Evaluation of novel soya-lecithin formulations for dermal use containing ketoprofen as a model drug

“…This could be attributed to the physicochemical characteristics of the organogel components. Both lecithin 30,74,75 and capryol 90 ® oil 76,77 were reported as skin penetration enhancer. In addition, perhaps the particle size was one of the parameters that influenced percutaneous permeation of Tr.…”

Section: In Vitro Release Studymentioning

confidence: 99%

Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies

Elnaggar

Talaat

Bahey-El-Din

et al. 2016

IJN

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“…The pore size of the membrane was 0.2 mm. Cellulose acetate membrane was soaked in receptor medium (pH=7.4) for 24 h prior to the experiment 14) . After fixing the membrane between the donor and receptor compartments 0.2 g of the ketoprofen formulations were applied evenly onto the membrane.…”

Section: In Vitromentioning

confidence: 99%

Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery

et al. 2010

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The aim of the present study is to formulate and investigate the potential of nanoemulsion formulation for topical delivery of ketoprofen. In this study, Palm Oil Esters (POEs) a newly introduced oil by Universiti Putra Malaysia researchers was chosen for the oil phase of the nanoemulsion, because the oil was reported to be a good vehicle for pharmaceutical use. Oil-in-water nanoemulsion was prepared by spontaneous emulsification method. The droplets size was studied by laser scattering spectroscopy (Nanophox) and Transmission Electron Microscopy (TEM). Franz diffusion cells were used, to determine the drug release and drug transferred through methyl acetate cellulose membrane (artificial membrane). The results of droplets size analysis shows the droplets are in the range of nanoemulsion which is below than 500 nm. The in vitro release profile shows a sufficient percentage of drugs released through the methyl acetate cellulose membrane. This initial study showed that the nanoemulsion formulated using POEs has great potential for topical delivery of ketoprofen.

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Evaluation of novel soya-lecithin formulations for dermal use containing ketoprofen as a model drug

Cited by 73 publications

References 20 publications

Extension of nasal anti-Staphylococcus aureus efficacy of lysostaphin by its incorporation into a chitosan-o/w cream

Extension of nasal anti-Staphylococcus aureus efficacy of lysostaphin by its incorporation into a chitosan-o/w cream

Novel lecithin-integrated liquid crystalline nanogels for enhanced cutaneous targeting of terconazole: development, in vitro and in vivo studies

Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery

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