Evaluation of Nootropic Activity of Achyranthes Aspera Leaves Extract in Wistar Rats

Abstract

Objective:The objective of the study was to evaluate the nootropic activity of hydroalcoholic extract of Achyranthes aspera leaves using elevated plus maze and radial arm maze.Methods: Adult Wistar rats were allotted to three groups; Group 1 served as control, Groups 2 and 3 received 200 mg/kg and 400 mg/kg of AA extract, respectively, orally for 2 weeks after which the extent of improvement of memory was assessed.Results: AA showed nootropic activity in both elevated plus maze and radial arm maze. 200 mg/kg of AA extract showed better improvement in learning and memory compared to 400 mg/kg. Conclusions:These results indicate that AA leaves extract clearly exhibited the improvement in learning and memory.

A Comprehensive Study on Ethno-Pharmacological Exploration of Achyranthes aspera Linn.

“…Hydroethanolic leaf extract of Achyranthes aspera exhibited nootropic activity, evaluated using elevated plus maze and radial arm maze tests. Oral administration of extracts for 4 weeks clearly demonstrated the improvement in hippocampus-dependent spatial learning and memory (Bhargavan et al, 2018). Swiss albino mice treated with methanolic extract of root of Achyranthes aspera exhibited better cognitive activity on account of modulation in glutamatergic and cholinergic neurotransmission in brain (Gawande et al, 2015).…”