Evaluation of novel nutraceuticals based on the combination of oat beta-glucans and a green coffee phenolic extract to combat obesity and its comorbidities. A randomized, dose–response, parallel trial

Abstract

Obesity and its associated comorbidities are a major public health concern worldwide. Reduced energy intake and increased physical activity interventions have limited success in the long term. Nutraceuticals might be...

Regular Consumption of Green Coffee Phenol, Oat β-Glucan and Green Coffee Phenol/Oat β-Glucan Supplements Does Not Change Body Composition in Subjects with Overweight and Obesity

“…Bearing in mind the aforementioned studies, the lack of effects could be in part due to the length of intervention (under 12 weeks as in [ 23 ]) or to the type of BG product used, although the amount and concentration of oat BG were carefully selected, attending to the results of a dose–response study carried out by our group. In this parallel, randomised, blind study [ 36 ], two doses (3 g/d or 5 g/d) of two types of oat BG (35% and 70% BG) were used together with a fixed amount of 600 mg of decaffeinated green coffee hydroxycinnamates. Considering that the study followed a non-experimental pre-test/post-test design, in which the control was each individual at baseline, an improvement in total body fat percentage, visceral fat percentage, and waist and hip circumferences was observed after six weeks with the four treatments without differences among the food supplements.…”

“…Considering that the study followed a non-experimental pre-test/post-test design, in which the control was each individual at baseline, an improvement in total body fat percentage, visceral fat percentage, and waist and hip circumferences was observed after six weeks with the four treatments without differences among the food supplements. Afterwards, when the rates of change were calculated as [(end value-baseline value)/baseline value] and Bonferroni correction paired t -test was carried out, only the change rate of total body fat% was significantly lower with 5 g/d of the 70% BG [ 36 ], and thus that was the BG dose and product selected for the present study.…”

“…Considering the richness of 70% in B-Can™, 3.57 g were added to the formulation to ensure that each sachet of the supplement provided 2.5 g BG. The physicochemical properties (swelling, water-holding capacity, and oil-holding capacity), viscosity, and the total content in SDF and IDF were measured in our facilities at ICTAN and are described in Redondo-Puente et al [ 35 ] and Mateos et al [ 36 ]. The decaffeinated green coffee extract employed in the preparation of the food supplements was provided by Quimifarma Laboratorios S.L.…”

“…The decaffeinated green coffee extract employed in the preparation of the food supplements was provided by Quimifarma Laboratorios S.L. (Toledo, Spain), and its phenolic concentration was determined in our group [ 36 ], so that, considering the richness of 45.8% of PP analysed in the commercial extract, 0.66 g of GCP was added to the formulation of each sachet to provide 300 mg of phenolic compounds. Decaffeinated green coffee was used in order to avoid problems in case of hypertension and because it allowed for using higher quantities of coffee without having to take into account caffeine sensitivity, so the new supplements could be consumed by the largest group of people possible.…”

“…Volunteers consumed 2 sachets of the corresponding supplement per day, so the daily dose ingested was 5 g/d of BG and 600 mg/d of phenolic compounds. The quantities were selected following the results of a previous dose–response study carried out by our group [ 36 ], in which the formulation used in the present study proved to be the most effective in counteracting obesity-related comorbidities.…”