Evaluation of Neuroprotective Activity of <i>Melissa officinalis</i> in MPTP Model of Parkinson's Disease in Mice

P, Rajesh Kumar Reddy; Saravanan, J.; T, Praveen

doi:10.5958/0974-360x.2019.00349.4

Cited by 5 publications

(2 citation statements)

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“…The plant contains a variety of bioactive compounds including flavonoids, volatile oils, and phenolic acids. Lemon balm has antioxidant, neuroprotective, anxiolytic, and spasmolytic effects (Virchea et al, 2021; Reddy et al, 2019).…”

Section: Herbal Sleep‐inducing Medicinesmentioning

confidence: 99%

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Therapeutic potential of hypnotic herbal medicines: A comprehensive review

Ghasemzadeh Rahbardar,

Hosseinzadeh

2024

Phytotherapy Research

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Insomnia affects millions of people worldwide, prompting considerable interest in herbal remedies for its treatment. This review aims to assess the therapeutic potential of such remedies for insomnia by analyzing current scientific evidence. The analysis identified several herbs, including Rosmarinus officinalis, Crocus sativus, Rosa damascena, Curcuma longa, Valeriana officinalis, Lactuca sativa, Portulaca oleracea, Citrus aurantium, Lippia citriodora, and Melissa officinalis, which show promise in improving overall sleep time, reducing sleep latency, and enhancing sleep quality. These plants act on the central nervous system, particularly the serotonergic and gamma‐aminobutyric acid (GABA)ergic systems, promoting sedation and relaxation. However, further research is necessary to fully understand their mechanisms of action, optimal dosages, and treatment protocols. Combining herbal medicines with conventional treatments may offer an effective natural alternative for those seeking medication. Nevertheless, individuals should consult their healthcare provider before using herbal remedies for insomnia. While this review provides evidence supporting their use, additional high‐quality studies are needed to firmly establish their clinical efficacy.

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Section: Herbal Sleep‐inducing Medicinesmentioning

confidence: 99%

“…Lemon balm has antioxidant, neuroprotective, anxiolytic, and spasmolytic effects (Virchea et al, 2021;Reddy et al, 2019).…”

Section: Melissa Officinalis (Lemon Balm)mentioning

confidence: 99%

Therapeutic potential of hypnotic herbal medicines: A comprehensive review

Ghasemzadeh Rahbardar,

Hosseinzadeh

2024

Phytotherapy Research

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Neuroprotective role of Allium cepa and Allium sativum on Hippocampus, striatum and Cerebral cortex in Wistar rats

Nayak

Kumar

Hegde

et al. 2021

RJPT

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Natural products are gaining much importance in light of the serious side effects posed by drugs of chemical origin. High intake of foods rich in antioxidants reduces the risk of neurodegenerative disorders. Traditionally, Allium sativum L.(garlic) and Allium cepa. L (onion) has received considerable attention for their therapeutic benefits around the globe. The present study assesses the free radical scavenging role of Allium sativum and Allium cepa in cerebral cortex, striatum, and hippocampus. Adult wistar rats of either sex were grouped as control group (Group I) treated with normal saline and the two experimental group were treated with the aqueous bulbous extracts of dehydrated Allium sativum (Group II) and Allium cepa (Group III) was considered as treated groups. Homogenates of hippocampus, striatum and cerebral cortex were analyzed for biochemical and neuronal analysis. LD50 value of these extracts in rats was found at a dose of 500 mg/kg BW. A Significant decline (P<0.05) in the MDA level was observed in the hippocampus, striatum and cerebral cortex in group II when compared to group III. Total antioxidant level, GSH, SOD level was significantly high (P<0.001) in the treated groups. Neuronal increase was significant in Group II (P < 0.01) when compared to Group III. Allium sativum and Allium cepa was found to have a challenging role in hampering oxidative stress in Hippocampus, striatum and cerebral cortex, the target regions in neurological disorders. However, ample number of studies are required to establish their mechanism of action as a progression to clinical approach.

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Generation of Neurodegenerative phenotype using Drosophila melanogaster through paraquat treatment and an amelioration by Tinospora cordifolia (giloy)

Singh

Twinkle

Himalian

2021

RJPT

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Neurodegenerative diseases are non-curable for the modern world and mainly affecting the aged population across the globe. These diseases cause serious issues with compromised motor function and along with dementia. In the present study, we have explored the benefits of Tinospora cordifolia (giloy) against chemical-induced neurodegeneration in wild type Drosophila melanogaster (Oregon R+) also known as fruit fly. We examined the biochemical properties of Tinospora cordifolia (giloy) through phenolic content and antioxidant capacity. The antioxidant activities of giloy were judged by in vitro methods like total phenolic content and DPPH free radical scavenging assay against ascorbic acid as standard. We treated D. melanogaster with paraquat (PQ, 1.0mM and 2.0mM) for 24 and 48 h and after the treatment, neurodegeneration was evaluated through classical methods like locomotor assay and memory assay in fruit flies. Furthermore, we have also checked the impact of paraquat on the total survival of the flies to evaluat lonevity and we evident a significant amelioration in neurodegeneration due to co-treatment of Tinospora cordifolia as compared to paraquat-treated flies. We found an improved toal survival of D. melanogaster in PQ along with Tinospora cordifolia treated groups and evident a significant difference in locomotor as well as in memory assays. Conclusively, we may suggest that Tinospora cordifolia is having good phenolic content and free radical scavenging properties thereby D. melanogaster treated along with giloy exhibited reduced neurodegeneration and showed significant amelioration.

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Evaluation of Neuroprotective Activity of Melissa officinalis in MPTP Model of Parkinson's Disease in Mice

Cited by 5 publications

References 0 publications

Therapeutic potential of hypnotic herbal medicines: A comprehensive review

Therapeutic potential of hypnotic herbal medicines: A comprehensive review

Neuroprotective role of Allium cepa and Allium sativum on Hippocampus, striatum and Cerebral cortex in Wistar rats

Generation of Neurodegenerative phenotype using Drosophila melanogaster through paraquat treatment and an amelioration by Tinospora cordifolia (giloy)

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