Evaluation of nutritional status in children with amblyopia

Subaşı, Sevgi Sevi; Altıntaş, Özgül; Mercan, Selda; Çizmecioğlu, Filiz Mine; Toprak, Muge; Emre, Esra

doi:10.5935/0004-2749.20190022

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…The decreased vascular density suggests a diminished coverage of blood vessels within the retina, potentially compromising the delivery of oxygen and nutrients to retinal tissues. Subasi et al 27 found that amblyopic children suffered from a deficiency of phosphorus, selenium, molybdenum, iodine, chromium, boron, beryllium, folate, and vitamin B12. On top of such nutritional deficiency, decreased contrast sensitivity and impaired visual acuity may exacerbate the visual deficits observed in amblyopia.…”

Section: Discussionmentioning

confidence: 99%

Reduced Retinal Vascular Density and Skeleton Length in Amblyopia

Su,

Ma,

et al. 2024

Trans. Vis. Sci. Tech.

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This study aimed to investigate the possible relationship between retinal vascular abnormalities and amblyopia by analyzing vascular structures of fundus images. Methods:In this observational study, retinal fundus images were collected from 36 patients with unilateral amblyopia, 33 patients with bilateral amblyopia, and 36 healthy control volunteers. We developed a customized training algorithm based on U-Net to digitalize the vasculature in the fundus images to quantify vascular density (area and fractal dimension), skeleton length, and number of bifurcation points. For statistical comparisons, this study divided participants into two groups. The amblyopic eyes and the fellow eyes of patients with unilateral amblyopia formed the paired group, while bilateral amblyopic patients and healthy controls formed the independent group. Results:In the paired group, the vascular area (P = 0.007), vascular fractal dimension (P = 0.007), and vascular skeleton length (P = 0.002) of the amblyopic eyes were significantly smaller than those of the fellow eyes. In the independent group, significant decreases in the vascular fractal dimension (P = 0.006) and skeleton length (P = 0.048) were observed in bilateral amblyopia compared to control. The vascular area was also significantly correlated with best-corrected visual acuity in amblyopic eyes. Conclusions:This study demonstrated that retinal vascular density and skeleton length in amblyopic eyes were significantly smaller compared to control, indicating an association between the changes in retinal vascular features and the state of amblyopia.Translational Relevance: Our algorithm presents amblyopic retinal vascular changes that are more biologically interpretable for both clinicians and researchers.

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Section: Discussionmentioning

confidence: 99%

Reduced Retinal Vascular Density and Skeleton Length in Amblyopia

Su,

Ma,

et al. 2024

Trans. Vis. Sci. Tech.

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“…O nervo óptico e as vias ópticas estão intactos e completamente normais ao nascimento, mas há um erro no desenvolvimento ou estímulo sendo possível a reversão aplicando a terapêutica adequada. (SUBASI et al, 2019).…”

Section: Classificaçãounclassified

“…A partir dos anos de 1960, Hubel e Weisel estudaram a neurofisiologia da ambliopia, com concepções sobre a perda considerável de neurônios binoculares e alterações da atividade neuronal da dominância ocular do olho não infectado (NOGUEIRA; FERREIRA; PINTO, 2013;SUBASI et al, 2019).…”

Section: Protocolos Atuaisunclassified

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Protocolos Atuais No Manejo Da Ambliopia Em Crianças

Aguiar¹,

Rached²,

Sonoda³

2022

RECIMA21

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A ambliopia é uma desordem visual com maior incidência em crianças, as dificuldades de tratamento se apresentam em decorrência do avanço da idade e a crença de que a plasticidade visual tende a diminuir. Objetiva-se investigar condições de tratamento para crianças amblíopes, através da classificação da ambliopia, identificação dos protocolos existentes para pacientes pediátricos e avaliação de tratamentos atuais desenvolvidos. Como metodologia, foi desenvolvida uma meta-análise, com revisão de estudos do período de 2018-2022, escritos em português, inglês e espanhol que trataram sobre ambliopia, plasticidade neural e protocolo de tratamento. Vislumbrando o tratamento para a ambliopia, as pesquisas ainda são incipientes, pois foi possível contemplar uma amostra mínima de literaturas, em sua maioria de estudos utilizando sempre objetivos semelhantes. Diante dos achados, a terapia de oclusão, terapias de estimulação cerebral, aprendizagem receptiva ou ainda intervenções de diferentes terapêuticas foram observados como tratamento promissores para ambliopia, pois de maneira individual ou correlacionadas possibilitam fortalecimento e recuperação binocular e estereopsia, levando a redução da ambliopia e melhoria da acuidade visual. A existência da plasticidade cerebral leva a reconhecer que protocolos de tratamento para ambliopias pediátricas podem continuar a ser desenvolvida, pois diante da adesão novos protocolos mistos podem e devem ser uma diretriz para os profissionais da saúde visual com abordagens que considere as particularidades do diagnóstico e graus de severidade, para que haja as devidas intervenções.

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Association of amblyopia and body mass index in children and adolescents

Khurana,

Chawla,

Singh

et al. 2024

Himal J Ophthalmol

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Purpose: The purpose of this study is to explore any association between body mass index (BMI) and anthropometric parameters and amblyopia in children and adolescents. Materials and Methods: A total of 82 participants, aged 4–18 years, were included in this cross-sectional, observational study. The anthropometric parameters, which included height, weight, and BMI Z score, were assessed in a subset of amblyopic children and adolescents. We compared these parameters with the healthy age and gender-matched control group. Results: The results revealed that out of all 82 participants, the mean age of 55 amblyopes was 9.11 ± 4.06 years (range, 4–18 years), and that of controls was 8.44 ± 3.69 years (range, 4–17 years). The mean ± standard deviation (SD) of height (cm) and weight (kg) in amblyopia was 129.69 ± 19.01 cm and 29.27 ± 12.01 kg, respectively, and in controls, it was 124.43 ± 13.83 cm (P = 0.159) and 27.01 ± 9.89 kg (P = 0.399). The median (25th–75th percentile) of the BMI Z score in the amblyopia group was -0.27 (-1.365 to 0.885), and in controls was 0.00.01 (-0.85885; P = 0.399). We did not find any clinically or statistically significant difference in the above parameters between cases and controls. Conclusion: This study concludes that amblyopes do not have deranged BMI and anthropometric parameters in the early years of life. Ophthalmologists are the primary healthcare professionals who have a crucial role in prompt identification and intervention to prevent long-term vision impairments in patients with amblyopia. Enhancements in visual acuity are expected to improve their overall quality of life and social well-being, which may reduce the other negative consequences in the form of deranged BMI and other related morbidities in their adulthood.

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Evaluation of nutritional status in children with amblyopia

Cited by 3 publications

References 17 publications

Reduced Retinal Vascular Density and Skeleton Length in Amblyopia

Reduced Retinal Vascular Density and Skeleton Length in Amblyopia

Protocolos Atuais No Manejo Da Ambliopia Em Crianças

Association of amblyopia and body mass index in children and adolescents

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