Evaluation of nursing and health care-associated pneumonia patients with poor performance status

The changes and its significance of peripheral blood NK cells in patients with tuberculous meningitis

“…Our study showed that the negative rate of IGRA in TBM patients was as high as 41.25% (33/80), significantly higher than that of PTB, and there was a trend of positive correlation between negative IGRA and the severity of TBM, which is consistent with the results of previous studies (Di and Li, 2018;Kim et al, 2018). It has been found that IGRA-negative TB patients had higher mortality, suggesting that IGRA-negative results may be a risk factor for the development of TBM, which may be caused by the reduction of CD4 + T cells and CD8 + T cells (Ngai et al, 2007;Nguyen et al, 2018;Yamasue et al, 2020). Multiple meta-analyses have shown that advanced age, low peripheral blood lymphocyte count, and decreased NKT cells may be common risk factors for false-negative IGRA (Nguyen et al, 2018;Yamasue et al, 2020), suggesting that cellular immune function is impaired in TBM patients (Wu Xueqiong, 2022).…”

“…It has been found that IGRA-negative TB patients had higher mortality, suggesting that IGRA-negative results may be a risk factor for the development of TBM, which may be caused by the reduction of CD4 + T cells and CD8 + T cells (Ngai et al, 2007;Nguyen et al, 2018;Yamasue et al, 2020). Multiple meta-analyses have shown that advanced age, low peripheral blood lymphocyte count, and decreased NKT cells may be common risk factors for false-negative IGRA (Nguyen et al, 2018;Yamasue et al, 2020), suggesting that cellular immune function is impaired in TBM patients (Wu Xueqiong, 2022). In addition, the absolute number of NKT cells in IGRA (+) TBM patients was significantly higher than that in the IGRA (−) group, which may be due to the proliferation of NKT cells to recognize glucolipid antigens after Mtb infection.…”