Evaluation of ocular arterial changes in glaucoma with color Doppler ultrasonography.

Abstract

The purpose of this study was to evaluate hemodynamic changes of the retrobulbar vasculature caused by different intraocular pressures with color Doppler ultrasonography. Fifty normal eyes in 25 patients, 13 patients with normal tension glaucoma, and 19 patients with acute glaucoma and increased intraocular pressure (greater than 30 mm Hg) were enrolled in this study. In 15 of 19 patients with acute glaucoma patients, follow-up color Doppler ultrasonography was also undertaken after laser peripheral iridectomy when the intraocular pressure had returned to normal. The peak systolic velocity, end diastolic velocity, resistive index, time average maximum velocity, and pulsatility index were compared in different vessels, including the central retinal artery, lateral posterior ciliary artery, medial posterior ciliary artery, and ophthalmic artery in each orbit. The peak systolic velocity, end diastolic velocity, and time average maximum velocity of the central retinal artery were significantly lower (P<0.01) in acute glaucoma patients than in the control group. The resistive index and pulsatility index of the central retinal artery were significantly higher (P<0.01) in acute glaucoma patients than in the control group. The end diastolic velocity of the lateral and medial posterior ciliary arteries was significantly lower in patients with acute glaucoma than in the control group, and the resistive index and pulsatility index of both of these arteries were significantly higher (P<0.001) in patients with acute glaucoma than in the control group. However, no statistical significantly differences were found in the peak systolic velocity or time average maximum velocity in either of the posterior ciliary arteries; similarly, no statistically significant differences were noted in any of the parameters in the ophthalmic artery between the control group and the group with acute glaucoma. The pulsatility index of the central retinal artery and of the lateral and medial posterior ciliary arteries was significantly lower (P<0.01) in acute glaucoma patients after laser therapy than in acute glaucoma patients before laser therapy. The resistive index of both posterior ciliary arteries was also significantly lower (P<0.004) in acute glaucoma patients after laser therapy than before laser therapy. All parameters for all vessels examined among the normal subjects, the patients with normal tension glaucoma, and the patients with acute glaucoma after laser therapy when the intraocular pressure had returned to normal showed no statistically significant differences. Color Doppler ultrasonography is a good modality for both imaging and studying the hemodynamics of the perioptic nerve vessels.

Differences in Ocular Blood Flow Between People of African and European Descent With Healthy Eyes

“…These differences were observed in the absence of differences in IOP, diabetes, systemic blood pressure and heart disease between the groups. Our results are consistent with previous studies in which reduced ocular blood flow velocities in the retrobulbar blood vessels have been reported in patients with POAG compared to controls; this finding has been reported in cohorts of ED [40][41][42] and of AD. 43 In addition, Siesky et al 31 reported lower blood flow values in all retrobulbar blood vessels in POAG patients of AD compared to those of ED.…”

The Effects of Menopause and Hormone Replacement Therapy on Quality and Quantity of Tear, Intraocular Pressure and Ocular Blood Flow

“…The blood velocities in the retrobulbar arteries vary with the individual’s age, systemic blood pressure, smoking habit and IOP [72, 73, 74]. It has been demonstrated that a significant increase in the RI and pulsatility index of the CRA, medial and lateral short posterior ciliary artery in patients with acute glaucoma returned to normal after therapy to normalize the IOP.…”

“…It has been demonstrated that a significant increase in the RI and pulsatility index of the CRA, medial and lateral short posterior ciliary artery in patients with acute glaucoma returned to normal after therapy to normalize the IOP. It has been suggested that acute elevations of IOP might decrease the blood supply to the optic disc [74]. A decrease in the RI, which generally reflects vascular bed resistance, was observed after surgically reducing IOP in patients with chronic glaucoma.…”

Disturbed correlation between arterial resistance and pulsatility in glaucoma patients

“…Its clinical use in ophthalmology, however, has not been as widespread as the Pourcelot index or resistive index (RI), with few studies determining its significance in glaucoma. Two studies Disturbed correlation between arterial resistance and pulsatility in glaucoma patients failed to identify differences in PI between healthy individuals and primary open-angle glaucoma (POAG) (Januleviciene et al 2008) or normal tension glaucoma (NTG) (Chiou et al 1999). In both cases, no further analysis was made to test how PI could relate to other variables.…”