Evaluation of new adipocytokines and insulin resistance in adolescents with polycystic ovary syndrome

Çekmez, Ferhat; Çekmez, Yasemin; Pirgon, Özgür; Canpolat, Fuat Emre; Aydınöz, Seçil; İpçioğlu, Osman Metin; Karademır, Ferhan

doi:10.1684/ecn.2011.0279

Cited by 59 publications

(52 citation statements)

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“…In the present study, plasma visfatin levels negatively correlated with FPG, however, positively correlated with HOMA-IR in the PCOS non-IR and control-IR participants, respectively. Consistent with this, a positive correlation between plasma visfatin levels and HOMA-IR has been observed in previous studies (11,17,21,22). Visfatin was reported to bind to the insulin receptor via a tyrosine kinase and phosphorylate/activate the signaling pathway, performing insulin-like activities (9).…”

Section: Discussionsupporting

confidence: 91%

“…However, additional studies indicated that there was no difference in plasma visfatin levels between PCOS patients and control subjects, specifically between normal weight PCOS patients and control subjects (19,20). Furthermore, the association between plasma visfatin and IR in PCOS is controversial, with a positive correlation being demonstrated in a number of studies (11,17,21,22), but not in others (20,23). Obesity may have been the confounding factor that influenced those results.…”

Section: Introductionmentioning

confidence: 99%

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Plasma visfatin levels and mRNA expression of visfatin in peripheral blood mononuclear cells and peripheral blood monocyte-derived macrophages from normal weight females with polycystic ovary syndrome

Zhang

Zhou²,

Tang

et al. 2014

Experimental and Therapeutic Medicine

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Polycystic ovary syndrome (PCOS) is a common reproductive endocrinology disease, however, an explicit etiology is not known. Insulin resistance (IR) appears to be central to the pathogenesis of PCOS and inflammation may be significant in the pathogenesis of IR in PCOS. The aims of the present study were to investigate the plasma visfatin level and the gene expression of visfatin in peripheral blood mononuclear cells (PBMCs) and peripheral blood monocyte-derived macrophages (PBMMs) from PCOS patients, in addition to investigating the association between PCOS and IR. A total of 21 PCOS patients and 21 control subjects were enrolled in the study; the homeostasis model assessment of insulin resistance (HOMA-IR) was considered to be a stratified method for establishing the subgroups. Fasting blood samples were collected and the levels of sex hormones, insulin, glucose, blood lipids and visfatin were measured. In addition, visfatin gene expression levels in PBMCs and PBMMs were assessed using quantitative polymerase chain reaction. The plasma visfatin and gene expression levels of visfatin in PBMCs and PBMMs were not observed to increase in the normal weight PCOS and normal weight IR patients. Furthermore, plasma visfatin levels did not correlate with the normal weight PCOS patients or the normal weight IR patients per se. Further investigation into the role of visfatin in the pathogenesis of PCOS or IR should examine macrophages in the tissues, rather than macrophages in the peripheral blood.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Plasma visfatin levels and mRNA expression of visfatin in peripheral blood mononuclear cells and peripheral blood monocyte-derived macrophages from normal weight females with polycystic ovary syndrome

Zhang

Zhou²,

Tang

et al. 2014

Experimental and Therapeutic Medicine

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“…Apelin levels were higher in non-obese PCOS patients, suggesting a compensatory mechanism for metabolic consequences of insulin resistance. Different from Cekmez’s study [34], lower serum concentrations of apelin were found in PCOS subjects by Altinkaya et al [42] with positive correlation with BMI, insulin, HOMA-IR, triglyceride and free testosterone, speculating that apelin can be used as a marker for insulin sensitivity. Conversely, Sun et al [43] observed significantly enhanced apelin concentration in PCOS patients with positive association with BMI and HOMA-IR; treatment with drospirenone-ethinylestradiol plus metformin improved insulin resistance and apelin levels.…”

Section: New Markers: Structure Action and Role In Insulin Resistancecontrasting

confidence: 61%

“…Similar findings in non-obese PCOS subjects were observed by Gen et al [33], who reported also a strong association with total cholesterol, high-density lipoprotein and markers of hyperandrogenism. Later, in a study performed on obese PCOS adolescent girls, Cekmez et al [34] showed a significant enhancement of HOMA-IR and visfatin and apelin levels and significantly lower adiponectin levels, speculating that adipocytokines can be used as specific markers for insulin resistance. Nevertheless, a recent meta-analysis including 1341 patients indicated visfatin levels were significantly elevated in PCOS subjects, suggesting that visfatin could be a potential biomarker for PCOS, but there was no correlation with insulin resistance, BMI and hyperandrogenism [35].…”

Section: New Markers: Structure Action and Role In Insulin Resistancementioning

confidence: 99%

New markers of insulin resistance in polycystic ovary syndrome

Polak

Czyźyk

Simoncini

et al. 2016

J Endocrinol Invest

189

127

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Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder in women of reproductive age. The diagnostic criteria include two out of three features: hyperandrogenism, polycystic ovaries on ultrasound and menstrual irregularities (Rotterdam Criteria 2003). PCOS patients are more vulnerable to develop diabetes, cardiovascular diseases and metabolic syndrome. Insulin resistance (IR) is prevalent in women with PCOS independently of obesity and is critically involved in reproductive and metabolic complications of the syndrome. Several tests have been developed to measure IR, some very reliable but complex like the hyperinsulinemic euglycemic glucose clamp and others less precise but easier and less invasive like HOMA-IR. New markers are needed to reach a more reliable assessment of insulin resistance. To date, several surrogate markers have been proposed in the literature to facilitate and improve the determination of IR. Many new proteins are strongly involved with PCOS physiopathology and IR, such as some adipocytokines (adiponectin, visfatin, vaspin and apelin), copeptin, irisin, PAI-1 and zonulin. Many other proteins have been proposed as potential new markers of IR in PCOS, such as resistin, leptin, RBP4, kisspetin and ghrelin, but their role is still controversial. In this review, we provide a short characterization of these new markers, recently studied as indicators of metabolic state.

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“…Although associations have been shown between apelin-12 and atopic dermatitis [28] and insulin resistance in adolescents with polycystic ovary syndrome [29], studies are lacking about associations of this adipocyte-secreted factor in obese children, and there is no agreement to date on whether apelin levels correlate with childhood obesity. Therefore, the purpose of the present study was to investigate possible correlations between apelin-12 levels and obesity in children in China and identify associations between apelin-12 and obesity-related markers, including lipids, insulin sensitivity and insulin resistance index.…”

Section: Introductionmentioning

confidence: 99%

Associations between Serum Apelin-12 Levels and Obesity-Related Markers in Chinese Children

Chen

et al. 2014

PLoS ONE

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ObjectiveTo investigate possible correlations between apelin-12 levels and obesity in children in China and associations between apelin-12 and obesity-related markers, including lipids, insulin sensitivity and insulin resistance index (HOMA-IR).MethodsForty-eight obese and forty non-obese age- and gender-matched Chinese children were enrolled between June 2008 and June 2009. Mean age was 10.42±2.03 and 10.86±2.23 years in obesity and control groups, respectively. Main outcome measures were apelin-12, BMI, lipids, glucose and insulin. HOMA-IR was calculated for all subjects.ResultsAll obesity group subjects had significantly higher total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), insulin levels and HOMA-IR (all P<0.05). In separate analyses, obese girls had significantly higher LDL-C, insulin and HOMA-IR than controls, and obese boys had significantly higher TC, TG, insulin and HOMA-IR than controls (all P<0.05). Apelin-12 levels were significantly higher in obese girls compared to controls (P = 0.024), and correlated positively with TG in all obese subjects. Among obese girls, apelin-12 levels correlated positively with TG, insulin and HOMA-IR after adjusting for age and BMI. In all boys (obese and controls) apelin-12 was positively associated with fasting plasma glucose (FPG). No significant correlations were found in either group between apelin-12 levels and other characteristics after adjusting for age, sex, and BMI.ConclusionsApelin-12 levels are significantly higher in obese vs. non-obese girls in China and correlate significantly with obesity-related markers insulin, HOMA-IR, and TG. Increased apelin-12 levels may be involved in the pathological mechanism of childhood obesity.

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Evaluation of new adipocytokines and insulin resistance in adolescents with polycystic ovary syndrome

Cited by 59 publications

References 0 publications

Plasma visfatin levels and mRNA expression of visfatin in peripheral blood mononuclear cells and peripheral blood monocyte-derived macrophages from normal weight females with polycystic ovary syndrome

Plasma visfatin levels and mRNA expression of visfatin in peripheral blood mononuclear cells and peripheral blood monocyte-derived macrophages from normal weight females with polycystic ovary syndrome

New markers of insulin resistance in polycystic ovary syndrome

Associations between Serum Apelin-12 Levels and Obesity-Related Markers in Chinese Children

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