Evaluation of Neuromuscular and Cardiovascular Effects of Two Doses of Rapacuronium (ORG 9487) versus Mivacurium and Succinylcholine 

Abstract

Rapacuronium, 1.5 and 2.5 mg/kg, produced neuromuscular blockade as rapidly as succinylcholine and significantly faster than mivacurium. Although succinylcholine continued to show the shortest duration, 1.5 mg/kg rapacuronium used a rapid onset and a relatively short duration and may be considered an alternative to succinylcholine.

Evaluation of Tracheal Intubating Conditions and Serum Potassium Levels With Different Doses of Succinylcholine : A Prospective Randomized Comparative Study

“…Although the average change in Heart rate& NIBP was same with each dose, he found a statistically significant dose time interaction (P<0.01) in lower dose group with respect to HR & NIBP (SBP). However Miguel et al 15 compared rapacuronium and succinylcholine and observed that there was no clinically significant increase in the heart rate in succinylcholine group like in our study.…”

“…(Approximately 82%) while using 1mg/kg of succinylcholine. 15 In our study, respectively. It can be explained on the basis of the fact that neuromuscular block develops more rapidly in the airway than in the thumb.…”

Succinilcolina: 50 anos de soberania

“…In the last 2 years, there has been an increasing number of rocuronium allergic reactions in France, outdoing the number of cases with succinylcholine, atracurium, mivacurium and vecuronium 16 . Rapacuronium, a short acting non-depolarizing neuromuscular blocker -not never launched in Brazil -has a short onset time, with 1.5 mg.kg -1 doses allowing or good excellent tracheal intubation conditions 17,18 . However, after some months of clinical use, a high incidence of severe complications has already been observed, such as bronchospasm of questionable origin [19][20][21] .…”

“…Nos últi-mos 2 anos, na França, o maior número de reações alérgicas tem sido observado com o rocurônio, ultrapassando o número de casos com a succinilcolina, atracúrio, mivacúrio e com o vecurônio 16 . O rapacurônio, um bloqueador neuromuscular adespolarizante que não chegou a ser lançado no Brasil, apresenta um início de ação muito rápido, e doses de 1,5 mg.kg -1propiciam excelentes ou boas condições de intubação traqueal 17,18 , com uma duração de ação considerada curta 18 . No entanto, após alguns meses de uso clínico, já se observou a alta incidência de complicações graves, como o broncoespasmo de origem não totalmente esclarecida [19][20][21] .…”

“…propiciam excelentes ou boas condições de intubação traqueal 17,18 , com uma duração de ação considerada curta 18 . No entanto, após alguns meses de uso clínico, já se observou a alta incidência de complicações graves, como o broncoespasmo de origem não totalmente esclarecida [19][20][21] .…”