Evaluation of newer prognostic markers for adult soft tissue sarcomas.

Levine, Edward A.; Holzmayer, Tatyana A.; Bacus, S. S.; Mechetner, Eugene; Mera, Robertino M.; Bolliger, C. T.; Roninson, Igor B.; Gupta, Tejpal

doi:10.1200/jco.1997.15.10.3249

Cited by 75 publications

(29 citation statements)

References 52 publications

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“…8,[20][21][22] Levine et al reported that high-level Ki-67 expression was an independent prognostic indicator that correlated with a poor outcome in patients with sarcoma. 10 Similar conclusions were reached in other studies. [23][24][25][26][27][28][29][30] Musella et al demonstrated that cyclin D1 overexpression was an independent factor for survival in patients with sarcoma, 11 and their results were confirmed in other reports.…”

Section: Discussionsupporting

confidence: 86%

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Immunoglobulin G is present in a wide variety of soft tissue tumors and correlates well with proliferation markers and tumor grades

Chen

Huang²,

et al. 2010

Cancer

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BACKGROUND:The traditional view that immunoglobulin (Ig) is produced only by B lymphocytes has been challenged, because it has been demonstrated that Ig genes and proteins are expressed in epithelial cancer cells. However, whether Ig expression in nonlymphoid cells is limited to epithelial cells is unclear. Because sarcomas differ distinctly from carcinomas in their biologic and clinical features, the authors investigated the question of nonlymphoid IgG expression in soft tissue lesions. METHODS: Immunohistochemistry, in situ hybridization, and polymerase chain reaction (PCR) were used to demonstrate IgG expression in 80 soft tissue lesions. The correlation between Ig expression and proliferation markers (proliferating cell nuclear antigen [PCNA], Ki-67, and cyclin D1) in sarcomas was investigated by immunohistochemical and statistical analyses. RESULTS: Igj was identified in 97.4% of sarcomas and in 31.7% of benign lesions by immunohistochemistry. The difference was statistically significant (P < .01). Messenger RNA from the IgG1 heavy-chain constant region was also detected by in situ hybridization. Variable-diversity-joining recombination sequences of both heavy and light chains were obtained by PCR and sequencing. Moreover, the labeling index of PCNA, Ki-67, and cyclin D1 was much higher in sarcomas with high Igj expression than in sarcomas with low Igj expression (P < .01 for PCNA and cyclin D1; P < .001 for Ki-67). There were more grade 3 sarcomas with high Igj expression compared with grade 1 and 2 sarcomas (P < .05). CONCLUSIONS: IgG was identified in a wide variety of soft tissue tumors and correlated well with proliferation markers and tumor grades. IgG may be a useful marker for cell proliferation in sarcomas.

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Section: Discussionsupporting

confidence: 86%

“…Among these, p53 and proliferation markers, including PCNA, Ki-67 (MIB-1), and cyclin D1, have been investigated. [8][9][10][11] These 3 proliferation markers and p53 were chosen for use in the current study on the basis of their previous application in sarcomas and the underlying cell biology of these markers.…”

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confidence: 99%

Immunoglobulin G is present in a wide variety of soft tissue tumors and correlates well with proliferation markers and tumor grades

Chen

Huang²,

et al. 2010

Cancer

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“…We found PgP staining (>25%) in 40% of MFH and in 19% in mixed STS (with 6/18 MFH in the latter series having high Pgp expression) (Table 13), which is in line with reports from other authors who have reported Pgp expression in >50% of MFH and in varying frequencies in other STS entities [97,102,121]. We could not detect any prognostic importance of Pgp in the MFH series, whereas it was a strong prognostic factor for metastasis in the mixed STS series (Table 15).…”

Section: Pgpsupporting

confidence: 82%

“…In a meta-analysis of 27 studies including 631 patients with osteosarcoma, Pakos and Ioannidis [133] demonstrated that Pgp was not associated with histological response to chemotherapy, but was a strong prognostic factor for disease relapse and progression. In STS, Pgp expression has been suggested as a marker for poor sensitivity to chemotherapy and worse survival [81,102]. In rhabdomyosarcoma (RMS), Komdeur et al [95] showed that pediatric tumors differ from adult tumors in the expression of multidrug resistance associated proteins.…”

Section: Pgpmentioning

confidence: 99%

Prognostic factors in soft tissue sarcomaTissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence

Engellau¹

2004

Acta Orthopaedica Scandinavica

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“…The expression of MDR proteins in soft tissue sarcoma has been correlated with a worse survival rate (24) or with a higher histologic grade (25). Leiomyosarcomas have been shown to have a weaker response to chemotherapy compared with other histologic types of sarcoma (26).…”

Section: Discussionmentioning

confidence: 99%

Multidrug Resistance Proteins in Gastrointestinal Stromal Tumors: Site-Dependent Expression and Initial Response to Imatinib

Théou

Gil

Devocelle

et al. 2005

Clinical Cancer Research

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Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumors of the digestive tract and respond poorly to chemotherapy. A tyrosine kinase inhibitor treatment, imatinib mesylate, was recently shown to have antitumor effects in metastatic patients. However, this drug is a substrate for multidrug resistance (MDR) proteins. Therefore, we investigated the expression of ABCB1 (P-glycoprotein), ABCC1 (MRP1), and ABCG2 (BCRP) by Western blotting in 21GISTs and 3 leiomyosarcomas. All the GISTs were positive for either ABCB1 (86% of cases) or ABCC1 expression (62%), but negative for ABCG2. ABCB1was expressed in all gastric GISTs, but in only 67% of nongastric GISTs. By contrast, ABCC1expression was more common in nongastric tumors (78% versus 42%). The levels of these MDR proteins in gastric GISTs were higher for ABCB1 (P = 0.007) and lower for ABCC1 (P = 0.004) compared with nongastric GISTs. We found no correlation between MDR protein expression and the risk assessment. None of the six patients treated with imatinib was resistant, although all were positive for at least one MDR protein. These results confirm that gastric and nongastric GISTs have different biological characteristics and suggest that MDR proteins do not impair the initial response of the tumor to imatinib.

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Evaluation of newer prognostic markers for adult soft tissue sarcomas.

Cited by 75 publications

References 52 publications

Immunoglobulin G is present in a wide variety of soft tissue tumors and correlates well with proliferation markers and tumor grades

Immunoglobulin G is present in a wide variety of soft tissue tumors and correlates well with proliferation markers and tumor grades

Prognostic factors in soft tissue sarcomaTissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence

Multidrug Resistance Proteins in Gastrointestinal Stromal Tumors: Site-Dependent Expression and Initial Response to Imatinib

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