Seafood products have recently become attractive as a vital source of healthy food, functional supplements and as potential sources of medication. Yet, several edible marine organisms were consumed by the local folk as seafood without knowing their nutritional quality, their benefits, and their safety. The present study aimed to investigate the nutritional properties and safety of marine bivalve wedge calm mollusk Donox faba from Saudi Arabia to elucidate its real benefits for human consumption which may be in the future used as food supplement and may be played an important role in some pharmaceutical industries. Additionally, to identify any potential hazards to the general public's health that could be connected to consumption of such seafood. The dry weight samples of edible muscle tissue and shell of D. faba used to evaluate protein, carbohydrates, lipids, amino acids, vitamins B (B1, B2, B6, and B12), minerals (S, Ca, P, Na, K, Cu, Fe and Co) and non-essential metals (Cd, Pb and Hg) through biochemical analysis. The present study demonstrates that the. D. faba is highly nutritious and is considered to be very good alternative food source to fish for human consumption and thereby we encourage its consumption and utilization as a cheap healthy protein source instead of red meat products. Moreover, the present study suggests that the shells of this wedge clam can be used as a bioindicator of marine pollution, so, a close monitoring Evaluation of… Salam and Albenasy.