Background/Objectives: To explore the weekend effect in four major cardiovascular emergenciesDesign: A retrospective cohort studySetting: Taiwan National Health Insurance (NHI) claims database, 2005~2015Participants: We extracted 3,811 incident cases of ruptured aortic aneurysm, 184,769 incident cases of acute myocardial infarction, 492,127 incident cases of ischemic stroke, and 15,033 incident cases of pulmonary embolism from 9,529,049 patients having at least one record of hospitalization in the NHI database within 2006~2014.Exposures: Admission on weekends or weekdaysMain outcomes and measures: In-hospital mortality and one-year mortality obtained from the Taiwan National Death RegistryResults: We found no difference in in-hospital mortality between weekend group and weekday group in patients with ruptured aortic aneurysm (45.4% vs 45.3%, adjusted odds ratio [OR] 1.01, 95% confidence interval [CI] 0.87-1.17, p=0.93), patients with acute myocardial infarction (15.8% vs 16.2%, adjusted OR 0.98, 95% CI 0.95-1.00, p=0.10), patients with ischemic stroke (4.1% vs 4.2%, adjusted OR 0.99, 95% CI 0.96-1.03, p=0.71), and patients with pulmonary embolism (14.6% vs 14.6%, adjusted OR 1.02, 95% CI 0.92-1.15, p=0.66). The results persisted for one year in all the four major cardiovascular emergencies. Conclusions: We found no difference in either short-term or long-term mortality between patients admitted on weekends and patients admitted on weekdays in four major cardiovascular emergencies.