SRS significantly changed the management of the patients (in two surgery was repeated, in 4 somatostatin analogues and in two peptide receptor radionuclide therapy). Median progression-free survival in SRS positive patients was 52 months (95%CI: 39.7-117.3 mo) while in SRS negative patients it was 60 months (95%CI: 42.8-77.1 mo), without statistically significant differe...

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Section: Discussionmentioning

confidence: 99%

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Saponjski

Macut

Šobić-Šaranović

et al. 2020

WJCC

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“…In different papers,[ 15 16 17 18 19 ] the accuracy of 99m Tc-TOC in GEP-NETs was documented, for example, Chrapko et al . [ 20 ] showed the usefulness of 99m Tc-TOC in 117 NET patients, especially in primary diagnosis and restaging after primary tumor surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Artiko et al . [ 19 ] published preliminary results from a multicenter trial that included 495 patients with different NETs. There were 334 true positive, 73 true negative, 6 false positive, and 82 false-negative results.…”

Section: Discussionmentioning

confidence: 99%

99mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumors

Liepe

Becker

2018

World J Nucl Med

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The aim of this study was to assess the potential of 99mTc-Hynic-TOC imaging in the primary diagnosis and follow-up of midgut neuroendocrine tumors (NETs). In comparison to 111In-octreotide, 99mTc-Hynic-TOC has a higher imaging quality and leads to a lower radiation absorption in patients. 99mTc-Hynic-TOC was used for assessing primary diagnosis (n = 14) and during follow-up (n = 17) in patients with NETs. The scintigraphic findings were compared with computed tomography scans and follow-up. In 31 patients, 34 somatostatin receptor scans using 99mTc-Hynic-TOC were performed. The primary diagnoses were midgut NET. The scintigraphy was true positive in 17 patients, true negative in 9, false negative in 4, and false positive in 1. From these data, a sensitivity of 81%, specificity of 90%, positive predictive value of 94%, and negative predictive value of 69% were calculated. In summary, 99mTc-TOC represents a useful radiotracer in imaging SSTR-expressing tumor lesions with slightly higher sensitivity, higher imaging quality, and lower radiation exposure for patients compared to 111In-octreotide. A 1-day double-acquisition protocol should be used to reduce false-positive findings of the gut.

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“…Findings at integrated SPECT/CT and/or prior contrast enhanced imaging, specifically the absence of a focal lesion on anatomical imaging, surpassed the ability of the 2-hour study in aiding interpretation. Uncinate process activity is a well-known physiological appearance in SRS, occurring as a result of physiological peptide uptake [18][19][20] Pooled sensitivity (93%) and specificity (96%) for Gallium-68 labelled SSR PET-CT exceeds SRS SPECT/CT detection rates for NETs [22]. For this reason, SSR PET-CT has been widely adopted into routine clinical practice in many countries.…”

Section: Image Interpretationmentioning

confidence: 99%

Feasibility of a streamlined imaging protocol in technetium-99m-Tektrotyd somatostatin receptor SPECT/CT

et al. 2018

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Evaluation of neuroendocrine tumors with 99mTc-EDDA/HYNIC TOC

Abstract: BACKGROUND: This paper is the short review of our preliminary results obtained with

Cited by 34 publications

References 18 publications

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

99mTc-Hynic-TOC imaging in the diagnostic of neuroendocrine tumors

Feasibility of a streamlined imaging protocol in technetium-99m-Tektrotyd somatostatin receptor SPECT/CT

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