Evaluation of nootropic activity of Limonia acidissima against scopolamineinduced amnesia on rats

Mali, Kailas K.; Sutar, Guruprasad; Devade, Omkar A.; DIAS, REMETH

doi:10.4274/tjps.galenos.2018.30316

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Previously, actophotometer has been deployed in the evaluation of the locomotion-related CNS depressant potential of medicinal plant extracts [59,60]. Using this locomotory activity index our findings indicate aqueous ethanol extracts of Tapinanthus globiferus leaf and Mucuna pruriens seed (MPS) extracts even high oral doses do not exert any significant CNS depressant or stimulant impact in mice.…”

Section: Discussionmentioning

confidence: 86%

Evaluation of the Neurobehavioural Toxicity Potential of Aqueous Ethanol Extracts of Leaf/Seed of Datura metel, Mucuna pruriens, and Tapinanthus globiferus Growing on Azadirachta indica Host Tree in Mice

Umarudeen A. M.,

Khan F.,

Tahir Y.

et al. 2023

IJBcRR

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Aqueous ethanol extracts of Mucuna pruriens seed (AEMPS), Datura metel leaf (AEDML) and seed (AEDMS), and Tapinanthus globiferus (AETGL) Growing on Azadirachta indica host tree are being evaluated for their anxiolytic, antidepressant, anti-parkinsonian, and addictive activities in other studies. The aim of this study was to investigate the liability or otherwise of extracts of the selected medicinal plants for some benzodiazepines-related neurobehavioural toxicities in mice. Actophotometry was used for the evaluation of the locomotory activity related to central nervous system depressant (cns) effect, diazepam-induced sleep potentiation for hypnotic liability, rodent beam (rod)-walking assay for balance and motor co-ordination, and novel object recognition test (NORT) for cognitive deficit evaluation. The results indicate, compared to negative control (distilled water) treatment mean values of 4.69±0.95 % locomotory activity reduction, 430.71±16.80 sec. sleep onset and 168.43±10.56 min. duration, 5.00±0.00 balance/motor co-ordination performance, and 54.41±1.99 novel object recognition, treatments with high oral doses of AETGL and AEMPS (1500 mg/kg each) did not significantly negatively impact these behavioural indices but even enhanced novel object recognition. High oral doses of AEDML and AEDMS (750 mg/kg each), and tramadol (133 mg/kg) caused significant (p<0.05) 42.24±2.64, 27.73±2.17, and 36.74±4.44, mean % locomotory activity reductions, 196.86±10.12, 193.88±15.39, and 189.14±18.31 second mean sleep onsets and 319.71±18.85, 309.57±20.27, and 356.00±26.01 minute mean sleep durations, 1.67±0.42, 1.30±0.40, 1.833±0.48 mean balance/motor co-ordination performances, and 40.49±5.45, 31.33±5.23, 19.37±3.96 mean novel object recognitions, respectively. Diazepam (2 mg/kg) treatment caused 33.71±2.19 mean % locomotory activity reduction, 1.33±0.49 mean balance/motor co-ordination performance, and 29.91±2.81 mean novel object recognitions. Additionally, most mouse groups exposed to tramadol, AEDML, and AEDMS extracts displayed unusual (hallucination-like, predator-like) fearful trepidations when in proximity with the novel objects. These findings indicate AETGL and AEMPS extracts may be devoid of neurobehavioural toxicities but tramadol, diazepam, AEDML and AEDMS extracts may be liable to significant sedative, hypnotic, myo-relaxant, and anti-cognitive effects. These findings justify the traditional uses of Tapinanthus species and Mucuna pruriens extracts for the treatment of memory deficits and related neurological disorders. They also justify the morbid and fatal toxicity risks associated with the use of Datura metel extracts, tramadol, and the benzodiazepines.

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Section: Discussionmentioning

confidence: 86%

Evaluation of the Neurobehavioural Toxicity Potential of Aqueous Ethanol Extracts of Leaf/Seed of Datura metel, Mucuna pruriens, and Tapinanthus globiferus Growing on Azadirachta indica Host Tree in Mice

Umarudeen A. M.,

Khan F.,

Tahir Y.

et al. 2023

IJBcRR

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“…These rats were subjected to stress by forced swim prior to the maze experiment to increase their stress levels. This was done to determine the effect of stress on the learning and memory retention capacity on the rats [16]. The result shown below was obtained.…”

Section: Resultsmentioning

confidence: 99%

Nootropic Activity of Ethanolic Extract of Zingiber officinale and Centella asiatica on Stress Induced Rats

Odinaka,

Oliver Asogwa,

Sarella

et al. 2023

ijcsrr

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Nootropics, natural or synthetic substances that boost brain function and cognitive abilities, were investigated in this study. Specifically, the effects of Zingiber officinale and Centella asiatica extracts were compared to the standard nootropic piracetam. Both plant extracts demonstrated nootropic activity and contained phytochemicals like flavonoids, tannins, and saponins that protect the brain from oxidative damage. Sterols such as stigmasterol inhibiting acetyl CoA esterase activity were also present. Tests were conducted on rats given the extracts or piracetam daily for 7 to 21 days. High and low doses were used. Nootropic effects were measured using elevated plus maze and Morris water maze tests compared to controls. The results were promising: At higher doses, the extracts significantly reduced latency time to 21 ± 0.33 seconds compared to 33.33 ± 0.12 seconds for piracetam and 54 ± 0.08 seconds for controls. This suggests the plant extracts have considerable nootropic potential when administered at higher doses.

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“…Further, there was a significant improvement in the time spent in the novel arm. The total arm entries in the Y‐maze also help in the evaluation of locomotor activity, which is highly reduced in AD patients with disease progression 50 . Treatment with test compounds and DNP induced significant improvement in the total arm entries.…”

Section: Discussionmentioning

confidence: 99%

Effect of sulfonamide derivatives of phenylglycine on scopolamine‐induced amnesia in rats

Ganeshpurkar

Singh

Tripathi

et al. 2023

Ibrain

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Alzheimer's disease is a neurodegenerative disease responsible for dementia and other neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier in our laboratory as selective butyrylcholinesterase inhibitors, were tested against scopolamine-induced amnesia to evaluate their pharmacodynamic effect. The efficacy of the compounds was determined by behavioral experiments using the Y-maze and the Barnes maze and neurochemical testing. Both compounds reduced the effect of scopolamine treatment in the behavioral tasks at a dose of 20 mg/kg. The results of the neurochemical experiment indicated a reduction in cholinesterase activity in the prefrontal cortex and the hippocampus. The levels of antioxidant enzymes superoxide dismutase and catalase were restored compared to the scopolamine-treated groups. The docking study on rat butyrylcholinesterase (BChE) indicated tight binding, with free energies of −9.66 and −10.23 kcal/ mol for compounds 30 and 33, respectively. The two aromatic amide derivatives of 2-phenyl-2-(phenylsulfonamido) acetic acid produced stable complexes with rat BChE in the molecular dynamics investigation.

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Evaluation of nootropic activity of Limonia acidissima against scopolamineinduced amnesia on rats

Cited by 3 publications

References 20 publications

Evaluation of the Neurobehavioural Toxicity Potential of Aqueous Ethanol Extracts of Leaf/Seed of Datura metel, Mucuna pruriens, and Tapinanthus globiferus Growing on Azadirachta indica Host Tree in Mice

Evaluation of the Neurobehavioural Toxicity Potential of Aqueous Ethanol Extracts of Leaf/Seed of Datura metel, Mucuna pruriens, and Tapinanthus globiferus Growing on Azadirachta indica Host Tree in Mice

Nootropic Activity of Ethanolic Extract of Zingiber officinale and Centella asiatica on Stress Induced Rats

Effect of sulfonamide derivatives of phenylglycine on scopolamine‐induced amnesia in rats

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